ddx17 DEAD-box helicase 17 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ddx17provided by ZNC
Official Full Name: DEAD-box helicase 17provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-18
See related: Ensembl:ENSDARG00000010873 AllianceGenome:ZFIN:ZDB-GENE-030131-18
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zeh0176; hm:zeh0176; si:dkey-156n14.5
Summary: Predicted to enable RNA binding activity and RNA helicase activity. Predicted to be involved in alternative mRNA splicing, via spliceosome. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleus. Orthologous to human DDX17 (DEAD-box helicase 17). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (22104857..22119697)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (20044635..20059475)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb53d08.x1 (e-PCR)
- UniSTS:203305

AI496951 (e-PCR)
- UniSTS:206377

fb33h10.x1 (e-PCR)
- UniSTS:203127

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables ribonucleoprotein complex binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: probable ATP-dependent RNA helicase DDX17

Names: DEAD box polypeptide 17

NP_001313320.1

EC 3.6.4.13

XP_005166300.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001326391.1 → NP_001313320.1 probable ATP-dependent RNA helicase DDX17

Status: VALIDATED

Source sequence(s)

CR626864, EB930015, EB948389

UniProtKB/TrEMBL

A0A8M1P2L5, F1QBS1

Related

ENSDARP00000106130.2, ENSDART00000129202.4

Conserved Domains (3) summary

COG0513
Location:68 → 574

SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

cd00079
Location:313 → 445

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cd00268
Location:97 → 302

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007117.7 Reference GRCz11 Primary Assembly

Range

22104857..22119697

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005166243.4 → XP_005166300.1 probable ATP-dependent RNA helicase DDX17 isoform X1

UniProtKB/TrEMBL

A0A8M2BDR5, F1RBJ8, I3ISW2

Related

ENSDARP00000126010.1, ENSDART00000151747.2

Conserved Domains (3) summary

smart00487
Location:114 → 317

DEXDc; DEAD-like helicases superfamily

cd00268
Location:97 → 302

DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

pfam00271
Location:327 → 406

Helicase_C; Helicase conserved C-terminal domain