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    ZNF275 zinc finger protein 275 [ Homo sapiens (human) ]

    Gene ID: 10838, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZNF275provided by HGNC
    Official Full Name
    zinc finger protein 275provided by HGNC
    Primary source
    HGNC:HGNC:13069
    See related
    Ensembl:ENSG00000063587 AllianceGenome:HGNC:13069
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a zinc finger protein that appears to be conserved in eutheria. Its function has not yet been established. [provided by RefSeq, Jul 2010]
    Expression
    Broad expression in adrenal (RPKM 38.8), ovary (RPKM 27.3) and 24 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    Xq28
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (153334153..153352926)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (151601682..151620455)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (152599611..152618384)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene PWWP domain containing 4 Neighboring gene PNMA family member 6F Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21059 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21060 Neighboring gene Sharpr-MPRA regulatory region 13180 Neighboring gene microRNA 12129 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:152612756-152613256 Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC105373378 Neighboring gene uncharacterized LOC105373379 Neighboring gene PNMA family member 6E Neighboring gene RNA, 7SL, cytoplasmic 667, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21061 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21062 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:152677238-152677448 Neighboring gene ZFP92 zinc finger protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Comparative genome sequence analysis of the Bpa/Str region in mouse and Man. Mallon AM, et al. Genome Res, 2000 Jun. PMID 10854409, Free PMC Article
    2. UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair. Huang Q, et al. FASEB J, 2022 Jan. PMID 34921745
    3. N(6)-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation. Cheng Y, et al. Cancer Cell, 2021 Jul 12. PMID 34048709, Free PMC Article
    4. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. Kumar R, et al. Nat Commun, 2017 Nov 27. PMID 29180619, Free PMC Article
    5. VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Yue Y, et al. Cell Discov, 2018. PMID 29507755, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 275

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021432.2 RefSeqGene

      Range
      4999..23772
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001080485.4 → NP_001073954.3  zinc finger protein 275 isoform 2

      See identical proteins and their annotated locations for NP_001073954.3

      Status: VALIDATED

      Source sequence(s)
      AC152007, AC152008, AK122976
      Consensus CDS
      CCDS48188.2
      UniProtKB/TrEMBL
      A6NFS0
      Related
      ENSP00000359271.2, ENST00000370251.3
      Conserved Domains (5) summary
      COG5048
      Location:207 → 273
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:183 → 203
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:103 → 123
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:295 → 315
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:196 → 219
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001367757.1 → NP_001354686.1  zinc finger protein 275 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC152007, AC152008, BX280482, DA249563, HY052974
      Consensus CDS
      CCDS94693.1
      UniProtKB/Swiss-Prot
      A6NE92, Q9NSD4
      Related
      ENSP00000496975.2, ENST00000650114.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      153334153..153352926
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      151601682..151620455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_020636.2: Suppressed sequence

      Description
      NM_020636.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NSD4.2 GenPept UniProtKB/Swiss-Prot:Q9NSD4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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