ZNF609 zinc finger protein 609 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZNF609provided by HGNC
Official Full Name: zinc finger protein 609provided by HGNC
Primary source: HGNC:HGNC:29003
See related: Ensembl:ENSG00000180357 MIM:617474; AllianceGenome:HGNC:29003
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Predicted to enable promoter-specific chromatin binding activity. Involved in regulation of myoblast proliferation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis (RPKM 16.5), ovary (RPKM 10.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q22.31

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (64459578..64686068)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (62269004..62495294)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (64752777..64978267)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A protein encoded by circular ZNF609 RNA induces acute kidney injury by activating the AKT/mTOR-autophagy pathway.
Title: A protein encoded by circular ZNF609 RNA induces acute kidney injury by activating the AKT/mTOR-autophagy pathway.
YY1 and eIF4A3 are mediators of the cell proliferation, migration and invasion in cholangiocarcinoma promoted by circ-ZNF609 by targeting miR-432-5p to regulate LRRC1.
Title: YY1 and eIF4A3 are mediators of the cell proliferation, migration and invasion in cholangiocarcinoma promoted by circ-ZNF609 by targeting miR-432-5p to regulate LRRC1.
Circular RNA ZNF609 drives tumor progression by regulating the miR-138-5p/SIRT7 axis in melanoma.
Title: Circular RNA ZNF609 drives tumor progression by regulating the miR-138-5p/SIRT7 axis in melanoma.
CircRNA ZNF609 promotes angiogenesis in nasopharyngeal carcinoma by regulating miR-145/STMN1 axis.
Title: CircRNA ZNF609 promotes angiogenesis in nasopharyngeal carcinoma by regulating miR-145/STMN1 axis.
Circ-ZNF609 promotes carcinogenesis of gastric cancer cells by inhibiting miRNA-145-5p expression.
Title: Circ-ZNF609 promotes carcinogenesis of gastric cancer cells by inhibiting miRNA-145-5p expression.
CircRNA ZNF609 promotes growth and metastasis of nasopharyngeal carcinoma by competing with microRNA-150-5p.
Title: CircRNA ZNF609 promotes growth and metastasis of nasopharyngeal carcinoma by competing with microRNA-150-5p.
our current study reveals the role of the circ-ZNF609/miR-138-5p/FOXP4 regulatory network in renal carcinoma and provides a new perspective for the pathogenesis of renal carcinoma.
Title: CircRNA ZNF609 functions as a competitive endogenous RNA to regulate FOXP4 expression by sponging miR-138-5p in renal carcinoma.
Circular RNA circ-ZNF609 is associated with heavy polysomes, and it is translated into a protein in a splicing-dependent and cap-independent manner, resulting in a protein that controls myoblast proliferation.
Title: Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis.
these findings illustrated that cir-ZNF609 took part in the onset of HSCR through the crosstalk with AKT3 by competing for shared miR-150-5p.
Title: Circular RNA ZNF609 functions as a competitive endogenous RNA to regulate AKT3 expression by sponging miR-150-5p in Hirschsprung's disease.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-36468 (e-PCR)
- UniSTS:17155

SHGC-132603 (e-PCR)
- UniSTS:185365

A006R24 (e-PCR)
- UniSTS:12158

D1S3695 (e-PCR)
- UniSTS:474273

RH66579 (e-PCR)
- UniSTS:88739

RH44856 (e-PCR)
- UniSTS:37083

FB5E9 (e-PCR)
- UniSTS:38370

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables promoter-specific chromatin binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in muscle organ development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of myoblast proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zinc finger protein 609

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_015042.2 → NP_055857.1 zinc finger protein 609

See identical proteins and their annotated locations for NP_055857.1

Status: VALIDATED

Source sequence(s)

AC090543, AC091231

Consensus CDS

CCDS32270.1

UniProtKB/Swiss-Prot

O15014, Q0D2I2

Related

ENSP00000316527.3, ENST00000326648.5

Conserved Domains (2) summary

PTZ00121
Location:1002 → 1200

PTZ00121; MAEBL; Provisional

COG5189
Location:412 → 533

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000015.10 Reference GRCh38.p14 Primary Assembly

Range

64459578..64686068

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047432263.1 → XP_047288219.1 zinc finger protein 609 isoform X1

UniProtKB/Swiss-Prot

O15014, Q0D2I2
XM_047432265.1 → XP_047288221.1 zinc finger protein 609 isoform X1

UniProtKB/Swiss-Prot

O15014, Q0D2I2
XM_017022021.2 → XP_016877510.1 zinc finger protein 609 isoform X1

UniProtKB/Swiss-Prot

O15014, Q0D2I2

Conserved Domains (2) summary

PTZ00121
Location:1002 → 1200

PTZ00121; MAEBL; Provisional

COG5189
Location:412 → 533

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
XM_047432266.1 → XP_047288222.1 zinc finger protein 609 isoform X1

UniProtKB/Swiss-Prot

O15014, Q0D2I2

Alternate T2T-CHM13v2.0

Genomic

NC_060939.1 Alternate T2T-CHM13v2.0

Range

62269004..62495294

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054377549.1 → XP_054233524.1 zinc finger protein 609 isoform X1

UniProtKB/Swiss-Prot

O15014, Q0D2I2
XM_054377550.1 → XP_054233525.1 zinc finger protein 609 isoform X1

UniProtKB/Swiss-Prot

O15014, Q0D2I2
XM_054377548.1 → XP_054233523.1 zinc finger protein 609 isoform X1

UniProtKB/Swiss-Prot

O15014, Q0D2I2
XM_054377551.1 → XP_054233526.1 zinc finger protein 609 isoform X1

UniProtKB/Swiss-Prot

O15014, Q0D2I2