hwa huluwa [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hwaprovided by ZNC
Official Full Name: huluwaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-091204-94
See related: Ensembl:ENSDARG00000094542 AllianceGenome:ZFIN:ZDB-GENE-091204-94
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-121h17.7
Summary: Involved in embryonic axis specification; positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification; and protein destabilization. Acts upstream of or within regulation of canonical Wnt signaling pathway. Is active in plasma membrane. Is expressed in blastomere and oocyte stage I. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 21

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (5191797..5198106)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (5027418..5033741)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

maternal Huluwa is an essential determinant of the dorsal organizer and body axis in vertebrate embryos.
Title: Maternal Huluwa dictates the embryonic body axis through β-catenin in vertebrates.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in dorsal/ventral pattern formation	IDA Inferred from Direct Assay more info	PubMed
involved_in embryonic axis specification	IDA Inferred from Direct Assay more info	PubMed
involved_in protein destabilization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein huluwa; uncharacterized protein si:dkey-121h17.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.