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    PDCD2 programmed cell death 2 [ Homo sapiens (human) ]

    Gene ID: 5134, updated on 5-Mar-2024

    Summary

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    Official Symbol
    PDCD2provided by HGNC
    Official Full Name
    programmed cell death 2provided by HGNC
    Primary source
    HGNC:HGNC:8762
    See related
    Ensembl:ENSG00000071994 MIM:600866; AllianceGenome:HGNC:8762
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RP8; ZMYND7
    Summary
    This gene encodes a nuclear protein expressed in a variety of tissues. Expression of this gene has been shown to be repressed by B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on this protein. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 9 and 12. [provided by RefSeq, Dec 2010]
    Expression
    Ubiquitous expression in lymph node (RPKM 7.8), thyroid (RPKM 7.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PDCD2 in Genome Data Viewer
    Location:
    6q27
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (170575295..170584637, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (171948844..171958191, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (170884383..170893725, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25467 Neighboring gene proteasome 20S subunit beta 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25468 Neighboring gene TATA-box binding protein repeat instability region Neighboring gene TATA-box binding protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17802 Neighboring gene uncharacterized LOC101929692 Neighboring gene olfactory receptor family 4 subfamily F member 7 pseudogene Neighboring gene WBP1L pseudogene 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. PDCD2 sensitizes HepG2 cells to sorafenib by suppressing epithelial‑mesenchymal transition. Liu H, et al. Mol Med Rep, 2019 Mar. PMID 30664177, Free PMC Article
    2. Programmed cell death 2 functions as a tumor suppressor in osteosarcoma. Yang Y, et al. Int J Clin Exp Pathol, 2015. PMID 26617804, Free PMC Article
    3. Programmed cell death 2 protein induces gastric cancer cell growth arrest at the early S phase of the cell cycle and apoptosis in a p53-dependent manner. Zhang J, et al. Oncol Rep, 2015 Jan. PMID 25334010
    4. PDCD2 functions in cancer cell proliferation and predicts relapsed leukemia. Barboza N, et al. Cancer Biol Ther, 2013 Jun. PMID 23760497, Free PMC Article
    5. Microbial infections in eight genomic subtypes of chronic fatigue syndrome/myalgic encephalomyelitis. Zhang L, et al. J Clin Pathol, 2010 Feb. PMID 19955554, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PDCD2 functions as an evolutionarily conserved chaperone dedicated for the 40S ribosomal protein uS5 (RPS2).
      Title: PDCD2 functions as an evolutionarily conserved chaperone dedicated for the 40S ribosomal protein uS5 (RPS2).
    2. the present study elucidated for the first time, to the best of our knowledge, that PDCD2 sensitizes sorafenibresistant HepG2 cells to sorafenib by the downregulation of EMT. PDCD2 may serve as a potential therapeutic target in the treatment of sorafenibresistant liver cancer.
      Title: PDCD2 sensitizes HepG2 cells to sorafenib by suppressing epithelial‑mesenchymal transition.
    3. PDCD2 and NCoR1 may act as tumor suppressors in Gastrointestinal stromal tumors cells through the Smad signaling pathway.
      Title: PDCD2 and NCoR1 as putative tumor suppressors in gastric gastrointestinal stromal tumors.
    4. PDCD2 may play an important role in tumor suppression in osteosarcoma. These mechanisms might be related to immune response induced by CD4(+) and CD8(+) T cells.
      Title: Programmed cell death 2 functions as a tumor suppressor in osteosarcoma.
    5. Low PDCD2 expression is associated with gastric cancer.
      Title: miR-129-1-3p promote BGC-823 cell proliferation by targeting PDCD2.
    6. Loss of PDCD2 expression could contribute to gastric cancer development and progression.
      Title: Programmed cell death 2 protein induces gastric cancer cell growth arrest at the early S phase of the cell cycle and apoptosis in a p53-dependent manner.
    7. Expression of human PDCD2 fully rescues the Drosophila Zfrp8 phenotype, underlining the functional conservation of Zfrp8/PDCD2.
      Title: Zfrp8/PDCD2 is required in ovarian stem cells and interacts with the piRNA pathway machinery.
    8. PDCD2 RNA expression in acute leukemia patients correlates with disease status and is a significant predictor of clinical relapse.
      Title: PDCD2 functions in cancer cell proliferation and predicts relapsed leukemia.
    9. PDCD2 has a novel regulatory role in human hematopoiesis and is essential for erythroid development.
      Title: PDCD2 knockdown inhibits erythroid but not megakaryocytic lineage differentiation of human hematopoietic stem/progenitor cells.
    10. Transfection of a construct expressing PDCD2 induces apoptosis in human cell lines through activation of the caspase cascade.
      Title: PDCD2, a protein whose expression is repressed by BCL6, induces apoptosis in human cells by activation of the caspase cascade.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC12347

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of hematopoietic stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    programmed cell death protein 2
    Names
    zinc finger MYND domain-containing protein 7
    zinc finger protein Rp-8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199461.2 → NP_001186390.1  programmed cell death protein 2 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' coding region and UTR, compared to variant 1. The resulting protein (isoform 3) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AJ420535, AL031259, AW966881
      Consensus CDS
      CCDS75557.1
      UniProtKB/TrEMBL
      A0A087WYJ3
      Related
      ENSP00000481860.1, ENST00000614056.4
      Conserved Domains (1) summary
      pfam01753
      Location:135 → 172
      zf-MYND; MYND finger

    2. NM_001199462.2 → NP_001186391.1  programmed cell death protein 2 isoform 4

      See identical proteins and their annotated locations for NP_001186391.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting protein (isoform 4) is shorter, compared to isoform 1.
      Source sequence(s)
      AK055180, AL031259, AY948416, DC351104
      Consensus CDS
      CCDS56461.1
      UniProtKB/Swiss-Prot
      Q16342
      Related
      ENSP00000375940.2, ENST00000392090.6
      Conserved Domains (2) summary
      pfam01753
      Location:102 → 139
      zf-MYND; MYND finger
      pfam04194
      Location:193 → 306
      PDCD2_C; Programmed cell death protein 2, C-terminal putative domain

    3. NM_001199463.2 → NP_001186392.1  programmed cell death protein 2 isoform 5

      See identical proteins and their annotated locations for NP_001186392.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 5' coding region and differs in the 3' coding region and UTR, compared to variant 1. The resulting protein (isoform 5) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AJ420535, AK297343, AL031259
      Consensus CDS
      CCDS56460.1
      UniProtKB/Swiss-Prot
      Q16342
      Related
      ENSP00000397272.2, ENST00000443345.2
      Conserved Domains (1) summary
      pfam01753
      Location:102 → 139
      zf-MYND; MYND finger

    4. NM_001199464.2 → NP_001186393.1  programmed cell death protein 2 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate in-frame splice site in the 5' coding region and differs in the 3' coding region and UTR, compared to variant 1. The resulting protein (isoform 6) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AJ420535, AK297343, AL031259, BX385363
      Consensus CDS
      CCDS56462.1
      UniProtKB/Swiss-Prot
      Q16342
      Related
      ENSP00000440572.1, ENST00000537445.5
      Conserved Domains (1) summary
      pfam01753
      Location:102 → 139
      zf-MYND; MYND finger

    5. NM_001363655.2 → NP_001350584.1  programmed cell death protein 2 isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (7) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL031259
      Consensus CDS
      CCDS87471.1
      UniProtKB/TrEMBL
      F5H4V9
      Related
      ENSP00000439914.1, ENST00000542896.5
      Conserved Domains (2) summary
      pfam01753
      Location:135 → 172
      zf-MYND; MYND finger
      pfam04194
      Location:226 → 292
      PDCD2_C; Programmed cell death protein 2, C-terminal putative domain

    6. NM_002598.4 → NP_002589.2  programmed cell death protein 2 isoform 1

      See identical proteins and their annotated locations for NP_002589.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK055180, AL031259, BC008378
      Consensus CDS
      CCDS5316.1
      UniProtKB/Swiss-Prot
      E9PCU7, F5GYS7, Q16342, Q58HM9, Q58HN0, Q9UH12
      Related
      ENSP00000439467.1, ENST00000541970.6
      Conserved Domains (2) summary
      pfam01753
      Location:135 → 172
      zf-MYND; MYND finger
      pfam04194
      Location:226 → 339
      PDCD2_C; Programmed cell death protein 2, C-terminal putative domain

    7. NM_144781.3 → NP_659005.1  programmed cell death protein 2 isoform 2

      See identical proteins and their annotated locations for NP_659005.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and UTR, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AJ420535, AL031259
      Consensus CDS
      CCDS47521.1
      UniProtKB/Swiss-Prot
      Q16342
      Related
      ENSP00000402524.2, ENST00000453163.6
      Conserved Domains (1) summary
      pfam01753
      Location:135 → 172
      zf-MYND; MYND finger

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      170575295..170584637 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047418861.1 → XP_047274817.1  programmed cell death protein 2 isoform X1

      UniProtKB/TrEMBL
      J3QK82
      Related
      ENSP00000167218.5, ENST00000167218.9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      171948844..171958191 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054355579.1 → XP_054211554.1  programmed cell death protein 2 isoform X1

      UniProtKB/TrEMBL
      J3QK82
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q16342.2 GenPept UniProtKB/Swiss-Prot:Q16342

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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