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    Rps18 ribosomal protein S18 [ Mus musculus (house mouse) ]

    Gene ID: 20084, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rps18provided by MGI
    Official Full Name
    ribosomal protein S18provided by MGI
    Primary source
    MGI:MGI:98146
    See related
    Ensembl:ENSMUSG00000008668 AllianceGenome:MGI:98146
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ke3; Ke-3; H-2Ke3; H2-Ke3
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Is active in synapse. Is expressed in several structures, including brain; genitourinary system; heart; hemolymphoid system gland; and liver. Orthologous to human RPS18 (ribosomal protein S18). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14 (RPKM 498.9), liver E18 (RPKM 438.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 B1; 17 17.98 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34170972..34174639, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33951998..33955665, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1938 Neighboring gene WD repeat domain 46 Neighboring gene STARR-positive B cell enhancer ABC_E8668 Neighboring gene UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 Neighboring gene STARR-positive B cell enhancer ABC_E3199 Neighboring gene VPS52 GARP complex subunit Neighboring gene predicted gene, 23111 Neighboring gene STARR-positive B cell enhancer ABC_E2483 Neighboring gene histocompatibility 2, K region locus 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Search for MHC-associated genes in human: five new genes centromeric to HLA-DP with yet unknown functions. Janatipour M, et al. Immunogenetics, 1992. PMID 1541487
    2. Expression of a gene trap reporter construct in a subset of cells in embryonic sites of hematopoiesis: evidence for alternative rRNA production in hematopoietic cells. Wagner DS, et al. Biochem Biophys Res Commun, 1998 Sep 29. PMID 9784405
    3. Processing of mammalian rRNA precursors at the 3' end of 18S rRNA. Identification of cis-acting signals suggests the involvement of U13 small nucleolar RNA. Cavaillé J, et al. Eur J Biochem, 1996 Dec 1. PMID 8973634
    4. Impaired bone formation in Pdia3 deficient mice. Wang Y, et al. PLoS One, 2014. PMID 25405762, Free PMC Article
    5. The murine MHC encodes a mammalian homolog of bacterial ribosomal protein S13. MacMurray AJ, et al. Mamm Genome, 1992. PMID 1543907

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic small ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in ribosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    small ribosomal subunit protein uS13
    Names
    40S ribosomal protein S18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011296.3 → NP_035426.1  small ribosomal subunit protein uS13

      See identical proteins and their annotated locations for NP_035426.1

      Status: VALIDATED

      Source sequence(s)
      CR974462
      Consensus CDS
      CCDS37573.1
      UniProtKB/Swiss-Prot
      P62270
      UniProtKB/TrEMBL
      Q3TW65, Q561N5
      Related
      ENSMUSP00000008812.8, ENSMUST00000008812.9
      Conserved Domains (1) summary
      PTZ00134
      Location:1 → 152
      PTZ00134; 40S ribosomal protein S18; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      34170972..34174639 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_138946.1: Suppressed sequence

      Description
      NM_138946.1: This RefSeq was permanently suppressed because it was entirely composed of intronic sequence.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62270.3 GenPept UniProtKB/Swiss-Prot:P62270

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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