Klhl41 kelch-like family member 41 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Klhl41provided by RGD
Official Full Name: kelch-like family member 41provided by RGD
Primary source: RGD:620852
See related: Ensembl:ENSRNOG00000007461 AllianceGenome:RGD:620852
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Krp1; Kbtbd10; Sarcosin
Summary: Predicted to be involved in several processes, including regulation of myoblast differentiation; regulation of myoblast proliferation; and skeletal muscle cell differentiation. Located in cytoplasm and pseudopodium. Human ortholog(s) of this gene implicated in nemaline myopathy 9. Orthologous to human KLHL41 (kelch like family member 41). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 2351.3) and Heart (RPKM 314.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 3q21

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (74842118..74855244)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (54434291..54447415)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (55910177..55923303)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that both knockdown and overexpression of Krp1 inhibit myoblast differentiation assessed by expression of myogenin, MEF2C, MHC, and cell fusion.
Title: BTB-Kelch protein Krp1 regulates proliferation and differentiation of myoblasts.
binding sites necessary for Krp1-Lasp1 interaction in vitro and function in vivo.
Title: Novel beta-propeller of the BTB-Kelch protein Krp1 provides a binding site for Lasp-1 that is necessary for pseudopodial extension.
Krp1, the AP-1 up-regulated protein that has a role in pseudopodial elongation in v-Fos-transformed fibroblast cells, forms a novel interaction with the nondifferentially expressed actin binding protein Lasp-1.
Title: AP-1 differentially expressed proteins Krp1 and fibronectin cooperatively enhance Rho-ROCK-independent mesenchymal invasion by altering the function, localization, and activity of nondifferentially expressed proteins.

Submit: New GeneRIF Correction

General gene information

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Markers

fd52b08.x1 (e-PCR)
- UniSTS:195620

RH132483 (e-PCR)
- UniSTS:215766

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in myofibril assembly	ISO Inferred from Sequence Orthology more info
involved_in myofibril assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in pseudopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of myoblast differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of myoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of myoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of myoblast proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of myoblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of myoblast proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of skeletal muscle cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of skeletal muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle cell differentiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
is_active_in M band	IBA Inferred from Biological aspect of Ancestor more info
located_in M band	ISO Inferred from Sequence Orthology more info
located_in M band	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in pseudopodium	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle	IEA Inferred from Electronic Annotation more info
is_active_in sarcoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: kelch-like protein 41

Names: kel-like protein 23; kelch repeat and BTB (POZ) domain containing 10; kelch repeat and BTB domain-containing protein 10; kelch-like 41; kelch-related protein 1; sarcomeric muscle protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_057191.2 → NP_476539.1 kelch-like protein 41

See identical proteins and their annotated locations for NP_476539.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q9ER30

UniProtKB/TrEMBL

A6HM09

Related

ENSRNOP00000009969.2, ENSRNOT00000009969.4

Conserved Domains (7) summary

smart00612
Location:346 → 398

Kelch; Kelch domain

PHA03098
Location:39 → 578

PHA03098; kelch-like protein; Provisional

sd00038
Location:388 → 433

Kelch; KELCH repeat [structural motif]

pfam00651
Location:23 → 127

BTB; BTB/POZ domain

pfam01344
Location:484 → 529

Kelch_1; Kelch motif

pfam07707
Location:147 → 237

BACK; BTB And C-terminal Kelch

pfam13964
Location:439 → 485

Kelch_6; Kelch motif