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    Rhno1 RAD9-HUS1-RAD1 interacting nuclear orphan 1 [ Mus musculus (house mouse) ]

    Gene ID: 72440, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Rhno1provided by MGI
    Official Full Name
    RAD9-HUS1-RAD1 interacting nuclear orphan 1provided by MGI
    Primary source
    MGI:MGI:1915315
    See related
    Ensembl:ENSMUSG00000048668 AllianceGenome:MGI:1915315
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2510047L19Rik; 5930416I19Rik
    Summary
    Predicted to be involved in cellular response to radiation; recombinational repair; and regulation of cell cycle process. Predicted to act upstream of or within cellular response to DNA damage stimulus. Predicted to be active in chromosome and nucleus. Is expressed in midbrain ventricular layer; neural retina; olfactory cortex ventricular layer; renal cortex; and telencephalon ventricular layer. Orthologous to human RHNO1 (RAD9-HUS1-RAD1 interacting nuclear orphan 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 8.3), thymus adult (RPKM 8.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 F3; 6 62.97 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (128333962..128339876, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (128356999..128362911, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L18, pseudogene 2 Neighboring gene STARR-positive B cell enhancer ABC_E8134 Neighboring gene TUB like protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E4867 Neighboring gene forkhead box M1 Neighboring gene STARR-positive B cell enhancer ABC_E8833 Neighboring gene testis expressed 52 Neighboring gene nuclear receptor interacting protein 2 Neighboring gene integrin alpha FG-GAP repeat containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. [RHNO1: A novel noncoding RNA highly expressed in the testis and involved in DNA double-strand break repair]. Gu NH, et al. Zhonghua Nan Ke Xue, 2020 May. PMID 33354946
    2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. [RHNO1: A novel noncoding RNA highly expressed in the testis and involved in DNA double-strand break repair].
      Title: [RHNO1: A novel noncoding RNA highly expressed in the testis and involved in DNA double-strand break repair].
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin-protein adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to UV ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via alternative nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of G0 to G1 transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in recombinational repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in recombinational repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RAD9, HUS1, RAD1-interacting nuclear orphan protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001326583.1 → NP_001313512.1  RAD9, HUS1, RAD1-interacting nuclear orphan protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. All 4 variants encode the same protein.
      Source sequence(s)
      AC116573, AK029454
      Consensus CDS
      CCDS85164.1
      UniProtKB/Swiss-Prot
      Q3U0N5, Q3UK55, Q8K3A4, Q99JS2
      UniProtKB/TrEMBL
      E9Q1D4
      Related
      ENSMUSP00000054573.9, ENSMUST00000057421.15
      Conserved Domains (1) summary
      pfam15319
      Location:1 → 233
      RHINO; RAD9, RAD1, HUS1-interacting nuclear orphan protein

    2. NM_001326585.1 → NP_001313514.1  RAD9, HUS1, RAD1-interacting nuclear orphan protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. All 4 variants encode the same protein.
      Source sequence(s)
      AC116573, BB841580, BE655013
      Consensus CDS
      CCDS85164.1
      UniProtKB/Swiss-Prot
      Q3U0N5, Q3UK55, Q8K3A4, Q99JS2
      UniProtKB/TrEMBL
      E9Q1D4
      Related
      ENSMUSP00000107778.2, ENSMUST00000112151.2
      Conserved Domains (1) summary
      pfam15319
      Location:1 → 233
      RHINO; RAD9, RAD1, HUS1-interacting nuclear orphan protein

    3. NM_001326586.1 → NP_001313515.1  RAD9, HUS1, RAD1-interacting nuclear orphan protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. All 4 variants encode the same protein.
      Source sequence(s)
      AC116573
      Consensus CDS
      CCDS85164.1
      UniProtKB/Swiss-Prot
      Q3U0N5, Q3UK55, Q8K3A4, Q99JS2
      UniProtKB/TrEMBL
      E9Q1D4
      Related
      ENSMUSP00000107779.2, ENSMUST00000112152.8
      Conserved Domains (1) summary
      pfam15319
      Location:1 → 233
      RHINO; RAD9, RAD1, HUS1-interacting nuclear orphan protein

    4. NM_001326587.1 → NP_001313516.1  RAD9, HUS1, RAD1-interacting nuclear orphan protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. All 4 variants encode the same protein.
      Source sequence(s)
      AC116573
      Consensus CDS
      CCDS85164.1
      UniProtKB/Swiss-Prot
      Q3U0N5, Q3UK55, Q8K3A4, Q99JS2
      UniProtKB/TrEMBL
      E9Q1D4
      Conserved Domains (1) summary
      pfam15319
      Location:1 → 233
      RHINO; RAD9, RAD1, HUS1-interacting nuclear orphan protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      128333962..128339876 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152323.1 → XP_036008216.1  RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3U0N5, Q3UK55, Q8K3A4, Q99JS2
      UniProtKB/TrEMBL
      E9Q1D4
      Conserved Domains (1) summary
      pfam15319
      Location:1 → 233
      RHINO; RAD9, RAD1, HUS1-interacting nuclear orphan protein

    2. XM_017321763.2 → XP_017177252.1  RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3U0N5, Q3UK55, Q8K3A4, Q99JS2
      UniProtKB/TrEMBL
      E9Q1D4
      Conserved Domains (1) summary
      pfam15319
      Location:1 → 233
      RHINO; RAD9, RAD1, HUS1-interacting nuclear orphan protein

    3. XM_036152322.1 → XP_036008215.1  RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3U0N5, Q3UK55, Q8K3A4, Q99JS2
      UniProtKB/TrEMBL
      E9Q1D4
      Conserved Domains (1) summary
      pfam15319
      Location:1 → 233
      RHINO; RAD9, RAD1, HUS1-interacting nuclear orphan protein

    4. XM_036152321.1 → XP_036008214.1  RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3U0N5, Q3UK55, Q8K3A4, Q99JS2
      UniProtKB/TrEMBL
      E9Q1D4
      Conserved Domains (1) summary
      pfam15319
      Location:1 → 233
      RHINO; RAD9, RAD1, HUS1-interacting nuclear orphan protein

    5. XM_017321762.3 → XP_017177251.1  RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q3U0N5, Q3UK55, Q8K3A4, Q99JS2
      UniProtKB/TrEMBL
      E9Q1D4
      Related
      ENSMUSP00000152251.2, ENSMUST00000223237.2
      Conserved Domains (1) summary
      pfam15319
      Location:1 → 233
      RHINO; RAD9, RAD1, HUS1-interacting nuclear orphan protein

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_197981.1: Suppressed sequence

      Description
      NM_197981.1: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.

    2. NR_027359.1: Suppressed sequence

      Description
      NR_027359.1: This RefSeq was removed because it is now thought that this gene does encode a protein.

    3. NR_027360.1: Suppressed sequence

      Description
      NR_027360.1: This RefSeq was removed because it is now thought that this gene does encode a protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K3A4.1 GenPept UniProtKB/Swiss-Prot:Q8K3A4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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