CCNG1 cyclin G1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CCNG1provided by HGNC
Official Full Name: cyclin G1provided by HGNC
Primary source: HGNC:HGNC:1592
See related: Ensembl:ENSG00000113328 MIM:601578; AllianceGenome:HGNC:1592
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CCNG
Summary: The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in duodenum (RPKM 74.2), small intestine (RPKM 61.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q34

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (163437571..163457640)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (163972739..163983375)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (162864577..162875205)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PRMT6 functionally associates with PRMT5 to promote colorectal cancer progression through epigenetically repressing the expression of CDKN2B and CCNG1.
Title: PRMT6 functionally associates with PRMT5 to promote colorectal cancer progression through epigenetically repressing the expression of CDKN2B and CCNG1.
Long noncoding RNA OIP5AS1 facilitates the progression of ovarian cancer via the miR1283p/CCNG1 axis.
Title: Long non‑coding RNA OIP5‑AS1 facilitates the progression of ovarian cancer via the miR‑128‑3p/CCNG1 axis.
Silencing the Expression of Cyclin G1 Enhances the Radiosensitivity of Hepatocellular Carcinoma In Vitro and In Vivo by Inducing Apoptosis.
Title: Silencing the Expression of Cyclin G1 Enhances the Radiosensitivity of Hepatocellular Carcinoma In Vitro and In Vivo by Inducing Apoptosis.
MicroRNA-488 inhibits ovarian cancer cell metastasis through regulating CCNG1 and p53 expression.
Title: MicroRNA-488 inhibits ovarian cancer cell metastasis through regulating CCNG1 and p53 expression.
MicroRNA-23a inhibits the growth of papillary thyroid carcinoma via regulating cyclin G1.
Title: MicroRNA-23a inhibits the growth of papillary thyroid carcinoma via regulating cyclin G1.
Methylation-associated miR-9 down-regulation is probably one of the key mechanisms for paclitaxel resistance in EOC cells, via targeting CCNG1.
Title: Methylation-associated Has-miR-9 deregulation in paclitaxel- resistant epithelial ovarian carcinoma.
Our findings indicate that CCNG1 overexpression, which is associated with poor clinical prognosis of high-grade serous ovarian cancer(HGSOC), can promote metastasis and chemotherapy resistance via the P53mt-Notch3 pathway. Our data also suggest that CCNG1 inhibitors represent a novel approach to increase chemotherapy efficacy in HGSOC and potentially improve patient outcomes.
Title: CCNG1 (Cyclin G1) regulation by mutant-P53 via induction of Notch3 expression promotes high-grade serous ovarian cancer (HGSOC) tumorigenesis and progression.
Cyclin G1 (CG1), an atypical cyclin, promoted G2-M arrest in proximal tubular cell and up-regulated target of rapamycin (TOR)-autophagy spatial coupling compartment formation.
Title: Cyclin G1 and TASCC regulate kidney epithelial cell G(2)-M arrest and fibrotic maladaptive repair.
our findings revealed that the C/EBPbeta-LINC01133 axis performs an oncogenic function in pancreatic ductal adenocarcinoma by activating CCNG1
Title: The C/EBPβ-LINC01133 axis promotes cell proliferation in pancreatic ductal adenocarcinoma through upregulation of CCNG1.
miR-516b functions as a tumor suppressor by directly modulating CCNG1 expression in esophageal squamous carcinoma cells.
Title: miR-516b functions as a tumor suppressor by directly modulating CCNG1 expression in esophageal squamous cell carcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (34)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G20650 (e-PCR)
- UniSTS:61705

A006A21 (e-PCR)
- UniSTS:61706

D8S2279 (e-PCR)
- UniSTS:473907

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in mitotic G2 DNA damage checkpoint signaling	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle phase transition	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity	TAS Traceable Author Statement more info	PubMed
involved_in response to gravity	IEA Inferred from Electronic Annotation more info
involved_in response to organonitrogen compound	IEA Inferred from Electronic Annotation more info
involved_in syncytium formation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cyclin-G1

Names: cyclin-G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001364015.1 → NP_001350944.1 cyclin-G1 isoform a

Status: REVIEWED

Source sequence(s)

AC112205

Consensus CDS

CCDS4360.1

UniProtKB/Swiss-Prot

B2R7B2, B4DLW7, D3DQK7, P51959, Q15757, Q96L32

Conserved Domains (1) summary

cd20583
Location:51 → 148

CYCLIN_CCNG1; cyclin box found in cyclin-G1 (CCNG1) and similar proteins
NM_001364018.1 → NP_001350947.1 cyclin-G1 isoform b

Status: REVIEWED

Source sequence(s)

AC112205

Conserved Domains (1) summary

pfam00134
Location:20 → 149

Cyclin_N; Cyclin, N-terminal domain
NM_001364019.1 → NP_001350948.1 cyclin-G1 isoform c

Status: REVIEWED

Source sequence(s)

AC112205

Conserved Domains (1) summary

pfam00134
Location:20 → 149

Cyclin_N; Cyclin, N-terminal domain
NM_001364020.1 → NP_001350949.1 cyclin-G1 isoform c

Status: REVIEWED

Source sequence(s)

AC112205

Conserved Domains (1) summary

pfam00134
Location:20 → 149

Cyclin_N; Cyclin, N-terminal domain
NM_001364021.1 → NP_001350950.1 cyclin-G1 isoform d

Status: REVIEWED

Source sequence(s)

AC112205

Conserved Domains (1) summary

cl00050
Location:30 → 91

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
NM_001364022.1 → NP_001350951.1 cyclin-G1 isoform e

Status: REVIEWED

Source sequence(s)

AC112205

Consensus CDS

CCDS93817.1

UniProtKB/TrEMBL

E7ERZ1

Related

ENSP00000424315.1, ENST00000512163.5
NM_001364023.1 → NP_001350952.1 cyclin-G1 isoform e

Status: REVIEWED

Source sequence(s)

AC112205

Consensus CDS

CCDS93817.1

UniProtKB/TrEMBL

E7ERZ1
NM_004060.4 → NP_004051.1 cyclin-G1 isoform a

See identical proteins and their annotated locations for NP_004051.1

Status: REVIEWED

Source sequence(s)

BC000196, BX644635

Consensus CDS

CCDS4360.1

UniProtKB/Swiss-Prot

B2R7B2, B4DLW7, D3DQK7, P51959, Q15757, Q96L32

Related

ENSP00000344635.2, ENST00000340828.7

Conserved Domains (1) summary

cd20583
Location:51 → 148

CYCLIN_CCNG1; cyclin box found in cyclin-G1 (CCNG1) and similar proteins
NM_199246.2 → NP_954854.1 cyclin-G1 isoform a

See identical proteins and their annotated locations for NP_954854.1

Status: REVIEWED

Source sequence(s)

BC000196, BM479568

Consensus CDS

CCDS4360.1

UniProtKB/Swiss-Prot

B2R7B2, B4DLW7, D3DQK7, P51959, Q15757, Q96L32

Conserved Domains (1) summary

cd20583
Location:51 → 148

CYCLIN_CCNG1; cyclin box found in cyclin-G1 (CCNG1) and similar proteins

RNA

NR_157051.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC112205, BX538035
NR_157052.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC112205
NR_157053.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC112205
NR_157054.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC112205
NR_157055.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC112205
NR_157056.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC112205