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    LYRM2 LYR motif containing 2 [ Homo sapiens (human) ]

    Gene ID: 57226, updated on 5-Mar-2024

    Summary

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    Official Symbol
    LYRM2provided by HGNC
    Official Full Name
    LYR motif containing 2provided by HGNC
    Primary source
    HGNC:HGNC:25229
    See related
    Ensembl:ENSG00000083099 AllianceGenome:HGNC:25229
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DJ122O8.2
    Expression
    Ubiquitous expression in brain (RPKM 12.5), thyroid (RPKM 12.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See LYRM2 in Genome Data Viewer
    Location:
    6q15
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (89632224..89638747, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (90841594..90848122, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (90341943..90348466, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 6 Neighboring gene uncharacterized LOC105377889 Neighboring gene OCT4 hESC enhancer GRCh37_chr6:90262750-90263251 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:90265242-90265742 Neighboring gene uncharacterized LOC124901359 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:90319101-90319300 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:90347214-90348413 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:90367565-90368764 Neighboring gene MDN1 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 852 Neighboring gene midasin AAA ATPase 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:90399309-90399858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:90405104-90405604 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:90405605-90406105 Neighboring gene NANOG hESC enhancer GRCh37_chr6:90430881-90431382 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:90509087-90509820 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:90510674-90511174 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:90511175-90511675 Neighboring gene DnaJ heat shock protein family (Hsp40) member C19 pseudogene 6 Neighboring gene PIMREG pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LYRM2 directly regulates complex I activity to support tumor growth in colorectal cancer by oxidative phosphorylation. Huang Q, et al. Cancer Lett, 2019 Jul 28. PMID 31004700
    2. The Mitochondrial Acyl-carrier Protein Interaction Network Highlights Important Roles for LYRM Family Members in Complex I and Mitoribosome Assembly. Dibley MG, et al. Mol Cell Proteomics, 2020 Jan. PMID 31666358, Free PMC Article
    3. Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening. Robertson NG, et al. Genomics, 1994 Sep 1. PMID 7829101
    4. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. Floyd BJ, et al. Mol Cell, 2016 Aug 18. PMID 27499296, Free PMC Article
    5. Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis. Moutaoufik MT, et al. iScience, 2019 Sep 27. PMID 31536960, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Authors identified a new Akt-S58phos-LYRM2-Complex I axis, which is responsible for the LYRM2-induced tumor growth and the activation of OXPHOS in colorectal cancer.
      Title: LYRM2 directly regulates complex I activity to support tumor growth in colorectal cancer by oxidative phosphorylation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ18193, FLJ18317, FLJ21130, MGC104253

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial respiratory chain complex I assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    LYR motif-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020466.5 → NP_065199.1  LYR motif-containing protein 2

      See identical proteins and their annotated locations for NP_065199.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the functional protein.
      Source sequence(s)
      AL096678, BC104668, BI492982, BP280644
      Consensus CDS
      CCDS5023.1
      UniProtKB/Swiss-Prot
      B2R4U2, E1P517, Q9NU23
      Related
      ENSP00000430025.1, ENST00000523377.2
      Conserved Domains (1) summary
      pfam05347
      Location:20 → 78
      Complex1_LYR; Complex 1 protein (LYR family)

    RNA

    1. NR_028493.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' exon and uses an alternate splice site in an internal exon, compared to variant 1. This variant lacks the translational start codon, as found in variant 1, and it does not appear to be protein-coding.
      Source sequence(s)
      AK094994, AL096678, BI492982, DA160441

    2. NR_028494.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' exon, compared to variant 1. This variant lacks the translational start codon, as found in variant 1, and it does not appear to be protein-coding.
      Source sequence(s)
      AK311180, AL096678, BI492982, DA160441

    3. NR_028495.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate 5' exon, compared to variant 1. This variant lacks the translational start codon, as found in variant 1, and it does not appear to be protein-coding.
      Source sequence(s)
      AL096678, AV710669, BI492982

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      89632224..89638747 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      90841594..90848122 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NU23.1 GenPept UniProtKB/Swiss-Prot:Q9NU23

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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