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    Dnal1 dynein, axonemal, light chain 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 685664, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Dnal1provided by RGD
    Official Full Name
    dynein, axonemal, light chain 1provided by RGD
    Primary source
    RGD:1591349
    See related
    Ensembl:ENSRNOG00000042333 AllianceGenome:RGD:1591349
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    LC1; Dnalc1
    Summary
    Predicted to enable alpha-tubulin binding activity and dynein heavy chain binding activity. Predicted to be involved in outer dynein arm assembly. Predicted to be located in cell projection and microtubule. Predicted to be part of dynein complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 16. Orthologous to human DNAL1 (dynein axonemal light chain 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 152.7), Lung (RPKM 78.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dnal1 in Genome Data Viewer
    Location:
    6q31
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (109478941..109515201)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (103747801..103779015)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (107596785..107623869)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene acyl-CoA thioesterase 5, pseudogene 1 Neighboring gene uncharacterized LOC134479231 Neighboring gene acyl-CoA thioesterase 6 Neighboring gene uncharacterized LOC120103573 Neighboring gene PNMA family member 1 Neighboring gene mitotic deacetylase associated SANT domain protein Neighboring gene uncharacterized LOC134479232

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Primary ciliary dyskinesia caused by homozygous mutation in DNAL1, encoding dynein light chain 1. Mazor M, et al. Am J Hum Genet, 2011 May 13. PMID 21496787, Free PMC Article
    2. Identification and analysis of axonemal dynein light chain 1 in primary ciliary dyskinesia patients. Horváth J, et al. Am J Respir Cell Mol Biol, 2005 Jul. PMID 15845866
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dynein heavy chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein heavy chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein heavy chain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in outer dynein arm assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in outer dynein arm assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in outer dynein arm assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dynein axonemal light chain 1
    Names
    axonemal dynein light chain 1
    dynein light chain 1, axonemal

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109477.2 → NP_001102947.2  dynein axonemal light chain 1

      Status: VALIDATED

      Source sequence(s)
      BF394767, EV765393
      UniProtKB/Swiss-Prot
      A0A096MJZ0
      UniProtKB/TrEMBL
      A0A8I6AFZ1
      Related
      ENSRNOP00000068314.1, ENSRNOT00000076882.3
      Conserved Domains (3) summary
      COG4886
      Location:37 → 154
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:50 → 71
      LRR_1; leucine-rich repeat [structural motif]
      sd00035
      Location:95 → 116
      LRR_NTF; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      109478941..109515201
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112929.2 → XP_038968857.1  dynein axonemal light chain 1 isoform X3

      UniProtKB/TrEMBL
      A6JDT3
      Conserved Domains (3) summary
      sd00031
      Location:11 → 32
      LRR_1; leucine-rich repeat [structural motif]
      sd00035
      Location:56 → 77
      LRR_NTF; leucine-rich repeat [structural motif]
      cd21340
      Location:5 → 142
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    2. XM_039112928.2 → XP_038968856.1  dynein axonemal light chain 1 isoform X2

      UniProtKB/TrEMBL
      A0A096MJU0, A0A8I6AFZ1
      Related
      ENSRNOP00000068260.2
      Conserved Domains (3) summary
      sd00031
      Location:58 → 78
      LRR_1; leucine-rich repeat [structural motif]
      sd00035
      Location:80 → 124
      LRR_NTF; leucine-rich repeat [structural motif]
      cd21340
      Location:45 → 189
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    3. XM_006240352.5 → XP_006240414.1  dynein axonemal light chain 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AFZ1
      Related
      ENSRNOP00000091622.1
      Conserved Domains (4) summary
      sd00031
      Location:109 → 129
      LRR_1; leucine-rich repeat [structural motif]
      sd00035
      Location:131 → 175
      LRR_NTF; leucine-rich repeat [structural motif]
      pfam12799
      Location:108 → 148
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:129 → 186
      LRR_8; Leucine rich repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A096MJZ0.1 GenPept UniProtKB/Swiss-Prot:A0A096MJZ0

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