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    TIMM10 translocase of inner mitochondrial membrane 10 [ Homo sapiens (human) ]

    Gene ID: 26519, updated on 5-Mar-2024

    Summary

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    Official Symbol
    TIMM10provided by HGNC
    Official Full Name
    translocase of inner mitochondrial membrane 10provided by HGNC
    Primary source
    HGNC:HGNC:11814
    See related
    Ensembl:ENSG00000134809 MIM:602251; AllianceGenome:HGNC:11814
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TIM10; TIM10A; TIMM10A
    Summary
    The mitochondrial protein encoded by this gene belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane, functioning as intermembrane space chaperones for the highly insoluble carrier proteins. [provided by RefSeq, Nov 2011]
    Expression
    Ubiquitous expression in kidney (RPKM 18.4), liver (RPKM 14.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TIMM10 in Genome Data Viewer
    Location:
    11q12.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (57528464..57530754, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (57478642..57492843, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (57295937..57298227, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:57256964-57257464 Neighboring gene solute carrier family 43 member 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:57260708-57261907 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57267535-57268310 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57268311-57269084 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4719 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:57293175-57293772 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4720 Neighboring gene RNA, 7SL, cytoplasmic 605, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:57310876-57311766 Neighboring gene smoothelin like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4721 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4722 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4723 Neighboring gene ubiquitin conjugating enzyme E2 L6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4724 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3351

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of novel genes expressed during rhabdomyosarcoma differentiation using cDNA microarrays. Carey KA, et al. Pathol Int, 2006 May. PMID 16669873
    2. Juxtaposition of the two distal CX3C motifs via intrachain disulfide bonding is essential for the folding of Tim10. Allen S, et al. J Biol Chem, 2003 Oct 3. PMID 12882976
    3. Assembly of Tim9 and Tim10 into a functional chaperone. Vial S, et al. J Biol Chem, 2002 Sep 27. PMID 12138093
    4. Import of mitochondrial carriers mediated by essential proteins of the intermembrane space. Koehler CM, et al. Science, 1998 Jan 16. PMID 9430585
    5. Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria. Rothbauer U, et al. J Biol Chem, 2001 Oct 5. PMID 11489896

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
    2. The crystal structure of TIM9.10 described here reveals a previously undescribed alpha-propeller topology in which helical "blades" radiate from a narrow central pore lined with polar residues.
      Title: Crystal structure of the mitochondrial chaperone TIM9.10 reveals a six-bladed alpha-propeller.
    3. Marked differences in the expression of PTMA and Tim10 were observed during the differentiation of human primary skeletal muscle cells.
      Title: Identification of novel genes expressed during rhabdomyosarcoma differentiation using cDNA microarrays.
    4. in contrast to yeast, only a small fraction of Tim9-Tim10a-Tim10b complex is in a stable association with Tim22
      Title: Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human translocase of inner mitochondrial membrane 10 homolog (yeast) (TIMM10) at amino acid residues 72-73 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables membrane insertase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-folding chaperone binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein insertion into mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein insertion into mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein insertion into mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in protein insertion into mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein targeting to mitochondrion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in sensory perception of sound TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of TIM22 mitochondrial import inner membrane insertion complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of TIM23 mitochondrial import inner membrane translocase complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial intermembrane space NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrial intermembrane space TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of mitochondrial intermembrane space protein transporter complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mitochondrial intermembrane space protein transporter complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial import inner membrane translocase subunit Tim10
    Names
    translocase of inner mitochondrial membrane 10 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012456.3 → NP_036588.1  mitochondrial import inner membrane translocase subunit Tim10

      See identical proteins and their annotated locations for NP_036588.1

      Status: REVIEWED

      Source sequence(s)
      AF150089, AI498204, CB106298
      Consensus CDS
      CCDS7959.1
      UniProtKB/Swiss-Prot
      A8K136, P62072, Q9WV99, Q9WVA0, Q9Y5J8
      Related
      ENSP00000257245.4, ENST00000257245.9
      Conserved Domains (1) summary
      pfam02953
      Location:7 → 69
      zf-Tim10_DDP; Tim10/DDP family zinc finger

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      57528464..57530754 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448436.2 → XP_024304204.1  mitochondrial import inner membrane translocase subunit Tim10 isoform X1

      UniProtKB/Swiss-Prot
      A8K136, P62072, Q9WV99, Q9WVA0, Q9Y5J8
      Related
      ENSP00000433627.1, ENST00000525158.1
      Conserved Domains (1) summary
      pfam02953
      Location:7 → 69
      zf-Tim10_DDP; Tim10/DDP family zinc finger

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      57478642..57492843 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368410.1 → XP_054224385.1  mitochondrial import inner membrane translocase subunit Tim10 isoform X1

      UniProtKB/Swiss-Prot
      A8K136, P62072, Q9WV99, Q9WVA0, Q9Y5J8

    2. XM_054368409.1 → XP_054224384.1  mitochondrial import inner membrane translocase subunit Tim10 isoform X1

      UniProtKB/Swiss-Prot
      A8K136, P62072, Q9WV99, Q9WVA0, Q9Y5J8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62072.1 GenPept UniProtKB/Swiss-Prot:P62072

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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