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    Nt5m 5',3'-nucleotidase, mitochondrial [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287368, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Nt5mprovided by RGD
    Official Full Name
    5',3'-nucleotidase, mitochondrialprovided by RGD
    Primary source
    RGD:1309622
    See related
    Ensembl:ENSRNOG00000003332 AllianceGenome:RGD:1309622
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 5'-nucleotidase activity. Predicted to be involved in pyrimidine deoxyribonucleotide catabolic process. Predicted to act upstream of or within dUMP catabolic process. Orthologous to human NT5M (5',3'-nucleotidase, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 27.1), Brain (RPKM 27.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nt5m in Genome Data Viewer
    Location:
    10q22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (45151902..45178687)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (44652845..44680549)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (46216494..46244478)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene dCTP pyrophosphatase 1, pseudogene 1 Neighboring gene U1 spliceosomal RNA Neighboring gene COP9 signalosome subunit 3 Neighboring gene mediator complex subunit 9 Neighboring gene ras related dexamethasone induced 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of a human mitochondrial deoxyribonucleotidase. Rinaldo-Matthis A, et al. Nat Struct Biol, 2002 Oct. PMID 12352955
    2. Human mitochondrial 5'-deoxyribonucleotidase. Overproduction in cultured cells and functional aspects. Gallinaro L, et al. J Biol Chem, 2002 Sep 20. PMID 12124385
    3. A deoxyribonucleotidase in mitochondria: involvement in regulation of dNTP pools and possible link to genetic disease. Rampazzo C, et al. Proc Natl Acad Sci U S A, 2000 Jul 18. PMID 10899995, Free PMC Article
    4. Mouse cytosolic and mitochondrial deoxyribonucleotidases: cDNA cloning of the mitochondrial enzyme, gene structures, chromosomal mapping and comparison with the human orthologs. Rampazzo C, et al. Gene, 2002 Jul 10. PMID 12234672
    5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 5'-nucleotidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-nucleotidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within dUMP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pyrimidine deoxyribonucleotide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    5'(3')-deoxyribonucleotidase, mitochondrial
    NP_001386507.1
    XP_038941328.1
    XP_038941329.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399578.1 → NP_001386507.1  5'(3')-deoxyribonucleotidase, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      B2RZ81, D4A5J2
      Related
      ENSRNOP00000004448.5, ENSRNOT00000004448.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      45151902..45178687
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085401.2 → XP_038941329.1  5'(3')-deoxyribonucleotidase, mitochondrial isoform X2

      Conserved Domains (1) summary
      cl21460
      Location:28 → 136
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    2. XM_039085400.2 → XP_038941328.1  5'(3')-deoxyribonucleotidase, mitochondrial isoform X1

      Conserved Domains (1) summary
      cl21460
      Location:37 → 125
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    RNA

    1. XR_005489727.2 RNA Sequence

    2. XR_010055145.1 RNA Sequence

    3. XR_005489725.2 RNA Sequence

    4. XR_010055146.1 RNA Sequence

    5. XR_005489729.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001105785.1: Suppressed sequence

      Description
      NM_001105785.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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