Rtn1 reticulon 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rtn1provided by RGD
Official Full Name: reticulon 1provided by RGD
Primary source: RGD:620986
See related: Ensembl:ENSRNOG00000004794 AllianceGenome:RGD:620986
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nsp
Summary: Predicted to be involved in negative regulation of amyloid-beta formation and neuron differentiation. Located in smooth endoplasmic reticulum. Orthologous to human RTN1 (reticulon 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 780.3) and Spleen (RPKM 36.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 6q24

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (96499137..96719340, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (90763212..90983436, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (94951016..95177477, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RTN1-C mediates cerebral ischemia/reperfusion injury via modulating autophagy.
Title: RTN1-C mediates cerebral ischemia/reperfusion injury via modulating autophagy.
High glucose significantly increases RTN1-C expression in OGD/R-treated cells. RTN1-C affects high glucose-treated OGD/R cells by exacerbating ER stress.
Title: RTN1-C is involved in high glucose-aggravated neuronal cell subjected to oxygen-glucose deprivation and reoxygenation injury via endoplasmic reticulum stress.
Knock-down of RTN1-c protected neurons against traumatic neuronal injury via preservation of calcium homeostasis.
Title: Knockdown of RTN1-C attenuates traumatic neuronal injury through regulating intracellular Ca(2+) homeostasis.
Collectively, these data support for the first time that RTN1-C may represent a novel candidate for therapies against cerebral ischemia/reperfusion injury.
Title: RTN1-C mediates cerebral ischemia/reperfusion injury via ER stress and mitochondria-associated apoptosis pathways.
This study identified the intracellular calcium release channel ryanodine receptor 2 as a direct binding partner of RTN1A.
Title: Direct association of the reticulon protein RTN1A with the ryanodine receptor 2 in neurons.
neuroendocrine-specific protein-A (NSP-A) as ethanol-responsive gene in the fetal rat brain
Title: Differential display identifies neuroendocrine-specific protein-A (NSP-A) and interferon-inducible protein 10 (IP-10) as ethanol-responsive genes in the fetal rat brain.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU048830 (e-PCR)
- UniSTS:145280

D6Rat124 (e-PCR), detects polymorphism
- UniSTS:227987

RH130382 (e-PCR)
- UniSTS:213666

Rtn1 (e-PCR), detects polymorphism
- UniSTS:547529

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum tubular network formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of amyloid-beta formation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of amyloid-beta formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of amyloid-beta formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in smooth endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: reticulon-1

Names: S-rex; neuroendocrine-specific protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053865.2 → NP_446317.2 reticulon-1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

Q64547, Q64548

UniProtKB/TrEMBL

A0A8I6GGJ4

Related

ENSRNOP00000087943.1, ENSRNOT00000118381.1

Conserved Domains (1) summary

PHA03307
Location:310 → 583

PHA03307; transcriptional regulator ICP4; Provisional