U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ZSWIM4 zinc finger SWIM-type containing 4 [ Homo sapiens (human) ]

    Gene ID: 65249, updated on 3-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ZSWIM4provided by HGNC
    Official Full Name
    zinc finger SWIM-type containing 4provided by HGNC
    Primary source
    HGNC:HGNC:25704
    See related
    Ensembl:ENSG00000132003 MIM:620539; AllianceGenome:HGNC:25704
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable zinc ion binding activity. Predicted to be part of Cul2-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in esophagus (RPKM 2.3), lung (RPKM 2.0) and 25 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    19p13.13-p13.12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (13795443..13832254)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (13921625..13958384)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (13906257..13943068)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10208 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:13876533-13877162 Neighboring gene methylthioribose-1-phosphate isomerase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14134 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14135 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:13885277-13885806 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:13885807-13886335 Neighboring gene chromosome 19 open reading frame 53 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:13896673-13897634 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14136 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10209 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10210 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14137 Neighboring gene uncharacterized LOC107985334 Neighboring gene MPRA-validated peak3376 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:13928069-13928736 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:13928737-13929405 Neighboring gene RNA, 7SL, cytoplasmic 619, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:13929406-13930073 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:13936598-13937294 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14139 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14140 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10211 Neighboring gene miR-23a/27a/24-2 cluster host gene Neighboring gene microRNA 24-2 Neighboring gene microRNA 27a

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. SWIM domain protein ZSWIM4 is required for JAK2 inhibition resistance in breast cancer. Gong K, et al. Life Sci, 2021 Aug 15. PMID 34102191
    2. Colonic transcriptional response to 1α,25(OH)(2) vitamin D(3) in African- and European-Americans. Alleyne D, et al. J Steroid Biochem Mol Biol, 2017 Apr. PMID 28163244, Free PMC Article
    3. Characterization of long cDNA clones from human adult spleen. Hattori A, et al. DNA Res, 2000 Dec 31. PMID 11214971
    4. ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection. Hüttenhain R, et al. Cell Host Microbe, 2019 Jul 10. PMID 31253590, Free PMC Article
    5. Genome-scale RNAi screen for host factors required for HIV replication. Zhou H, et al. Cell Host Microbe, 2008 Nov 13. PMID 18976975

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZSWIM4 inhibition improves chemosensitivity in epithelial ovarian cancer cells by suppressing intracellular glycine biosynthesis.
      Title: ZSWIM4 inhibition improves chemosensitivity in epithelial ovarian cancer cells by suppressing intracellular glycine biosynthesis.
    2. SWIM domain protein ZSWIM4 is required for JAK2 inhibition resistance in breast cancer.
      Title: SWIM domain protein ZSWIM4 is required for JAK2 inhibition resistance in breast cancer.
    3. there are inter-ethnic differences for uridine phosphorylase 1 (UPP1) and zinc finger-SWIM containing 4 (ZSWIM4) in response to 1alpha,25(OH)2D3
      Title: Colonic transcriptional response to 1α,25(OH)(2) vitamin D(3) in African- and European-Americans.
    Submit: New GeneRIF Correction

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

    Go to the top of the page Help

    Replication interactions

    Interaction Pubs
    Knockdown of zinc finger, SWIM-type containing 4 (ZSWIM4) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    zinc finger SWIM domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001367834.3 → NP_001354763.1  zinc finger SWIM domain-containing protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC020916
      Consensus CDS
      CCDS92534.1
      UniProtKB/TrEMBL
      K7ERJ6
      Related
      ENSP00000468285.2, ENST00000590508.6

    2. NM_023072.3 → NP_075560.2  zinc finger SWIM domain-containing protein 4 isoform 1

      See identical proteins and their annotated locations for NP_075560.2

      Status: VALIDATED

      Source sequence(s)
      AC020916, AK022283, AK024452, BG764264
      Consensus CDS
      CCDS32924.1
      UniProtKB/Swiss-Prot
      Q9H7M6
      Related
      ENSP00000254323.2, ENST00000254323.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      13795443..13832254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027153.2 → XP_016882642.1  zinc finger SWIM domain-containing protein 4 isoform X1

    2. XM_047439236.1 → XP_047295192.1  zinc finger SWIM domain-containing protein 4 isoform X6

    3. XM_017027155.2 → XP_016882644.1  zinc finger SWIM domain-containing protein 4 isoform X3

    4. XM_047439235.1 → XP_047295191.1  zinc finger SWIM domain-containing protein 4 isoform X4

    5. XM_017027154.2 → XP_016882643.1  zinc finger SWIM domain-containing protein 4 isoform X2

    6. XM_017027156.2 → XP_016882645.1  zinc finger SWIM domain-containing protein 4 isoform X8

      UniProtKB/TrEMBL
      B4DR14

    7. XM_047439237.1 → XP_047295193.1  zinc finger SWIM domain-containing protein 4 isoform X7

    8. XM_017027157.2 → XP_016882646.1  zinc finger SWIM domain-containing protein 4 isoform X9

    9. XM_024451657.2 → XP_024307425.1  zinc finger SWIM domain-containing protein 4 isoform X5

    RNA

    1. XR_007066949.1 RNA Sequence

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_021160022.1 Reference GRCh38.p14 PATCHES

      Range
      7284..44095
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332708.1 → XP_054188683.1  zinc finger SWIM domain-containing protein 4 isoform X1

    2. XM_054332713.1 → XP_054188688.1  zinc finger SWIM domain-containing protein 4 isoform X6

    3. XM_054332710.1 → XP_054188685.1  zinc finger SWIM domain-containing protein 4 isoform X3

    4. XM_054332711.1 → XP_054188686.1  zinc finger SWIM domain-containing protein 4 isoform X4

    5. XM_054332709.1 → XP_054188684.1  zinc finger SWIM domain-containing protein 4 isoform X2

    6. XM_054332715.1 → XP_054188690.1  zinc finger SWIM domain-containing protein 4 isoform X8

    7. XM_054332714.1 → XP_054188689.1  zinc finger SWIM domain-containing protein 4 isoform X7

    8. XM_054332716.1 → XP_054188691.1  zinc finger SWIM domain-containing protein 4 isoform X9

    9. XM_054332712.1 → XP_054188687.1  zinc finger SWIM domain-containing protein 4 isoform X5

    RNA

    1. XR_008485786.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      13921625..13958384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321793.1 → XP_054177768.1  zinc finger SWIM domain-containing protein 4 isoform X1

    2. XM_054321798.1 → XP_054177773.1  zinc finger SWIM domain-containing protein 4 isoform X6

    3. XM_054321795.1 → XP_054177770.1  zinc finger SWIM domain-containing protein 4 isoform X3

    4. XM_054321796.1 → XP_054177771.1  zinc finger SWIM domain-containing protein 4 isoform X4

    5. XM_054321794.1 → XP_054177769.1  zinc finger SWIM domain-containing protein 4 isoform X2

    6. XM_054321799.1 → XP_054177774.1  zinc finger SWIM domain-containing protein 4 isoform X9

    7. XM_054321797.1 → XP_054177772.1  zinc finger SWIM domain-containing protein 4 isoform X5

    RNA

    1. XR_008485178.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H7M6.3 GenPept UniProtKB/Swiss-Prot:Q9H7M6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous