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    Zfp84 zinc finger protein 84 [ Mus musculus (house mouse) ]

    Gene ID: 74352, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Zfp84provided by MGI
    Official Full Name
    zinc finger protein 84provided by MGI
    Primary source
    MGI:MGI:107780
    See related
    Ensembl:ENSMUSG00000046185 AllianceGenome:MGI:107780
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp69; KRAB18; 2210410P13Rik; 4633401C23Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in early conceptus; genitourinary system; and limb mesenchyme. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 4.7), CNS E14 (RPKM 4.6) and 27 other tissues See more
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    Genomic context

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    Location:
    7 B1; 7 17.25 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (29467977..29480844)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (29768552..29781419)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23103 Neighboring gene STARR-seq mESC enhancer starr_18485 Neighboring gene predicted gene, 38983 Neighboring gene STARR-positive B cell enhancer ABC_E6530 Neighboring gene microRNA 1964 Neighboring gene STARR-seq mESC enhancer starr_18488 Neighboring gene zinc finger protein 30 Neighboring gene predicted gene 6579

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea. Bellefroid EJ, et al. Proc Natl Acad Sci U S A, 1995 Nov 7. PMID 7479878, Free PMC Article
    2. Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia. Ihle JN, et al. J Virol, 1989 Jul. PMID 2542606, Free PMC Article
    3. Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci. Marine JC, et al. Mamm Genome, 1996 Jun. PMID 8662221
    4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 84
    Names
    zinc finger protein 69

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023750.2 → NP_076239.1  zinc finger protein 84

      See identical proteins and their annotated locations for NP_076239.1

      Status: VALIDATED

      Source sequence(s)
      AC122256, AK034259, AK145426
      Consensus CDS
      CCDS21074.1
      UniProtKB/TrEMBL
      Q9D654
      Related
      ENSMUSP00000032802.5, ENSMUST00000032802.5
      Conserved Domains (5) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box
      COG5048
      Location:243 → 559
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:447 → 467
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:14 → 53
      KRAB; KRAB box
      pfam13465
      Location:515 → 540
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      29467977..29480844
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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