SPDYA speedy/RINGO cell cycle regulator family member A [Homo sapiens (human)] - Gene

Summary

Official Symbol: SPDYAprovided by HGNC
Official Full Name: speedy/RINGO cell cycle regulator family member Aprovided by HGNC
Primary source: HGNC:HGNC:30613
See related: Ensembl:ENSG00000163806 MIM:614029; AllianceGenome:HGNC:30613
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SPY1; SPDY1; RINGO3; RINGOA
Summary: Enables protein kinase activator activity and protein kinase binding activity. Involved in several processes, including G1/S transition of mitotic cell cycle; positive regulation of cell population proliferation; and positive regulation of protein kinase activity. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis (RPKM 22.5), duodenum (RPKM 1.7) and 10 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2p23.2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (28810834..28850610)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (28854444..28894219)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (29033700..29073476)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Salicylidene acylhydrazides attenuate survival of SH-SY5Y neuroblastoma cells through affecting mitotic regulator Speedy/RINGO and ERK/MAPK-PI3K/AKT signaling.
Title: Salicylidene acylhydrazides attenuate survival of SH-SY5Y neuroblastoma cells through affecting mitotic regulator Speedy/RINGO and ERK/MAPK-PI3K/AKT signaling.
The SUN1-SPDYA interaction plays an essential role in meiosis prophase I.
Title: The SUN1-SPDYA interaction plays an essential role in meiosis prophase I.
Speedy/RINGO protein interacts with ERK/MAPK and PI3K/AKT pathways in SH-SY5Y neuroblastoma cells.
Title: Speedy/RINGO protein interacts with ERK/MAPK and PI3K/AKT pathways in SH-SY5Y neuroblastoma cells.
This mouse model demonstrates for the first time that degradation of the cyclin-like protein Spy1 is an essential component of p53-mediated tumour suppression. Targeting cyclin-like protein activity may therefore represent a mechanism of re-sensitizing cells to important cell cycle checkpoints in a therapeutic setting.
Title: The atypical cyclin-like protein Spy1 overrides p53-mediated tumour suppression and promotes susceptibility to breast tumourigenesis.
Authors demonstrate that mammalian Spy1-mediated ERK activation increases ligand-independent phosphorylation and activation of estrogen receptor alpha, correlating with a decrease in tamoxifen sensitivity.
Title: The cyclin-like protein, SPY1, regulates the ERα and ERK1/2 pathways promoting tamoxifen resistance.
The authors find that Spy1 confers structural changes to Cdk2 that obviate the requirement of Cdk activation loop phosphorylation.
Title: Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins.
CRMP1 interacted with Spy1 which would disturb the association of CRMP1 with actin and was involved in the collapse of growth cones induced by Sema3A and regeneration after sciatic nerve crush.
Title: CRMP1 Interacted with Spy1 During the Collapse of Growth Cones Induced by Sema3A and Acted on Regeneration After Sciatic Nerve Crush.
Spy1 participates in the proliferation and apoptosis of epithelial ovarian cancer.
Title: Spy1 participates in the proliferation and apoptosis of epithelial ovarian cancer.
A novel Spy1-CLIPR-59 interplay was identified in glioblastoma resistance to TNF-alpha.
Title: Spy1 induces de-ubiquitinating of RIP1 arrest and confers glioblastoma's resistance to tumor necrosis factor (TNF-α)-induced apoptosis through suppressing the association of CLIPR-59 and CYLD.
Cell adhesion to fibronectin down-regulates the expression of Spy1 and contributes to drug resistance in multiple myeloma cells.
Title: Cell adhesion to fibronectin down-regulates the expression of Spy1 and contributes to drug resistance in multiple myeloma cells.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-112267 (e-PCR)
- UniSTS:168592

WI-15096 (e-PCR)
- UniSTS:77490

D2S1237 (e-PCR)
- UniSTS:148946

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IDA Inferred from Direct Assay more info	PubMed
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in G1/S transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in establishment of protein localization to telomere	IEA Inferred from Electronic Annotation more info
involved_in male meiotic nuclear division	ISS Inferred from Sequence or Structural Similarity more info
involved_in meiotic attachment of telomere to nuclear envelope	IEA Inferred from Electronic Annotation more info
involved_in oogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
involved_in telomere capping	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in XY body	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	IEA Inferred from Electronic Annotation more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: speedy protein A

Names: RINGO A; epididymis secretory sperm binding protein; hSpy/Ringo A; rapid inducer of G2/M progression in oocytes A; speedy homolog A; speedy-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008779.1 → NP_001008779.1 speedy protein A isoform 2

See identical proteins and their annotated locations for NP_001008779.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks some 5' UTR sequence and uses a different splice site in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.

Source sequence(s)

AA625975, AY820303, BC047224

UniProtKB/Swiss-Prot

Q5MJ70

Conserved Domains (1) summary

pfam11357
Location:69 → 199

Spy1; Cell cycle regulatory protein
NM_001142634.2 → NP_001136106.1 speedy protein A isoform 1

See identical proteins and their annotated locations for NP_001136106.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longest transcript. Variants 1 and 3 both encode the longer protein (isoform 1).

Source sequence(s)

AY820304, BC047224, BC093005

Consensus CDS

CCDS1767.2

UniProtKB/Swiss-Prot

Q53R05, Q5MJ69, Q5MJ70

UniProtKB/TrEMBL

A0A384MTT5

Related

ENSP00000368898.4, ENST00000379579.8

Conserved Domains (1) summary

pfam11357
Location:69 → 199

Spy1; Cell cycle regulatory protein
NM_182756.4 → NP_877433.2 speedy protein A isoform 1

See identical proteins and their annotated locations for NP_877433.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) lacks a segment in the 5' UTR, compared to variant 3. Variants 1 and 3 both encode the longer protein (isoform 1).

Source sequence(s)

AY820304, BC047224, BC093005

Consensus CDS

CCDS1767.2

UniProtKB/Swiss-Prot

Q53R05, Q5MJ69, Q5MJ70

UniProtKB/TrEMBL

A0A384MTT5

Related

ENSP00000335628.5, ENST00000334056.10

Conserved Domains (1) summary

pfam11357
Location:69 → 199

Spy1; Cell cycle regulatory protein