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    Galnt18 polypeptide N-acetylgalactosaminyltransferase 18 [ Mus musculus (house mouse) ]

    Gene ID: 233733, updated on 12-May-2024

    Summary

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    Official Symbol
    Galnt18provided by MGI
    Official Full Name
    polypeptide N-acetylgalactosaminyltransferase 18provided by MGI
    Primary source
    MGI:MGI:2446239
    See related
    Ensembl:ENSMUSG00000038296 AllianceGenome:MGI:2446239
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Galntl4; galNAc-T18; 2900011G21Rik; mpp-GalNAc-T18(O18)
    Summary
    Predicted to enable polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including alimentary system; central nervous system; cranium; respiratory system; and sensory organ. Orthologous to human GALNT18 (polypeptide N-acetylgalactosaminyltransferase 18). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in lung adult (RPKM 56.9), genital fat pad adult (RPKM 13.8) and 17 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Galnt18 in Genome Data Viewer
    Location:
    7 E3- F1; 7 58.19 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (111070863..111379274, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (111471656..111780067, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_19844 Neighboring gene predicted gene, 33145 Neighboring gene STARR-seq mESC enhancer starr_19845 Neighboring gene STARR-seq mESC enhancer starr_19846 Neighboring gene high mobility group box 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_19847 Neighboring gene STARR-seq mESC enhancer starr_19848 Neighboring gene high mobility group protein B1 pseudogene Neighboring gene predicted gene, 23345

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The role of mucin-type O-glycans in eukaryotic development. Tabak LA. Semin Cell Dev Biol, 2010 Aug. PMID 20144722, Free PMC Article
    2. Recent insights into the biological roles of mucin-type O-glycosylation. Tian E, et al. Glycoconj J, 2009 Apr. PMID 18695988, Free PMC Article
    3. UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferases: completion of the family tree. Raman J, et al. Glycobiology, 2012 Jun. PMID 22186971, Free PMC Article
    4. Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding. Tian E, et al. Proc Natl Acad Sci U S A, 2019 Dec 10. PMID 31740596, Free PMC Article
    5. Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome. Peluso G, et al. J Biol Chem, 2020 Jan 31. PMID 31882545, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC32465

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    polypeptide N-acetylgalactosaminyltransferase 18
    Names
    UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 4
    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 18
    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 4
    galNAc-T-like protein 4
    polypeptide GalNAc transferase 18
    polypeptide GalNAc transferase-like protein 4
    pp-GaNTase-like protein 4
    protein-UDP acetylgalactosaminyltransferase-like protein 4
    NP_001347832.1
    NP_776100.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360903.1 → NP_001347832.1  polypeptide N-acetylgalactosaminyltransferase 18 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AB175685, AC138151, AC139943, AW124105
      Consensus CDS
      CCDS90311.1
      UniProtKB/TrEMBL
      Q59J91
      Related
      ENSMUSP00000102274.2, ENSMUST00000106663.2
      Conserved Domains (2) summary
      cd02510
      Location:157 → 458
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      cd00161
      Location:471 → 598
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...

    2. NM_173739.4 → NP_776100.2  polypeptide N-acetylgalactosaminyltransferase 18 isoform 1

      See identical proteins and their annotated locations for NP_776100.2

      Status: VALIDATED

      Source sequence(s)
      AA611977, AC132425, AC138151, AC139943, AW124105, BM948475, BQ830603
      Consensus CDS
      CCDS21751.1
      UniProtKB/Swiss-Prot
      Q8K1B9
      Related
      ENSMUSP00000043636.9, ENSMUST00000049430.15
      Conserved Domains (3) summary
      cd02510
      Location:157 → 473
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      cd00161
      Location:486 → 613
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:484 → 611
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      111070863..111379274 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003946460.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K1B9.1 GenPept UniProtKB/Swiss-Prot:Q8K1B9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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