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    Cage1 cancer antigen 1 [ Mus musculus (house mouse) ]

    Gene ID: 71213, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cage1provided by MGI
    Official Full Name
    cancer antigen 1provided by MGI
    Primary source
    MGI:MGI:1918463
    See related
    Ensembl:ENSMUSG00000044566 AllianceGenome:MGI:1918463
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ctag3; 4933427I01Rik
    Summary
    Orthologous to human CAGE1 (cancer antigen 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 17.1) and genital fat pad adult (RPKM 0.4) See more
    Orthologs
    human all
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    Genomic context

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    See Cage1 in Genome Data Viewer
    Location:
    13 A3.3; 13 17.88 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (38190028..38221115, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (38006052..38037131, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:37893604-37893840 Neighboring gene ras responsive element binding protein 1 Neighboring gene predicted gene, 46411 Neighboring gene STARR-positive B cell enhancer ABC_E1461 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:37972487-37972670 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:37974410-37974611 Neighboring gene STARR-seq mESC enhancer starr_34234 Neighboring gene STARR-positive B cell enhancer ABC_E11541 Neighboring gene STARR-positive B cell enhancer ABC_E7227 Neighboring gene STARR-positive B cell enhancer ABC_E10789 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:38086110-38086293 Neighboring gene predicted gene, 52041 Neighboring gene signal sequence receptor, alpha Neighboring gene STARR-positive B cell enhancer ABC_E9396 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:38129215-38129324 Neighboring gene RIO kinase 1 Neighboring gene STARR-seq mESC enhancer starr_34240 Neighboring gene STARR-seq mESC enhancer starr_34241 Neighboring gene STARR-positive B cell enhancer ABC_E3077 Neighboring gene desmoplakin Neighboring gene small nuclear ribonucleoprotein 48 (U11/U12)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The cancer/testis antigen CAGE-1 is a component of the acrosome of spermatids and spermatozoa. Alsheimer M, et al. Eur J Cell Biol, 2005 Mar. PMID 15819420
    2. CAGE, a cancer/testis antigen, induces c-FLIP(L) and Snail to enhance cell motility and increase resistance to an anti-cancer drug. Kim Y, et al. Biotechnol Lett, 2009 Jul. PMID 19322522
    3. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CAGE was shown to protect cells against celastrol, an anti-cancer agent.
      Title: CAGE, a cancer/testis antigen, induces c-FLIP(L) and Snail to enhance cell motility and increase resistance to an anti-cancer drug.
    2. novel component of the acrosome of mammalian spermatids and spermatozoa
      Title: The cancer/testis antigen CAGE-1 is a component of the acrosome of spermatids and spermatozoa.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC100323

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    cancer-associated gene 1 protein homolog
    Names
    CAGE-1
    CT3 homolog
    cancer/testis antigen 3 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027724.2 → NP_082000.2  cancer-associated gene 1 protein homolog

      See identical proteins and their annotated locations for NP_082000.2

      Status: VALIDATED

      Source sequence(s)
      AK016953, AY695827, BC082568, BX519141
      Consensus CDS
      CCDS26460.1
      UniProtKB/Swiss-Prot
      A6X913, Q5IR70, Q640N7
      Related
      ENSMUSP00000074499.5, ENSMUST00000074969.11
      Conserved Domains (2) summary
      COG0419
      Location:363 → 812
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam15066
      Location:1 → 526
      CAGE1; Cancer-associated gene protein 1 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      38190028..38221115 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516779.5 → XP_006516842.1  cancer-associated gene 1 protein homolog isoform X4

      Conserved Domains (2) summary
      COG0419
      Location:308 → 748
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam15066
      Location:1 → 526
      CAGE1; Cancer-associated gene protein 1 family

    2. XM_006516776.5 → XP_006516839.1  cancer-associated gene 1 protein homolog isoform X2

      See identical proteins and their annotated locations for XP_006516839.1

      UniProtKB/Swiss-Prot
      A6X913, Q5IR70, Q640N7
      Related
      ENSMUSP00000105862.2, ENSMUST00000110233.8
      Conserved Domains (2) summary
      COG0419
      Location:363 → 812
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      pfam15066
      Location:1 → 526
      CAGE1; Cancer-associated gene protein 1 family

    3. XM_017315602.3 → XP_017171091.1  cancer-associated gene 1 protein homolog isoform X1

      Conserved Domains (2) summary
      TIGR02168
      Location:385 → 691
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15066
      Location:1 → 526
      CAGE1; Cancer-associated gene protein 1 family

    4. XM_036158166.1 → XP_036014059.1  cancer-associated gene 1 protein homolog isoform X8

      Conserved Domains (2) summary
      TIGR02168
      Location:74 → 380
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15066
      Location:1 → 215
      CAGE1; Cancer-associated gene protein 1 family

    5. XM_017315603.3 → XP_017171092.1  cancer-associated gene 1 protein homolog isoform X1

      Conserved Domains (2) summary
      TIGR02168
      Location:385 → 691
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15066
      Location:1 → 526
      CAGE1; Cancer-associated gene protein 1 family

    6. XM_017315604.3 → XP_017171093.1  cancer-associated gene 1 protein homolog isoform X3

      Conserved Domains (2) summary
      TIGR02168
      Location:351 → 657
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15066
      Location:2 → 492
      CAGE1; Cancer-associated gene protein 1 family

    7. XM_030247409.2 → XP_030103269.1  cancer-associated gene 1 protein homolog isoform X7

      Conserved Domains (1) summary
      pfam15066
      Location:1 → 215
      CAGE1; Cancer-associated gene protein 1 family

    8. XM_017315605.3 → XP_017171094.1  cancer-associated gene 1 protein homolog isoform X6

      Conserved Domains (2) summary
      TIGR02168
      Location:279 → 585
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15066
      Location:2 → 420
      CAGE1; Cancer-associated gene protein 1 family

    9. XM_030247408.2 → XP_030103268.1  cancer-associated gene 1 protein homolog isoform X6

      Conserved Domains (2) summary
      TIGR02168
      Location:279 → 585
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15066
      Location:2 → 420
      CAGE1; Cancer-associated gene protein 1 family

    10. XM_030247410.2 → XP_030103270.1  cancer-associated gene 1 protein homolog isoform X7

      Conserved Domains (1) summary
      pfam15066
      Location:1 → 215
      CAGE1; Cancer-associated gene protein 1 family

    11. XM_011244349.4 → XP_011242651.2  cancer-associated gene 1 protein homolog isoform X5

      Conserved Domains (2) summary
      TIGR02168
      Location:385 → 691
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15066
      Location:1 → 526
      CAGE1; Cancer-associated gene protein 1 family

    RNA

    1. XR_003950483.2 RNA Sequence

    2. XR_001780816.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5IR70.2 GenPept UniProtKB/Swiss-Prot:Q5IR70

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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