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    Epb41l3 erythrocyte membrane protein band 4.1-like 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116724, updated on 2-May-2024

    Summary

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    Official Symbol
    Epb41l3provided by RGD
    Official Full Name
    erythrocyte membrane protein band 4.1-like 3provided by RGD
    Primary source
    RGD:71089
    See related
    Ensembl:ENSRNOG00000016724 AllianceGenome:RGD:71089
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Epb4.1l3; Kiaa0987
    Summary
    Predicted to enable actin binding activity and structural molecule activity. Predicted to be involved in several processes, including nervous system development; paranodal junction maintenance; and protein localization to paranode region of axon. Located in paranode region of axon. Orthologous to human EPB41L3 (erythrocyte membrane protein band 4.1 like 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 162.7), Kidney (RPKM 118.9) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Epb41l3 in Genome Data Viewer
    Location:
    9q38
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (116502864..116707274)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (109056178..109260607)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (117314935..117666408)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L24, pseudogene 2 Neighboring gene uncharacterized LOC134480430 Neighboring gene zinc finger and BTB domain containing 14 Neighboring gene uncharacterized LOC134480431 Neighboring gene A-kinase anchor inhibitor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Evidence for protein 4.1B acting as a metastasis suppressor. Cavanna T, et al. J Cell Sci, 2007 Feb 15. PMID 17264155
    2. Type II brain 4.1 (4.1B/KIAA0987), a member of the protein 4.1 family, is localized to neuronal paranodes. Ohara R, et al. Brain Res Mol Brain Res, 2000 Dec 28. PMID 11146105
    3. Expression and DNA methylation patterns of Tslc1 and Dal-1 genes in hepatocellular carcinomas induced by N-nitrosodiethylamine in rats. Tsujiuchi T, et al. Cancer Sci, 2007 Jul. PMID 17428255
    4. Loss of DAL-1, a protein 4.1-related tumor suppressor, is an important early event in the pathogenesis of meningiomas. Gutmann DH, et al. Hum Mol Genet, 2000 Jun 12. PMID 10888600
    5. Comparison of mRNA and protein levels of four members of the protein 4.1 family: the type II brain 4.1/4.1B/KIAA0987 is the most predominant member of the protein 4.1 family in rat brain. Yamakawa H, et al. Gene, 2000 May 2. PMID 10806359

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axon development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cortical actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in myelin maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron projection morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in paranodal junction assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in paranodal junction maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to juxtaparanode region of axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to paranode region of axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axolemma ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in juxtaparanode region of axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in paranode region of axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in paranode region of axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    band 4.1-like protein 3
    Names
    erythrocyte protein band 4.1-like 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395722.1 → NP_001382651.1  band 4.1-like protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6AUN0, A3E0T0
      Conserved Domains (5) summary
      smart00295
      Location:115 → 304
      B41; Band 4.1 homologues
      cd13184
      Location:299 → 392
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:540 → 587
      SAB; SAB domain
      pfam05902
      Location:757 → 862
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:401 → 444
      FA; FERM adjacent (FA)

    2. NM_001395723.1 → NP_001382652.1  band 4.1-like protein 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6AUN0
      Conserved Domains (4) summary
      smart00295
      Location:115 → 304
      B41; Band 4.1 homologues
      cd13184
      Location:299 → 392
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam05902
      Location:675 → 753
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:401 → 444
      FA; FERM adjacent (FA)

    3. NM_001395724.1 → NP_001382653.1  band 4.1-like protein 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6AUN0
      Conserved Domains (2) summary
      smart00295
      Location:115 → 304
      B41; Band 4.1 homologues
      cd13184
      Location:299 → 392
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family

    4. NM_053927.2 → NP_446379.1  band 4.1-like protein 3 isoform 1

      See identical proteins and their annotated locations for NP_446379.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I5ZSB9, A6KF70, F7EZF8, Q9JMB3
      Related
      ENSRNOP00000022849.3, ENSRNOT00000022849.6
      Conserved Domains (5) summary
      smart00295
      Location:115 → 304
      B41; Band 4.1 homologues
      cd13184
      Location:299 → 392
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:733 → 781
      SAB; SAB domain
      pfam05902
      Location:992 → 1097
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:401 → 444
      FA; FERM adjacent (FA)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      116502864..116707274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063266554.1 → XP_063122624.1  band 4.1-like protein 3 isoform X15

    2. XM_063266552.1 → XP_063122622.1  band 4.1-like protein 3 isoform X10

    3. XM_063266563.1 → XP_063122633.1  band 4.1-like protein 3 isoform X26

    4. XM_063266546.1 → XP_063122616.1  band 4.1-like protein 3 isoform X3

    5. XM_063266550.1 → XP_063122620.1  band 4.1-like protein 3 isoform X8

    6. XM_039082927.2 → XP_038938855.2  band 4.1-like protein 3 isoform X1

    7. XM_063266555.1 → XP_063122625.1  band 4.1-like protein 3 isoform X16

    8. XM_063266545.1 → XP_063122615.1  band 4.1-like protein 3 isoform X2

    9. XM_063266549.1 → XP_063122619.1  band 4.1-like protein 3 isoform X7

    10. XM_039082928.2 → XP_038938856.2  band 4.1-like protein 3 isoform X6

    11. XM_039082931.2 → XP_038938859.2  band 4.1-like protein 3 isoform X14

    12. XM_063266548.1 → XP_063122618.1  band 4.1-like protein 3 isoform X5

    13. XM_039082933.2 → XP_038938861.2  band 4.1-like protein 3 isoform X17

    14. XM_039082929.2 → XP_038938857.2  band 4.1-like protein 3 isoform X11

    15. XM_017596242.3 → XP_017451731.2  band 4.1-like protein 3 isoform X13

    16. XM_039082930.2 → XP_038938858.2  band 4.1-like protein 3 isoform X12

    17. XM_063266558.1 → XP_063122628.1  band 4.1-like protein 3 isoform X20

    18. XM_063266562.1 → XP_063122632.1  band 4.1-like protein 3 isoform X25

    19. XM_063266556.1 → XP_063122626.1  band 4.1-like protein 3 isoform X18

    20. XM_063266557.1 → XP_063122627.1  band 4.1-like protein 3 isoform X19

    21. XM_039082934.2 → XP_038938862.2  band 4.1-like protein 3 isoform X23

    22. XM_063266560.1 → XP_063122630.1  band 4.1-like protein 3 isoform X22

    23. XM_063266569.1 → XP_063122639.1  band 4.1-like protein 3 isoform X40

    24. XM_063266559.1 → XP_063122629.1  band 4.1-like protein 3 isoform X21

    25. XM_039082941.2 → XP_038938869.1  band 4.1-like protein 3 isoform X37

      UniProtKB/TrEMBL
      A0A8I6AUN0
      Conserved Domains (5) summary
      smart00295
      Location:115 → 304
      B41; Band 4.1 homologues
      cd13184
      Location:299 → 392
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:522 → 569
      SAB; SAB domain
      pfam05902
      Location:739 → 844
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:401 → 444
      FA; FERM adjacent (FA)

    26. XM_063266568.1 → XP_063122638.1  band 4.1-like protein 3 isoform X38

    27. XM_063266564.1 → XP_063122634.1  band 4.1-like protein 3 isoform X30

    28. XM_017596246.3 → XP_017451735.1  band 4.1-like protein 3 isoform X33

      UniProtKB/TrEMBL
      A0A8I6AUN0, A3E0T0
      Conserved Domains (5) summary
      smart00295
      Location:115 → 304
      B41; Band 4.1 homologues
      cd13184
      Location:299 → 392
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:540 → 587
      SAB; SAB domain
      pfam05902
      Location:757 → 862
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:401 → 444
      FA; FERM adjacent (FA)

    29. XM_039082943.2 → XP_038938871.1  band 4.1-like protein 3 isoform X39

      UniProtKB/TrEMBL
      A0A8I5ZZJ7, A0A8I6AUN0
      Related
      ENSRNOP00000083215.1
      Conserved Domains (5) summary
      smart00295
      Location:115 → 304
      B41; Band 4.1 homologues
      cd13184
      Location:299 → 392
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:540 → 587
      SAB; SAB domain
      pfam05902
      Location:757 → 835
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:401 → 444
      FA; FERM adjacent (FA)

    30. XM_063266565.1 → XP_063122635.1  band 4.1-like protein 3 isoform X34

    31. XM_039082939.2 → XP_038938867.1  band 4.1-like protein 3 isoform X36

      UniProtKB/TrEMBL
      A0A0G2K1Q9
      Conserved Domains (5) summary
      smart00295
      Location:115 → 304
      B41; Band 4.1 homologues
      cd13184
      Location:299 → 392
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:533 → 581
      SAB; SAB domain
      pfam05902
      Location:751 → 856
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:401 → 444
      FA; FERM adjacent (FA)

    32. XM_039082937.2 → XP_038938865.1  band 4.1-like protein 3 isoform X31

      UniProtKB/TrEMBL
      A0A8I6AUN0
      Conserved Domains (5) summary
      smart00295
      Location:115 → 304
      B41; Band 4.1 homologues
      cd13184
      Location:299 → 392
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:522 → 569
      SAB; SAB domain
      pfam05902
      Location:780 → 885
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:401 → 444
      FA; FERM adjacent (FA)

    33. XM_063266573.1 → XP_063122643.1  band 4.1-like protein 3 isoform X44

    34. XM_017596244.3 → XP_017451733.1  band 4.1-like protein 3 isoform X27

      UniProtKB/TrEMBL
      A0A0G2K1Q9, A6KF71
      Related
      ENSRNOP00000071945.2
      Conserved Domains (7) summary
      smart00295
      Location:115 → 304
      B41; Band 4.1 homologues
      cd13184
      Location:299 → 392
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:199 → 304
      FERM_M; FERM central domain
      pfam04382
      Location:551 → 597
      SAB; SAB domain
      pfam05902
      Location:810 → 915
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:401 → 441
      FA; FERM adjacent (FA)
      pfam09379
      Location:117 → 180
      FERM_N; FERM N-terminal domain

    35. XM_039082938.2 → XP_038938866.1  band 4.1-like protein 3 isoform X32

      UniProtKB/TrEMBL
      A0A0G2K1Q9
      Conserved Domains (5) summary
      smart00295
      Location:115 → 304
      B41; Band 4.1 homologues
      cd13184
      Location:299 → 392
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:551 → 599
      SAB; SAB domain
      pfam05902
      Location:769 → 874
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:401 → 444
      FA; FERM adjacent (FA)

    36. XM_039082936.2 → XP_038938864.1  band 4.1-like protein 3 isoform X28

      UniProtKB/TrEMBL
      A0A8I6AUN0, F7FPP7
      Related
      ENSRNOP00000040775.3
      Conserved Domains (5) summary
      smart00295
      Location:115 → 304
      B41; Band 4.1 homologues
      cd13184
      Location:299 → 392
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam04382
      Location:540 → 587
      SAB; SAB domain
      pfam05902
      Location:798 → 903
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:401 → 444
      FA; FERM adjacent (FA)

    37. XM_017596247.3 → XP_017451736.1  band 4.1-like protein 3 isoform X42

      UniProtKB/TrEMBL
      A0A8I6AUN0
      Conserved Domains (6) summary
      smart00295
      Location:115 → 304
      B41; Band 4.1 homologues
      cd13184
      Location:299 → 392
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:199 → 304
      FERM_M; FERM central domain
      pfam05902
      Location:675 → 780
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:401 → 441
      FA; FERM adjacent (FA)
      pfam09379
      Location:117 → 180
      FERM_N; FERM N-terminal domain

    38. XM_063266572.1 → XP_063122642.1  band 4.1-like protein 3 isoform X43

    39. XM_017596245.3 → XP_017451734.1  band 4.1-like protein 3 isoform X29

      UniProtKB/TrEMBL
      A0A0G2K1Q9
      Conserved Domains (7) summary
      smart00295
      Location:115 → 304
      B41; Band 4.1 homologues
      cd13184
      Location:299 → 392
      FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
      pfam00373
      Location:199 → 304
      FERM_M; FERM central domain
      pfam04382
      Location:533 → 579
      SAB; SAB domain
      pfam05902
      Location:792 → 897
      4_1_CTD; 4.1 protein C-terminal domain (CTD)
      pfam08736
      Location:401 → 441
      FA; FERM adjacent (FA)
      pfam09379
      Location:117 → 180
      FERM_N; FERM N-terminal domain

    40. XM_063266551.1 → XP_063122621.1  band 4.1-like protein 3 isoform X9

    41. XM_063266547.1 → XP_063122617.1  band 4.1-like protein 3 isoform X4

    42. XM_063266571.1 → XP_063122641.1  band 4.1-like protein 3 isoform X41

      UniProtKB/TrEMBL
      A6KF69

    43. XM_063266561.1 → XP_063122631.1  band 4.1-like protein 3 isoform X24

    44. XM_063266570.1 → XP_063122640.1  band 4.1-like protein 3 isoform X39

      UniProtKB/TrEMBL
      A0A8I5ZZJ7

    45. XM_063266567.1 → XP_063122637.1  band 4.1-like protein 3 isoform X34

    46. XM_063266566.1 → XP_063122636.1  band 4.1-like protein 3 isoform X35

      UniProtKB/TrEMBL
      A0A8I5ZVK0
    Nucleotide Protein Strain
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