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    Adamts10 ADAM metallopeptidase with thrombospondin type 1 motif, 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314655, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Adamts10provided by RGD
    Official Full Name
    ADAM metallopeptidase with thrombospondin type 1 motif, 10provided by RGD
    Primary source
    RGD:1598320
    See related
    Ensembl:ENSRNOG00000008857 AllianceGenome:RGD:1598320
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable metal ion binding activity and metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in collagen-containing extracellular matrix and microfibril. Human ortholog(s) of this gene implicated in Weill-Marchesani syndrome. Orthologous to human ADAMTS10 (ADAM metallopeptidase with thrombospondin type 1 motif 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 345.4), Spleen (RPKM 133.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adamts10 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (15033859..15063800)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (14331659..14361620)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (18409147..18439012)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene NudC domain containing 2, pseudogene 1 Neighboring gene uncharacterized LOC102549242 Neighboring gene uncharacterized LOC120093540 Neighboring gene myosin IF Neighboring gene BAF nuclear assembly factor 1, pseudogene 1 Neighboring gene zinc finger protein 414

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Optic neuropathy associated with TGFβ dysregulation in mice with a glaucoma-causative mutation of ADAMTS10. Wu HJ, et al. Matrix Biol, 2022 Nov. PMID 36216203, Free PMC Article
    2. Altered Ocular Fibrillin Microfibril Composition in Mice With a Glaucoma-Causing Mutation of Adamts10. Wu HJ, et al. Invest Ophthalmol Vis Sci, 2021 Aug 2. PMID 34424262, Free PMC Article
    3. ADAMTS10 protein interacts with fibrillin-1 and promotes its deposition in extracellular matrix of cultured fibroblasts. Kutz WE, et al. J Biol Chem, 2011 May 13. PMID 21402694, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124747

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microfibril ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    A disintegrin and metalloproteinase with thrombospondin motifs 10
    Names
    a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 10
    a disintegrin-like and metalloprotease with thrombospondin type 1 motif, 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271445.1 → NP_001258374.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2K229
      Related
      ENSRNOP00000072082.1, ENSRNOT00000086336.2
      Conserved Domains (7) summary
      smart00209
      Location:550 → 602
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:239 → 454
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam05986
      Location:706 → 818
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam01562
      Location:40 → 180
      Pep_M12B_propep; Reprolysin family propeptide
      pfam08686
      Location:1070 → 1102
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:469 → 537
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:948 → 1002
      TSP1_ADAMTS; Thrombospondin type 1 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      15033859..15063800
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079031.2 → XP_038934959.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K229
      Conserved Domains (7) summary
      smart00209
      Location:550 → 602
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:239 → 454
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam05986
      Location:706 → 818
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam01562
      Location:40 → 180
      Pep_M12B_propep; Reprolysin family propeptide
      pfam08686
      Location:1070 → 1102
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:469 → 537
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:948 → 1002
      TSP1_ADAMTS; Thrombospondin type 1 domain

    2. XM_039079032.2 → XP_038934960.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X2

      Conserved Domains (7) summary
      smart00209
      Location:484 → 536
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:173 → 388
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam05986
      Location:640 → 752
      ADAM_spacer1; ADAM-TS Spacer 1
      pfam01562
      Location:80 → 114
      Pep_M12B_propep; Reprolysin family propeptide
      pfam08686
      Location:1004 → 1036
      PLAC; PLAC (protease and lacunin) domain
      pfam17771
      Location:403 → 471
      ADAM_CR_2; ADAM cysteine-rich domain
      pfam19030
      Location:882 → 936
      TSP1_ADAMTS; Thrombospondin type 1 domain

    3. XM_063263434.1 → XP_063119504.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X3

    4. XM_039079033.2 → XP_038934961.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X4

      Conserved Domains (4) summary
      smart00209
      Location:550 → 602
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:239 → 454
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam01562
      Location:40 → 180
      Pep_M12B_propep; Reprolysin family propeptide
      pfam17771
      Location:469 → 537
      ADAM_CR_2; ADAM cysteine-rich domain

    5. XM_017594822.2 → XP_017450311.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X5

      UniProtKB/TrEMBL
      A6KQG5

    6. XM_017594823.2 → XP_017450312.1  A disintegrin and metalloproteinase with thrombospondin motifs 10 isoform X6

      UniProtKB/TrEMBL
      A6KQG5

    RNA

    1. XR_005486613.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001034930.1: Suppressed sequence

      Description
      NM_001034930.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from cow: ADAMTS10 (GeneID:513140).
    Nucleotide Protein Strain
    Heading Accession and Version

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