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    Tcerg1 transcription elongation regulator 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307474, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Tcerg1provided by RGD
    Official Full Name
    transcription elongation regulator 1provided by RGD
    Primary source
    RGD:1311748
    See related
    Ensembl:ENSRNOG00000018849 AllianceGenome:RGD:1311748
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ca150
    Summary
    Predicted to enable several functions, including enzyme binding activity; identical protein binding activity; and proline-rich region binding activity. Predicted to be involved in RNA processing and regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human TCERG1 (transcription elongation regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 224.0), Spleen (RPKM 208.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tcerg1 in Genome Data Viewer
    Location:
    18p11
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (34756558..34817441)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (34505708..34566470)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (36796290..36889966)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene POU class 4 homeobox 3 Neighboring gene G protein-coupled receptor 151 Neighboring gene ubiquitin-40S ribosomal protein S27a pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CA150 expression delays striatal cell death in overexpression and knock-in conditions for mutant huntingtin neurotoxicity. Arango M, et al. J Neurosci, 2006 Apr 26. PMID 16641246, Free PMC Article
    2. General structural motifs of amyloid protofilaments. Ferguson N, et al. Proc Natl Acad Sci U S A, 2006 Oct 31. PMID 17060612, Free PMC Article
    3. Structural characterization of a new binding motif and a novel binding mode in group 2 WW domains. Ramirez-Espain X, et al. J Mol Biol, 2007 Nov 9. PMID 17915251
    4. Transcription elongation regulator 1 is a co-integrator of the cell fate determination factor Dachshund homolog 1. Zhou J, et al. J Biol Chem, 2010 Dec 17. PMID 20956529, Free PMC Article
    5. Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics. Yang W, et al. J Proteome Res, 2012 Feb 3. PMID 22082260, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables proline-rich region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-like protein conjugating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transcription elongation regulator 1
    Names
    coactivator of 150 kD

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107390.2 → NP_001100860.2  transcription elongation regulator 1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A8I6GKL3, D3ZTL0
      Related
      ENSRNOP00000025467.5, ENSRNOT00000025467.7
      Conserved Domains (4) summary
      smart00441
      Location:938 → 993
      FF; Contains two conserved F residues
      smart00456
      Location:132 → 164
      WW; Domain with 2 conserved Trp (W) residues
      cd00201
      Location:416 → 445
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam01846
      Location:777 → 826
      FF; FF domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      34756558..34817441
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254673.5 → XP_006254735.1  transcription elongation regulator 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GKL3
      Conserved Domains (5) summary
      smart00441
      Location:955 → 1010
      FF; Contains two conserved F residues
      cl14654
      Location:827 → 905
      V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
      smart00456
      Location:132 → 164
      WW; Domain with 2 conserved Trp (W) residues
      cd00201
      Location:416 → 445
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam01846
      Location:794 → 843
      FF; FF domain

    2. XM_039096854.2 → XP_038952782.1  transcription elongation regulator 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6GKL3
      Conserved Domains (4) summary
      COG5104
      Location:404 → 934
      PRP40; Splicing factor [RNA processing and modification]
      pfam05109
      Location:239 → 327
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00397
      Location:137 → 162
      WW; WW domain
      pfam01846
      Location:960 → 1019
      FF; FF domain

    3. XM_063277363.1 → XP_063133433.1  transcription elongation regulator 1 isoform X6

      UniProtKB/TrEMBL
      A6J3K5

    4. XM_006254674.5 → XP_006254736.1  transcription elongation regulator 1 isoform X2

      See identical proteins and their annotated locations for XP_006254736.1

      UniProtKB/TrEMBL
      A0A8I6GKL3, B5DEZ4
      Related
      ENSRNOP00000073243.1
      Conserved Domains (4) summary
      smart00441
      Location:934 → 989
      FF; Contains two conserved F residues
      smart00456
      Location:132 → 164
      WW; Domain with 2 conserved Trp (W) residues
      cd00201
      Location:395 → 424
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam01846
      Location:773 → 822
      FF; FF domain

    5. XM_006254675.5 → XP_006254737.1  transcription elongation regulator 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AM46, A0A8I6GKL3
      Related
      ENSRNOP00000094971.1
      Conserved Domains (4) summary
      smart00441
      Location:917 → 972
      FF; Contains two conserved F residues
      smart00456
      Location:132 → 164
      WW; Domain with 2 conserved Trp (W) residues
      cd00201
      Location:395 → 424
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      pfam01846
      Location:756 → 805
      FF; FF domain

    6. XM_017600960.3 → XP_017456449.2  transcription elongation regulator 1 isoform X5

      Conserved Domains (4) summary
      smart00441
      Location:698 → 753
      FF; Contains two conserved F residues
      PHA03247
      Location:21 → 161
      PHA03247; large tegument protein UL36; Provisional
      COG5104
      Location:147 → 625
      PRP40; Splicing factor [RNA processing and modification]
      pfam01846
      Location:641 → 692
      FF; FF domain

    7. XM_039096855.2 → XP_038952783.1  transcription elongation regulator 1 isoform X7

      Conserved Domains (3) summary
      smart00441
      Location:486 → 541
      FF; Contains two conserved F residues
      COG5104
      Location:48 → 413
      PRP40; Splicing factor [RNA processing and modification]
      pfam01846
      Location:429 → 480
      FF; FF domain

    RNA

    1. XR_361332.5 RNA Sequence

    2. XR_005496033.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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