Zfp365 zinc finger protein 365 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp365provided by MGI
Official Full Name: zinc finger protein 365provided by MGI
Primary source: MGI:MGI:2143676
See related: Ensembl:ENSMUSG00000037855 AllianceGenome:MGI:2143676
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DBZ; Su48; Znf365; talanin
Summary: Predicted to enable protein homodimerization activity. Involved in nervous system development and telomere maintenance. Predicted to be located in centrosome and intracellular membrane-bounded organelle. Predicted to be active in centriolar satellite. Is expressed in brain; embryo; and lens. Human ortholog(s) of this gene implicated in uric acid nephrolithiasis. Orthologous to human ZNF365 (zinc finger protein 365). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 80.2), frontal lobe adult (RPKM 65.7) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 10 B5.1; 10 35.04 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (67721935..67748492, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (67886105..67912662, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lack of ZNF365 Drives Senescence and Exacerbates Experimental Lung Fibrosis.
Title: Lack of ZNF365 Drives Senescence and Exacerbates Experimental Lung Fibrosis.
The oligodendrocyte differentiation in rodents was determined to be regulated by DBZ.
Title: DBZ, a CNS-specific DISC1 binding protein, positively regulates oligodendrocyte differentiation.
These findings show that DBZ is involved in the morphogenesis of basket cells.
Title: DBZ (DISC1-binding zinc finger protein)-deficient mice display abnormalities in basket cells in the somatosensory cortices.
These results suggest an homologous recombination repair-dependent function of ZNF365 in preventing genomic instability.
Title: ZNF365 promotes stalled replication forks recovery to maintain genome stability.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

General gene information

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Markers

Zfp365 (e-PCR), detects polymorphism
- UniSTS:497464

AV340892 (e-PCR)
- UniSTS:180047

AI839779 (e-PCR)
- UniSTS:164439

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in cerebellar molecular layer morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite arborization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gamma-tubulin complex localization	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within mitotic cytokinesis	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA strand resection involved in replication fork processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA strand resection involved in replication fork processing	ISO Inferred from Sequence Orthology more info
involved_in regulation of double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere maintenance	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomere maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telomere maintenance	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centrosome	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein ZNF365

Names: DISC1-binding zinc-finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.