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    Aatk apoptosis-associated tyrosine kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 690853, updated on 25-Apr-2024

    Summary

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    Official Symbol
    Aatkprovided by RGD
    Official Full Name
    apoptosis-associated tyrosine kinaseprovided by RGD
    Primary source
    RGD:1590980
    See related
    Ensembl:ENSRNOG00000004392 AllianceGenome:RGD:1590980
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein tyrosine kinase activity. Predicted to be involved in brain development and peptidyl-tyrosine autophosphorylation. Predicted to act upstream of or within several processes, including Rab protein signal transduction; negative regulation of axon extension; and protein autophosphorylation. Predicted to be located in several cellular components, including axonal growth cone; perinuclear region of cytoplasm; and recycling endosome. Orthologous to human AATK (apoptosis associated tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 98.1), Adrenal (RPKM 23.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Aatk in Genome Data Viewer
    Location:
    10q32.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (105789171..105825634, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (105290752..105327219, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (109184338..109224455, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene charged multivesicular body protein 6 Neighboring gene uncharacterized LOC102555825 Neighboring gene BAR/IMD domain containing adaptor protein 2 Neighboring gene microRNA 3065 Neighboring gene microRNA 338 Neighboring gene microRNA 3594 Neighboring gene centrosomal protein 131 Neighboring gene microRNA 3562

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A potential regulatory role for intronic microRNA-338-3p for its host gene encoding apoptosis-associated tyrosine kinase. Kos A, et al. PLoS One, 2012. PMID 22363537, Free PMC Article
    2. AATYK: a novel tyrosine kinase induced during growth arrest and apoptosis of myeloid cells. Gaozza E, et al. Oncogene, 1997 Dec 18. PMID 9444961
    3. Palmitoylation-dependent endosomal localization of AATYK1A and its interaction with Src. Tsutsumi K, et al. Genes Cells, 2008 Sep. PMID 18691334
    4. Characterization of the apoptosis-associated tyrosine kinase (AATYK) expressed in the CNS. Tomomura M, et al. Oncogene, 2001 Mar 1. PMID 11314040
    5. Structural and functional analysis of the apoptosis-associated tyrosine kinase (AATYK) family. Tomomura M, et al. Neuroscience, 2007 Aug 24. PMID 17651901

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-338-3p participates in the regulation of its host gene by modulating the levels of AATK mRNA.
      Title: A potential regulatory role for intronic microRNA-338-3p for its host gene encoding apoptosis-associated tyrosine kinase.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in brain development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within brain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-tyrosine autophosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase LMTK1
    NP_001381515.1
    XP_006247989.1
    XP_038942816.1
    XP_063125958.1
    XP_063125959.1
    XP_063125960.1
    XP_063125961.1
    XP_063125962.1
    XP_063125963.1
    XP_063125964.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394586.1 → NP_001381515.1  serine/threonine-protein kinase LMTK1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HLA5, D4ABZ3
      Related
      ENSRNOP00000005839.5, ENSRNOT00000005839.6
      Conserved Domains (2) summary
      PHA03247
      Location:715 → 1138
      PHA03247; large tegument protein UL36; Provisional
      cd05087
      Location:137 → 407
      PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1

    RNA

    1. NR_172137.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      105789171..105825634 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269888.1 → XP_063125958.1  serine/threonine-protein kinase LMTK1 isoform X1

    2. XM_063269893.1 → XP_063125963.1  serine/threonine-protein kinase LMTK1 isoform X5

    3. XM_063269890.1 → XP_063125960.1  serine/threonine-protein kinase LMTK1 isoform X4

    4. XM_063269892.1 → XP_063125962.1  serine/threonine-protein kinase LMTK1 isoform X4

    5. XM_063269894.1 → XP_063125964.1  serine/threonine-protein kinase LMTK1 isoform X5

    6. XM_063269891.1 → XP_063125961.1  serine/threonine-protein kinase LMTK1 isoform X4

    7. XM_063269889.1 → XP_063125959.1  serine/threonine-protein kinase LMTK1 isoform X2

    8. XM_006247927.5 → XP_006247989.1  serine/threonine-protein kinase LMTK1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AUM9, A6HLA5
      Related
      ENSRNOP00000097193.1
      Conserved Domains (2) summary
      smart00221
      Location:89 → 356
      STYKc; Protein kinase; unclassified specificity
      cd05087
      Location:88 → 358
      PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1

    9. XM_039086888.2 → XP_038942816.1  serine/threonine-protein kinase LMTK1 isoform X6

      Conserved Domains (3) summary
      PHA03247
      Location:640 → 865
      PHA03247; large tegument protein UL36; Provisional
      cd05087
      Location:137 → 407
      PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1
      pfam05109
      Location:769 → 932
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    Nucleotide Protein Strain
    Heading Accession and Version

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