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    SUPT7L SPT7 like, STAGA complex subunit gamma [ Homo sapiens (human) ]

    Gene ID: 9913, updated on 5-Mar-2024

    Summary

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    Official Symbol
    SUPT7Lprovided by HGNC
    Official Full Name
    SPT7 like, STAGA complex subunit gammaprovided by HGNC
    Primary source
    HGNC:HGNC:30632
    See related
    Ensembl:ENSG00000119760 MIM:612762; AllianceGenome:HGNC:30632
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPT7L; STAF65; SUPT7H; STAF65G; STAF65(gamma)
    Summary
    SUPT7L is a protein subunit of the human STAGA complex (SPT3; (MIM 602947)/TAF9 (MIM 600822)/GCN5 (MIM 602301) acetyltransferase complex), which is a chromatin-modifying multiprotein complex (Martinez et al., 2001 [PubMed 11564863]).[supplied by OMIM, Apr 2009]
    Expression
    Ubiquitous expression in brain (RPKM 10.8), spleen (RPKM 8.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    2p23.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (27642568..27663614, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (27685653..27706702, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27873676..27886481, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 1109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15509 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15510 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15511 Neighboring gene coiled-coil domain containing 121 Neighboring gene GPN-loop GTPase 1 Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:27875474-27876673 Neighboring gene solute carrier family 4 member 1 adaptor protein Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:27904532-27905731 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11303 Neighboring gene long intergenic non-protein coding RNA 1460 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11304

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The transcriptional repression activity of STAF65γ is facilitated by promoter tethering and nuclear import of class IIa histone deacetylases. Hsieh FS, et al. Biochim Biophys Acta, 2014 Jul. PMID 24852358
    2. A new tumor-rejection antigen recognized by cytotoxic T lymphocytes infiltrating into a lung adenocarcinoma. Nishizaka S, et al. Cancer Res, 2000 Sep 1. PMID 10987294
    3. Recognition of a new ARTC1 peptide ligand uniquely expressed in tumor cells by antigen-specific CD4+ regulatory T cells. Wang HY, et al. J Immunol, 2005 Mar 1. PMID 15728473
    4. Transcriptional and subcellular regulation of the TRIP-Br family. Lai IL, et al. Gene, 2007 Feb 15. PMID 17141982
    5. Multivalent binding of p53 to the STAGA complex mediates coactivator recruitment after UV damage. Gamper AM, et al. Mol Cell Biol, 2008 Apr. PMID 18250150, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our findings reveal a distinct role of STAF65gamma in nuclear import, transcriptional repression, and cell cycle regulation at high levels of expression, which is associated with poor clinical outcomes of lung adenocarcinoma.
      Title: The transcriptional repression activity of STAF65γ is facilitated by promoter tethering and nuclear import of class IIa histone deacetylases.
    2. optimal binding of STAGA to p53 involves interactions of STAGA subunits TAF9, GCN5, and ADA2b, respectively
      Title: Multivalent binding of p53 to the STAGA complex mediates coactivator recruitment after UV damage.
    3. A novel peptide ligand recognized by tumor-specific CD4+ T regulatory (Treg) cells is a dominant peptide derived from the mutated ARTC1 gene. ARTC1 peptide-activated CD4+ Treg cells suppress proliferation and IL-2 secretion of melanoma-reactive T cells.
      Title: Recognition of a new ARTC1 peptide ligand uniquely expressed in tumor cells by antigen-specific CD4+ regulatory T cells.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0764, MGC90306

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in maintenance of protein location in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of DNA repair NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of RNA splicing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SAGA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SAGA complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    STAGA complex 65 subunit gamma
    Names
    SPT7 like, STAGA complex gamma subunit
    SPTF-associated factor 65 gamma
    STAF65gamma
    STAGA complex 65 gamma subunit
    adenocarcinoma antigen ART1
    suppressor of Ty 7-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282729.2 → NP_001269658.1  STAGA complex 65 subunit gamma isoform a

      See identical proteins and their annotated locations for NP_001269658.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode isoform a.
      Source sequence(s)
      AB018307, AC074091, BC074000, CF528942, DA398215
      Consensus CDS
      CCDS42667.1
      UniProtKB/Swiss-Prot
      B4E3W3, O94864, Q6IB21, Q9H2T6
      Conserved Domains (1) summary
      smart00576
      Location:151 → 226
      BTP; Bromodomain transcription factors and PHD domain containing proteins

    2. NM_001282730.2 → NP_001269659.1  STAGA complex 65 subunit gamma isoform b

      See identical proteins and their annotated locations for NP_001269659.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR and uses an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a. Both variants 3 and 4 encode isoform b.
      Source sequence(s)
      AB018307, AC074091, BC045638, CF528942, DA398215
      Consensus CDS
      CCDS62885.1
      UniProtKB/Swiss-Prot
      O94864
      Related
      ENSP00000384469.1, ENST00000405491.5
      Conserved Domains (1) summary
      smart00576
      Location:149 → 224
      BTP; Bromodomain transcription factors and PHD domain containing proteins

    3. NM_001282731.2 → NP_001269660.1  STAGA complex 65 subunit gamma isoform b

      See identical proteins and their annotated locations for NP_001269660.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in its 5' UTR and uses an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a. Both variants 3 and 4 encode isoform b.
      Source sequence(s)
      AB018307, AC074091, AF197954, BI755200, CF528942, DA001757
      Consensus CDS
      CCDS62885.1
      UniProtKB/Swiss-Prot
      O94864
      Conserved Domains (1) summary
      smart00576
      Location:149 → 224
      BTP; Bromodomain transcription factors and PHD domain containing proteins

    4. NM_001282732.2 → NP_001269661.1  STAGA complex 65 subunit gamma isoform c

      See identical proteins and their annotated locations for NP_001269661.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.
      Source sequence(s)
      AB018307, AC074091, AK304889, CF528942
      Consensus CDS
      CCDS62886.1
      UniProtKB/Swiss-Prot
      O94864
      Related
      ENSP00000385218.2, ENST00000404798.6
      Conserved Domains (1) summary
      smart00576
      Location:16 → 91
      BTP; Bromodomain transcription factors and PHD domain containing proteins

    5. NM_014860.3 → NP_055675.1  STAGA complex 65 subunit gamma isoform a

      See identical proteins and their annotated locations for NP_055675.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Both variants 1 and 2 encode isoform a.
      Source sequence(s)
      AB018307, AC074091, AF197954, CF528942, DA398215
      Consensus CDS
      CCDS42667.1
      UniProtKB/Swiss-Prot
      B4E3W3, O94864, Q6IB21, Q9H2T6
      Related
      ENSP00000336750.5, ENST00000337768.10
      Conserved Domains (1) summary
      smart00576
      Location:151 → 226
      BTP; Bromodomain transcription factors and PHD domain containing proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      27642568..27663614 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005264672.5 → XP_005264729.1  STAGA complex 65 subunit gamma isoform X1

      See identical proteins and their annotated locations for XP_005264729.1

      UniProtKB/Swiss-Prot
      O94864
      Conserved Domains (1) summary
      smart00576
      Location:149 → 224
      BTP; Bromodomain transcription factors and PHD domain containing proteins

    RNA

    1. XR_939750.4 RNA Sequence

    2. XR_007085624.1 RNA Sequence

    3. XR_007085611.1 RNA Sequence

    4. XR_007085617.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      27685653..27706702 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344774.1 → XP_054200749.1  STAGA complex 65 subunit gamma isoform X1

    RNA

    1. XR_008486607.1 RNA Sequence

    2. XR_008486610.1 RNA Sequence

    3. XR_008486608.1 RNA Sequence

    4. XR_008486609.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O94864.1 GenPept UniProtKB/Swiss-Prot:O94864

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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