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    Dcun1d3 defective in cullin neddylation 1 domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 233805, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Dcun1d3provided by MGI
    Official Full Name
    defective in cullin neddylation 1 domain containing 3provided by MGI
    Primary source
    MGI:MGI:2679003
    See related
    Ensembl:ENSMUSG00000048787 AllianceGenome:MGI:2679003
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DCNL3; SCCRO3; 1700020A13Rik
    Summary
    Predicted to enable cullin family protein binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin-like protein binding activity. Predicted to be involved in several processes, including protein neddylation; regulation of protein modification by small protein conjugation or removal; and response to UV-C. Predicted to be located in nucleus; perinuclear region of cytoplasm; and plasma membrane. Predicted to be part of ubiquitin ligase complex. Is expressed in genitourinary system. Orthologous to human DCUN1D3 (defective in cullin neddylation 1 domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 6.8), bladder adult (RPKM 2.7) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dcun1d3 in Genome Data Viewer
    Location:
    7 F2; 7 64.27 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (119452381..119495553, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (119853158..119896330, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57786 Neighboring gene acyl-CoA synthetase medium-chain family member 3 Neighboring gene exoribonuclease 2 Neighboring gene RNA exonuclease 5 Neighboring gene STARR-seq mESC enhancer starr_20039 Neighboring gene STARR-positive B cell enhancer ABC_E3747 Neighboring gene STARR-seq mESC enhancer starr_20040 Neighboring gene LYR motif containing 1 Neighboring gene STARR-seq mESC enhancer starr_20041 Neighboring gene dynein, axonemal, heavy chain 3 Neighboring gene predicted gene, 53369 Neighboring gene predicted gene, 25217

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
    2. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
    3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Thompson CL, et al. Neuron, 2014 Jul 16. PMID 24952961, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC40975

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cullin family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-like protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein neddylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein neddylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein neddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell cycle process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein neddylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to UV-C ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to gamma radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DCN1-like protein 3
    Names
    DCN1, defective in cullin neddylation 1, domain containing 3
    DCUN1 domain-containing protein 3
    defective in cullin neddylation protein 1-like protein 3
    squamous cell carcinoma-related oncogene 3
    NP_001157175.1
    NP_775584.1
    XP_006507744.1
    XP_011240050.1
    XP_011240051.1
    XP_011240053.1
    XP_036008898.1
    XP_036008899.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163703.1 → NP_001157175.1  DCN1-like protein 3

      See identical proteins and their annotated locations for NP_001157175.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC122423, AC131702
      Consensus CDS
      CCDS21789.1
      UniProtKB/Swiss-Prot
      Q8K0V2
      Related
      ENSMUSP00000058968.7, ENSMUST00000059851.14
      Conserved Domains (1) summary
      pfam03556
      Location:164 → 276
      Cullin_binding; Cullin binding

    2. NM_173408.3 → NP_775584.1  DCN1-like protein 3

      See identical proteins and their annotated locations for NP_775584.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC122423, AC131702
      Consensus CDS
      CCDS21789.1
      UniProtKB/Swiss-Prot
      Q8K0V2
      Related
      ENSMUSP00000095686.3, ENSMUST00000098080.9
      Conserved Domains (1) summary
      pfam03556
      Location:164 → 276
      Cullin_binding; Cullin binding

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      119452381..119495553 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241751.2 → XP_011240053.1  DCN1-like protein 3 isoform X1

      See identical proteins and their annotated locations for XP_011240053.1

      UniProtKB/Swiss-Prot
      Q8K0V2
      Conserved Domains (1) summary
      pfam03556
      Location:164 → 276
      Cullin_binding; Cullin binding

    2. XM_011241749.2 → XP_011240051.1  DCN1-like protein 3 isoform X1

      See identical proteins and their annotated locations for XP_011240051.1

      UniProtKB/Swiss-Prot
      Q8K0V2
      Related
      ENSMUSP00000102129.2, ENSMUST00000106519.8
      Conserved Domains (1) summary
      pfam03556
      Location:164 → 276
      Cullin_binding; Cullin binding

    3. XM_036153005.1 → XP_036008898.1  DCN1-like protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q8K0V2
      Conserved Domains (1) summary
      pfam03556
      Location:164 → 276
      Cullin_binding; Cullin binding

    4. XM_036153006.1 → XP_036008899.1  DCN1-like protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q8K0V2
      Conserved Domains (1) summary
      pfam03556
      Location:164 → 276
      Cullin_binding; Cullin binding

    5. XM_011241748.4 → XP_011240050.1  DCN1-like protein 3 isoform X1

      See identical proteins and their annotated locations for XP_011240050.1

      UniProtKB/Swiss-Prot
      Q8K0V2
      Conserved Domains (1) summary
      pfam03556
      Location:164 → 276
      Cullin_binding; Cullin binding

    6. XM_006507681.4 → XP_006507744.1  DCN1-like protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006507744.1

      UniProtKB/Swiss-Prot
      Q8K0V2
      Conserved Domains (1) summary
      pfam03556
      Location:164 → 276
      Cullin_binding; Cullin binding
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K0V2.1 GenPept UniProtKB/Swiss-Prot:Q8K0V2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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