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    FCRL5 Fc receptor like 5 [ Homo sapiens (human) ]

    Gene ID: 83416, updated on 11-Apr-2024

    Summary

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    Official Symbol
    FCRL5provided by HGNC
    Official Full Name
    Fc receptor like 5provided by HGNC
    Primary source
    HGNC:HGNC:18508
    See related
    Ensembl:ENSG00000143297 MIM:605877; AllianceGenome:HGNC:18508
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD307; FCRH5; IRTA2; BXMAS1; CD307e; PRO820
    Summary
    This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]
    Expression
    Biased expression in lymph node (RPKM 14.3), spleen (RPKM 11.3) and 8 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    1q23.1
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (157513377..157552515, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (156650413..156689576, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (157483167..157522305, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371456 Neighboring gene CRISPRi-validated cis-regulatory element chr1.9249 Neighboring gene SLAM family member 5 Neighboring gene long intergenic non-protein coding RNA 2772 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:157279563-157280762 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1446 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1888 Neighboring gene NANOG hESC enhancer GRCh37_chr1:157391313-157391814 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1889 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1890 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:157489840-157491039 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1891 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1892 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:157556896-157558095 Neighboring gene Fc receptor like 4 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:157593763-157594962 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1447 Neighboring gene uncharacterized LOC105371457

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The rs6427384 and rs6692977 Single Nucleotide Polymorphisms of the Fc Receptor-Like 5 (FCRL5) Gene and the Risk of Ankylosing Spondylitis: A Case Control Study in a Single Center in China. Liu HW, et al. Med Sci Monit, 2020 Sep 6. PMID 32892204, Free PMC Article
    2. Human Fc receptor-like 5 distinguishes IgG2 disulfide isoforms and deamidated charge variants. Alabi O, et al. Mol Immunol, 2017 Dec. PMID 29101848
    3. Fc Receptor-like 5 Expression Distinguishes Two Distinct Subsets of Human Circulating Tissue-like Memory B Cells. Li H, et al. J Immunol, 2016 May 15. PMID 27076679
    4. B cell receptor induced Fc receptor-like 5 expression is mediated by multiple signaling pathways converging on NF-κB and NFAT. Damdinsuren B, et al. Mol Immunol, 2016 May. PMID 27065451
    5. FCRL5 Delineates Functionally Impaired Memory B Cells Associated with Plasmodium falciparum Exposure. Sullivan RT, et al. PLoS Pathog, 2015 May. PMID 25993340, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SARS-CoV-2 spike-specific memory B cells express higher levels of T-bet and FcRL5 after non-severe COVID-19 as compared to severe disease.
      Title: SARS-CoV-2 spike-specific memory B cells express higher levels of T-bet and FcRL5 after non-severe COVID-19 as compared to severe disease.
    2. Fc receptor-like 4 and 5 define human atypical memory B cells.
      Title: Fc receptor-like 4 and 5 define human atypical memory B cells.
    3. The rs6427384 and rs6692977 Single Nucleotide Polymorphisms of the Fc Receptor-Like 5 (FCRL5) Gene and the Risk of Ankylosing Spondylitis: A Case Control Study in a Single Center in China.
      Title: The rs6427384 and rs6692977 Single Nucleotide Polymorphisms of the Fc Receptor-Like 5 (FCRL5) Gene and the Risk of Ankylosing Spondylitis: A Case Control Study in a Single Center in China.
    4. FCRL5 has dual signaling capacity, while CD21 co-engagement serves as molecular switch, converting FCRL5 from a negative to a positive co-receptor; in tissues, B cells that co-express FCRL5 and CD21 could robustly respond to IgG immune complexes loaded with C3 fragments
      Title: CD21 and FCRL5 form a receptor complex with robust B-cell activating capacity.
    5. This study identified novel Single nucleotide polymorphism in FCRL3 and FCRL5 significantly associated with the risk for asthma with comorbid allergic rhinitis in the Chinese population
      Title: Genetic risk of FCRL3 and FCRL5 polymorphisms in children with asthma and allergic rhinitis in a Chinese Han population.
    6. based on FCRL5 binding, we can discern distinct changes in the IgG2 molecule, including the disulfide isoform structure and charge variants related to deamidation. Since both IgG2 deamidation and conversion of disulfide isoforms occur in vivo, these findings elucidate the biological FCRL5 ligand.
      Title: Human Fc receptor-like 5 distinguishes IgG2 disulfide isoforms and deamidated charge variants.
    7. we found that FCRL5 expression is induced specifically upon BCR stimulation and dissected the molecular mechanism
      Title: B cell receptor induced Fc receptor-like 5 expression is mediated by multiple signaling pathways converging on NF-κB and NFAT.
    8. this study revealed that the FCRL5+ tissue-like memory subset responds poorly to multiple stimuli compared with the FCRL5- subset, as reflected by reduced calcium mobilization and blunted cell proliferation
      Title: Fc Receptor-like 5 Expression Distinguishes Two Distinct Subsets of Human Circulating Tissue-like Memory B Cells.
    9. Data suggest that expression of FCRL5 (but not FCRL4) on surface of atypical (perhaps dysfunctional) memory B-Lymphocytes is up-regulated by exposure to Plasmodium falciparum antigens in subjects in Uganda where malaria is endemic.
      Title: FCRL5 Delineates Functionally Impaired Memory B Cells Associated with Plasmodium falciparum Exposure.
    10. FCRL5 is a new type of receptor that recognizes intact IgG, possibly enabling B cells to sense Ig quality. Recognition of undamaged IgG molecules by FCRL5 could allow B cells to engage recently produced Abs.
      Title: Human Fc receptor-like 5 binds intact IgG via mechanisms distinct from those of Fc receptors.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Heritability and genome-wide association analysis of renal sinus fat accumulation in the Framingham Heart Study.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ00333, FLJ00397, MGC119590, MGC119592, MGC119593, DKFZp667F216, DKFZp667E2019

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in single fertilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Fc receptor-like protein 5
    Names
    fc receptor homolog 5
    fcR-like protein 5
    immune receptor translocation-associated protein 2
    immunoglobulin superfamily receptor translocation associated 2 (IRTA2)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027723.1 RefSeqGene

      Range
      5006..44144
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001195388.2 → NP_001182317.1  Fc receptor-like protein 5 isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the 3' coding region, resulting in frame-shift, as compared to variant 1. The resulting isoform (2) has a different and longer C-terminus, as compared to isoform 1.
      Source sequence(s)
      AF369794, AL353899, BC101067, BC101068
      UniProtKB/Swiss-Prot
      Q96RD9
      Conserved Domains (4) summary
      cd05752
      Location:23 → 100
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:577 → 652
      IG_like; Immunoglobulin like
      pfam13895
      Location:105 → 185
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:565 → 638
      Ig_3; Immunoglobulin domain

    2. NM_031281.3 → NP_112571.2  Fc receptor-like protein 5 isoform 1 precursor

      See identical proteins and their annotated locations for NP_112571.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the dominant isoform (1).
      Source sequence(s)
      AF369794, AL353899, BC101067, BE676280
      Consensus CDS
      CCDS1165.1
      UniProtKB/Swiss-Prot
      A0N0M2, B7WNT9, B7WP94, Q495Q2, Q495Q4, Q5VYK9, Q6UY46, Q96RD9
      Related
      ENSP00000354691.3, ENST00000361835.8
      Conserved Domains (4) summary
      cd05752
      Location:23 → 100
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:577 → 652
      IG_like; Immunoglobulin like
      pfam13895
      Location:105 → 185
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:565 → 638
      Ig_3; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      157513377..157552515 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510030.3 → XP_011508332.1  Fc receptor-like protein 5 isoform X1

      Conserved Domains (3) summary
      smart00410
      Location:492 → 567
      IG_like; Immunoglobulin like
      pfam13895
      Location:20 → 100
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:480 → 553
      Ig_3; Immunoglobulin domain

    2. XM_011510032.3 → XP_011508334.1  Fc receptor-like protein 5 isoform X3

      Conserved Domains (4) summary
      cd05752
      Location:23 → 100
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:484 → 559
      IG_like; Immunoglobulin like
      pfam13895
      Location:105 → 185
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:472 → 545
      Ig_3; Immunoglobulin domain

    3. XM_011510031.3 → XP_011508333.1  Fc receptor-like protein 5 isoform X2

      Conserved Domains (4) summary
      cd05752
      Location:23 → 100
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:577 → 652
      IG_like; Immunoglobulin like
      pfam13895
      Location:105 → 185
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:565 → 638
      Ig_3; Immunoglobulin domain

    4. XM_011510033.3 → XP_011508335.1  Fc receptor-like protein 5 isoform X4

      Related
      ENSP00000357173.3, ENST00000368190.7
      Conserved Domains (4) summary
      cd05752
      Location:23 → 100
      Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
      smart00410
      Location:577 → 652
      IG_like; Immunoglobulin like
      pfam13895
      Location:105 → 185
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:565 → 638
      Ig_3; Immunoglobulin domain

    5. XM_047431422.1 → XP_047287378.1  Fc receptor-like protein 5 isoform X5

      Related
      ENSP00000357172.3, ENST00000368189.3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      156650413..156689576 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338960.1 → XP_054194935.1  Fc receptor-like protein 5 isoform X1

    2. XM_054338962.1 → XP_054194937.1  Fc receptor-like protein 5 isoform X3

    3. XM_054338961.1 → XP_054194936.1  Fc receptor-like protein 5 isoform X2

    4. XM_054338963.1 → XP_054194938.1  Fc receptor-like protein 5 isoform X4

    5. XM_054338964.1 → XP_054194939.1  Fc receptor-like protein 5 isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96RD9.3 GenPept UniProtKB/Swiss-Prot:Q96RD9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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