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    Med17 mediator complex subunit 17 [ Mus musculus (house mouse) ]

    Gene ID: 234959, updated on 5-Apr-2024

    Summary

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    Official Symbol
    Med17provided by MGI
    Official Full Name
    mediator complex subunit 17provided by MGI
    Primary source
    MGI:MGI:2182585
    See related
    Ensembl:ENSMUSG00000031935 AllianceGenome:MGI:2182585
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    77kDa; Crsp6; Trap80; C330002H14Rik
    Summary
    Predicted to enable nuclear receptor coactivator activity and thyroid hormone receptor binding activity. Acts upstream of or within stem cell population maintenance. Part of mediator complex. Is expressed in female associated reproductive structure; limb mesenchyme; male associated reproductive structure; ovary; and testis. Human ortholog(s) of this gene implicated in infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly. Orthologous to human MED17 (mediator complex subunit 17). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in placenta adult (RPKM 6.0), ovary adult (RPKM 5.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 A2; 9 4.74 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (15171647..15194576, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (15260351..15279906, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23370 Neighboring gene predicted gene, 39293 Neighboring gene predicted gene, 51702 Neighboring gene V-set and transmembrane domain containing 5 Neighboring gene STARR-seq mESC enhancer starr_23372 Neighboring gene RIKEN cDNA 4931406C07 gene Neighboring gene STARR-positive B cell enhancer ABC_E6715 Neighboring gene TATA-box binding protein associated factor, RNA polymerase I, D Neighboring gene microRNA 7650

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transcriptional activation of lipogenesis by insulin requires phosphorylation of MED17 by CK2. Viscarra JA, et al. Sci Signal, 2017 Feb 21. PMID 28223413, Free PMC Article
    2. Two modes of transcriptional activation at native promoters by NF-kappaB p65. van Essen D, et al. PLoS Biol, 2009 Mar 31. PMID 19338389, Free PMC Article
    3. Mediator complex proximal Tail subunit MED30 is critical for Mediator core stability and cardiomyocyte transcriptional network. Tan C, et al. PLoS Genet, 2021 Sep. PMID 34506481, Free PMC Article
    4. Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Ge K, et al. Nature, 2002 May 30. PMID 12037571
    5. Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors. Malik S, et al. Mol Cell Biol, 2004 Sep. PMID 15340084, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear receptor coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear thyroid hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription elongation by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription initiation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription initiation by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within somatic stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of core mediator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mediator complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mediator of RNA polymerase II transcription subunit 17
    Names
    CRSP complex subunit 6
    cofactor required for Sp1 transcriptional activation, subunit 6 (77kD)
    thyroid hormone receptor-associated protein complex 80 kDa component

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364533.1 → NP_001351462.1  mediator of RNA polymerase II transcription subunit 17 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154296
      Conserved Domains (1) summary
      pfam10156
      Location:123 → 396
      Med17; Subunit 17 of Mediator complex

    2. NM_144933.2 → NP_659182.1  mediator of RNA polymerase II transcription subunit 17 isoform 1

      See identical proteins and their annotated locations for NP_659182.1

      Status: VALIDATED

      Source sequence(s)
      BC020185, CJ078373
      Consensus CDS
      CCDS22834.1
      UniProtKB/Swiss-Prot
      Q8BYS6, Q8VCD5, Q99KQ1
      Related
      ENSMUSP00000034411.9, ENSMUST00000034411.10
      Conserved Domains (1) summary
      pfam10156
      Location:123 → 396
      Med17; Subunit 17 of Mediator complex

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      15171647..15194576 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154859.1 → XP_036010752.1  mediator of RNA polymerase II transcription subunit 17 isoform X1

      Conserved Domains (1) summary
      pfam10156
      Location:50 → 316
      Med17; Subunit 17 of Mediator complex
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCD5.1 GenPept UniProtKB/Swiss-Prot:Q8VCD5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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