Lifr LIF receptor alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lifrprovided by MGI
Official Full Name: LIF receptor alphaprovided by MGI
Primary source: MGI:MGI:96788
See related: Ensembl:ENSMUSG00000054263 AllianceGenome:MGI:96788
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LIF; A230075M04Rik
Summary: Predicted to enable several functions, including ciliary neurotrophic factor receptor binding activity; growth factor binding activity; and leukemia inhibitory factor receptor activity. Predicted to contribute to ciliary neurotrophic factor receptor activity and oncostatin-M receptor activity. Acts upstream of or within positive regulation of cell population proliferation. Predicted to be located in extracellular region and plasma membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and immune system. Used to study CAKUT. Human ortholog(s) of this gene implicated in osteochondrodysplasia. Orthologous to human LIFR (LIF receptor subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in placenta adult (RPKM 14.4), liver adult (RPKM 13.6) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 A1; 15 3.46 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (7120091..7226970)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (7090610..7197489)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Intrahepatic paracrine signaling by cardiotrophin-like cytokine factor 1 ameliorates diet-induced NASH in mice.
Title: Intrahepatic paracrine signaling by cardiotrophin-like cytokine factor 1 ameliorates diet-induced NASH in mice.
miR-221-3p regulates hepatocellular carcinoma cell proliferation, migration and invasion via targeting LIFR.
Title: miR-221-3p regulates hepatocellular carcinoma cell proliferation, migration and invasion via targeting LIFR.
Concomitant Activation of OSM and LIF Receptor by a Dual-Specific hlOSM Variant Confers Cardioprotection after Myocardial Infarction in Mice.
Title: Concomitant Activation of OSM and LIF Receptor by a Dual-Specific hlOSM Variant Confers Cardioprotection after Myocardial Infarction in Mice.
Uterine Epithelial LIF Receptors Contribute to Implantation Chamber Formation in Blastocyst Attachment.
Title: Uterine Epithelial LIF Receptors Contribute to Implantation Chamber Formation in Blastocyst Attachment.
Inflammation-like changes in the urothelium of Lifr-deficient mice and LIFR-haploinsufficient humans with urinary tract anomalies.
Title: Inflammation-like changes in the urothelium of Lifr-deficient mice and LIFR-haploinsufficient humans with urinary tract anomalies.
Immunization against leukemia inhibitory factor and its receptor suppresses tumor formation of breast cancer initiating cells in BALB/c mouse.
Title: Immunization against leukemia inhibitory factor and its receptor suppresses tumor formation of breast cancer initiating cells in BALB/c mouse.
Sertoli cell LIFR ablation results in a degenerative phenotype, characterised by abnormal germ cell loss, sperm stasis, seminiferous tubule distention and subsequent atrophy of the seminiferous tubules.
Title: Leukemia Inhibitory Factor-Receptor is Dispensable for Prenatal Testis Development but is Required in Sertoli cells for Normal Spermatogenesis in Mice.
Authors demonstrate heterozygous novel or rare LIFR mutations in 3.3% of CAKUT patients, and provide evidence that Lifr deficiency and deactivating LIFR mutations cause highly similar anomalies of the urogenital tract in mice and humans.
Title: Mutations in the leukemia inhibitory factor receptor (LIFR) gene and Lifr deficiency cause urinary tract malformations.
uterine expression of the LIFR is essential for embryo implantation; this further define the components of the LIF signaling pathway necessary for effective implantation.
Title: Tissue-Specific Ablation of the LIF Receptor in the Murine Uterine Epithelium Results in Implantation Failure.
OSM (mOSM) signals mainly via an OSM receptor (OSMR)-gp130 heterodimer and binds with only very low affinity to mLIFR.
Title: Murine Oncostatin M Acts via Leukemia Inhibitory Factor Receptor to Phosphorylate Signal Transducer and Activator of Transcription 3 (STAT3) but Not STAT1, an Effect That Protects Bone Mass.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Lifr (e-PCR), detects polymorphism
- UniSTS:532253

Lifr (e-PCR), detects polymorphism
- UniSTS:143778

AW061234 (e-PCR)
- UniSTS:180732

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to ciliary neurotrophic factor receptor activity	ISO Inferred from Sequence Orthology more info
enables ciliary neurotrophic factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ciliary neurotrophic factor receptor binding	ISO Inferred from Sequence Orthology more info
enables cytokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine binding	ISO Inferred from Sequence Orthology more info
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor binding	ISO Inferred from Sequence Orthology more info
enables leukemia inhibitory factor receptor activity	ISO Inferred from Sequence Orthology more info
contributes_to oncostatin-M receptor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to oncostatin-M receptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in animal organ regeneration	ISO Inferred from Sequence Orthology more info
involved_in ciliary neurotrophic factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in leukemia inhibitory factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in neuron projection morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in oncostatin-M-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in response to cytokine	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: leukemia inhibitory factor receptor

Names: D-factor/LIF receptor; LIF-R; leukemia inhibitory factor receptor alpha chain; soluble differentiation-stimulating factor receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113386.1 → NP_001106857.1 leukemia inhibitory factor receptor isoform 2 precursor

See identical proteins and their annotated locations for NP_001106857.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and includes an alternate exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC104553, AK145864, BY716975

Consensus CDS

CCDS49577.1

UniProtKB/TrEMBL

Q3UKU5

Related

ENSMUSP00000131434.2, ENSMUST00000164529.9

Conserved Domains (4) summary

cd00063
Location:428 → 525

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam17971
Location:126 → 239

LIFR_D2; Leukemia inhibitory factor receptor D2 domain

pfam18207
Location:50 → 124

LIFR_N; Leukemia inhibitory factor receptor N-terminal domain

cl21522
Location:547 → 613

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_001358593.1 → NP_001345522.1 leukemia inhibitory factor receptor isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode the same protein.

Source sequence(s)

AC104553, AC158747

Consensus CDS

CCDS27369.1

UniProtKB/Swiss-Prot

P42703, Q5I0Y2

UniProtKB/TrEMBL

Q3U234

Related

ENSMUSP00000064551.6, ENSMUST00000067190.12

Conserved Domains (4) summary

cd00063
Location:428 → 525

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam17971
Location:126 → 239

LIFR_D2; Leukemia inhibitory factor receptor D2 domain

pfam18207
Location:50 → 124

LIFR_N; Leukemia inhibitory factor receptor N-terminal domain

cl21522
Location:547 → 613

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_013584.2 → NP_038612.1 leukemia inhibitory factor receptor isoform 1 precursor

See identical proteins and their annotated locations for NP_038612.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1). Both variants 1 and 3 encode the same protein.

Source sequence(s)

AC104553, AC158747

Consensus CDS

CCDS27369.1

UniProtKB/Swiss-Prot

P42703, Q5I0Y2

UniProtKB/TrEMBL

Q3U234

Related

ENSMUSP00000154750.2, ENSMUST00000226471.2

Conserved Domains (4) summary

cd00063
Location:428 → 525

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam17971
Location:126 → 239

LIFR_D2; Leukemia inhibitory factor receptor D2 domain

pfam18207
Location:50 → 124

LIFR_N; Leukemia inhibitory factor receptor N-terminal domain

cl21522
Location:547 → 613

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

7120091..7226970

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006519969.4 → XP_006520032.1 leukemia inhibitory factor receptor isoform X1

See identical proteins and their annotated locations for XP_006520032.1

UniProtKB/Swiss-Prot

P42703, Q5I0Y2

UniProtKB/TrEMBL

Q3U234

Conserved Domains (4) summary

cd00063
Location:428 → 525

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam17971
Location:126 → 239

LIFR_D2; Leukemia inhibitory factor receptor D2 domain

pfam18207
Location:50 → 124

LIFR_N; Leukemia inhibitory factor receptor N-terminal domain

cl21522
Location:547 → 613

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_006519970.5 → XP_006520033.1 leukemia inhibitory factor receptor isoform X2

See identical proteins and their annotated locations for XP_006520033.1

UniProtKB/TrEMBL

Q3UKU5

Conserved Domains (4) summary

cd00063
Location:428 → 525

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam17971
Location:126 → 239

LIFR_D2; Leukemia inhibitory factor receptor D2 domain

pfam18207
Location:50 → 124

LIFR_N; Leukemia inhibitory factor receptor N-terminal domain

cl21522
Location:547 → 613

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_006519971.2 → XP_006520034.1 leukemia inhibitory factor receptor isoform X2

See identical proteins and their annotated locations for XP_006520034.1

UniProtKB/TrEMBL

Q3UKU5

Related

ENSMUSP00000154181.2, ENSMUST00000227727.2

Conserved Domains (4) summary

cd00063
Location:428 → 525

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam17971
Location:126 → 239

LIFR_D2; Leukemia inhibitory factor receptor D2 domain

pfam18207
Location:50 → 124

LIFR_N; Leukemia inhibitory factor receptor N-terminal domain

cl21522
Location:547 → 613

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_011245326.4 → XP_011243628.1 leukemia inhibitory factor receptor isoform X1

See identical proteins and their annotated locations for XP_011243628.1

UniProtKB/Swiss-Prot

P42703, Q5I0Y2

UniProtKB/TrEMBL

Q3U234

Conserved Domains (4) summary

cd00063
Location:428 → 525

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam17971
Location:126 → 239

LIFR_D2; Leukemia inhibitory factor receptor D2 domain

pfam18207
Location:50 → 124

LIFR_N; Leukemia inhibitory factor receptor N-terminal domain

cl21522
Location:547 → 613

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...