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    hsd20b2 hydroxysteroid (20-beta) dehydrogenase 2 [ Danio rerio (zebrafish) ]

    Gene ID: 368367, updated on 5-May-2024

    Summary

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    Official Symbol
    hsd20b2provided by ZNC
    Official Full Name
    hydroxysteroid (20-beta) dehydrogenase 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030804-21
    See related
    Ensembl:ENSDARG00000031336 AllianceGenome:ZFIN:ZDB-GENE-030804-21
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sb:cb620; si:ch211-284e13.2
    Summary
    Enables androstan-3-alpha,17-beta-diol dehydrogenase activity. Acts upstream of or within multicellular organismal response to stress. Located in endoplasmic reticulum. Is expressed in several structures, including gill; heart; liver; pleuroperitoneal region; and sensory system. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See hsd20b2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (38200780..38214123)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (37600625..37613502)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101885499 Neighboring gene uncharacterized LOC103911093 Neighboring gene si:ch211-284e13.9 Neighboring gene solute carrier family 12 member 9 Neighboring gene zinc finger and SCAN domain-containing protein 5B-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Substrate multispecificity among 20β-hydroxysteroid dehydrogenase type 2 members. Tokarz J, et al. Mol Cell Endocrinol, 2020 Jun 15. PMID 32315721
    2. Zebrafish 20β-hydroxysteroid dehydrogenase type 2 is important for glucocorticoid catabolism in stress response. Tokarz J, et al. PLoS One, 2013. PMID 23349977, Free PMC Article
    3. Discovery of a novel enzyme mediating glucocorticoid catabolism in fish: 20beta-hydroxysteroid dehydrogenase type 2. Tokarz J, et al. Mol Cell Endocrinol, 2012 Feb 26. PMID 22061621
    4. Impairment of the cortisol stress response mediated by the hypothalamus-pituitary-interrenal (HPI) axis in zebrafish (Danio rerio) exposed to monocrotophos pesticide. Zhang X, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2015 Oct-Nov. PMID 26196239
    5. Long-term exposure of zebrafish to bisphenol S impairs stress function of hypothalamic-pituitary-interrenal axis and causes anxiety-like behavioral responses to novelty. Wei P, et al. Sci Total Environ, 2020 May 10. PMID 32044495

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables androstan-3-alpha,17-beta-diol dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within multicellular organismal response to stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    hydroxysteroid (20-beta) dehydrogenase 2; very-long-chain 3-oxoacyl-CoA reductase
    Names
    20beta-hydroxysteroid dehydrogenase type 2
    SDR12C55

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001386628.1 → NP_001373557.1  hydroxysteroid (20-beta) dehydrogenase 2

      Status: VALIDATED

      Source sequence(s)
      BX294181
      UniProtKB/TrEMBL
      A0A088Q715, A2BFP6
      Conserved Domains (1) summary
      cd05356
      Location:54 → 296
      17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      38200780..38214123
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021476561.1 → XP_021332236.1  very-long-chain 3-oxoacyl-CoA reductase

      Related
      ENSDARP00000091542.4, ENSDART00000100769.5
      Conserved Domains (1) summary
      cd05356
      Location:54 → 296
      17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394596.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      353022..366365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_689815.6 → XP_694907.4  very-long-chain 3-oxoacyl-CoA reductase

      UniProtKB/TrEMBL
      A2BFP6
      Conserved Domains (1) summary
      cd05356
      Location:54 → 296
      17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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