Trpc5 transient receptor potential cation channel, subfamily C, member 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trpc5provided by RGD
Official Full Name: transient receptor potential cation channel, subfamily C, member 5provided by RGD
Primary source: RGD:619787
See related: Ensembl:ENSRNOG00000027233 AllianceGenome:RGD:619787
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Trrp5
Summary: Enables ATPase binding activity; clathrin binding activity; and cytoskeletal protein binding activity. Involved in several processes, including generation of neurons; positive regulation of peptidyl-threonine phosphorylation; and regulation of membrane hyperpolarization. Located in several cellular components, including growth cone; membrane raft; and neuronal cell body. Orthologous to human TRPC5 (transient receptor potential cation channel subfamily C member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 53.1), Adrenal (RPKM 11.3) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq34

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (112742828..113027638, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (107946163..108230991, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (115624670..115908248, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRPC5 channel participates in myocardial injury in chronic intermittent hypoxia.
Title: TRPC5 channel participates in myocardial injury in chronic intermittent hypoxia.
Transient receptor potential canonical 5 channel is involved in the cardiac damage related to obstructive sleep apnea-hypopnea syndrome in rats.
Title: Transient receptor potential canonical 5 channel is involved in the cardiac damage related to obstructive sleep apnea-hypopnea syndrome in rats.
Specific Upregulation of TRPC1 and TRPC5 Channels by Mineralocorticoid Pathway in Adult Rat Ventricular Cardiomyocytes.
Title: Specific Upregulation of TRPC1 and TRPC5 Channels by Mineralocorticoid Pathway in Adult Rat Ventricular Cardiomyocytes.
TRPC5 channels represent a key pressure transducer in the baroreceptors and play an important role in maintaining blood pressure stability.
Title: TRPC5 channels participate in pressure-sensing in aortic baroreceptors.
Aldosterone specifically increased the mRNA and/or protein levels of Orai1, TRPC1, -C4, -C5, and stromal interaction molecule 1 through mineralocorticoid receptor activation
Title: Transient Receptor Potential Canonical (TRPC)/Orai1-dependent Store-operated Ca2+ Channels: NEW TARGETS OF ALDOSTERONE IN CARDIOMYOCYTES.
there is an association between expressions of TRPC3/5 and cognitive changes in CUS rat model; mechanism may be that the different expressions of TRPC3/5 can cause morphological changes of the neurons in hippocampus
Title: The possible relationship between expressions of TRPC3/5 channels and cognitive changes in rat model of chronic unpredictable stress.
the S4-S5 linker is a critical constituent of TRPC4/C5 channel gating and that disturbance of its sequence allows channel opening independent of any sensor domain.
Title: Conserved gating elements in TRPC4 and TRPC5 channels.
TRPC5 acts as a novel and specific mediator for neurotrophin (NT)-3 to regulate dendrite development through calcium/calmodulin-dependent protein kinase (CaMK)IIalpha.
Title: TRPC5 channel is the mediator of neurotrophin-3 in regulating dendritic growth via CaMKIIα in rat hippocampal neurons.
insertion of TRPC5 channels contributes to the generation of the prolonged afterdepolarizations following muscarinic stimulation.
Title: Plasma membrane insertion of TRPC5 channels contributes to the cholinergic plateau potential in hippocampal CA1 pyramidal neurons.
Cholecystokinin-induced enhancement of neuronal excitability is inhibited significantly by intracellular application of Trpc5 antibody.
Title: Cholecystokinin facilitates neuronal excitability in the entorhinal cortex via activation of TRPC-like channels.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables actinin binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium channel activity	ISO Inferred from Sequence Orthology more info
enables clathrin binding	IDA Inferred from Direct Assay more info	PubMed
enables inositol 1,4,5 trisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables inositol 1,4,5 trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables store-operated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in phosphatidylserine exposure on apoptotic cell surface	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-threonine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of membrane hyperpolarization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of calcium channel complex	ISO Inferred from Sequence Orthology more info
part_of cation channel complex	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: short transient receptor potential channel 5

Names: transient receptor protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080898.3 → NP_543174.1 short transient receptor potential channel 5

See identical proteins and their annotated locations for NP_543174.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A0A0G2K149, A6KG95, A6ZIF3, F1M176, Q8VD38

Related

ENSRNOP00000009400.7, ENSRNOT00000009400.7

Conserved Domains (2) summary

TIGR00870
Location:17 → 756

trp; transient-receptor-potential calcium channel protein

sd00045
Location:69 → 98

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

112742828..113027638 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063279766.1 → XP_063135836.1 short transient receptor potential channel 5 isoform X1

UniProtKB/TrEMBL

A0A0G2K149, A6KG95, A6ZIF3, F1M176, Q8VD38
XM_063279765.1 → XP_063135835.1 short transient receptor potential channel 5 isoform X1

UniProtKB/TrEMBL

A0A0G2K149, A6KG95, A6ZIF3, F1M176, Q8VD38
XM_063279767.1 → XP_063135837.1 short transient receptor potential channel 5 isoform X2