TRIM67 tripartite motif containing 67 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRIM67provided by HGNC
Official Full Name: tripartite motif containing 67provided by HGNC
Primary source: HGNC:HGNC:31859
See related: Ensembl:ENSG00000119283 MIM:610584; AllianceGenome:HGNC:31859
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TNL
Summary: Predicted to enable zinc ion binding activity. Predicted to be involved in regulation of protein localization. Predicted to act upstream of or within negative regulation of Ras protein signal transduction; positive regulation of neuron projection development; and positive regulation of ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm and cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in brain (RPKM 4.1) and adrenal (RPKM 0.2) See more
Orthologs: mouse all
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Genomic context

Location:: 1q42.2

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (231162058..231221565)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (230544922..230604828)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (231297804..231357311)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRIM67 interacts with ENAH to regulate the apoptosis and autophagy of lung cancer cells.
Title: TRIM67 interacts with ENAH to regulate the apoptosis and autophagy of lung cancer cells.
Loss of TRIM67 Attenuates the Progress of Obesity-Induced Non-Alcoholic Fatty Liver Disease.
Title: Loss of TRIM67 Attenuates the Progress of Obesity-Induced Non-Alcoholic Fatty Liver Disease.
TRIM67 functions as a pivotal tumor suppressor in colorectal cancer.Epigenetic silencing of TRIM67 correlates with poor survival in patients with colorectal cancer.TRIM67 stabilizes p53 and activates p53 signaling pathway.TRIM67 is a direct target gene of p53.
Title: TRIM67 Activates p53 to Suppress Colorectal Cancer Initiation and Progression.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH123344 (e-PCR)
- UniSTS:135721

D14S96E (e-PCR)
- UniSTS:147528

RH27924 (e-PCR)
- UniSTS:66124

HSC2BE102 (e-PCR)
- UniSTS:21467

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of Ras protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein localization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tripartite motif-containing protein 67

Names: TRIM9-like protein TNL

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004342.5 → NP_001004342.3 tripartite motif-containing protein 67 isoform 1

See identical proteins and their annotated locations for NP_001004342.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AL109810, AL137801

Consensus CDS

CCDS44333.1

UniProtKB/Swiss-Prot

Q5TER7, Q5TER8, Q6ZTA4, Q7Z4K7

Related

ENSP00000355613.5, ENST00000366653.6

Conserved Domains (5) summary

smart00502
Location:347 → 473

BBC; B-Box C-terminal domain

cd00063
Location:528 → 604

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00643
Location:301 → 340

zf-B_box; B-box zinc finger

cd12889
Location:601 → 772

SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67

cl17238
Location:7 → 45

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
NM_001300889.3 → NP_001287818.1 tripartite motif-containing protein 67 isoform 2

See identical proteins and their annotated locations for NP_001287818.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks two alternate in-frame segments in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AL109810, AL137801

Consensus CDS

CCDS73048.1

UniProtKB/Swiss-Prot

Q6ZTA4

Related

ENSP00000400163.3, ENST00000449018.7

Conserved Domains (5) summary

smart00502
Location:285 → 411

BBC; B-Box C-terminal domain

cd00063
Location:466 → 542

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00643
Location:239 → 278

zf-B_box; B-box zinc finger

cd12889
Location:539 → 710

SPRY_PRY_TRIM67_9; PRY/SPRY domain in tripartite motif-containing proteins, TRIM9 and TRIM67

cl17238
Location:7 → 30

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
NM_001410937.1 → NP_001397866.1 tripartite motif-containing protein 67 isoform 3

Status: VALIDATED

Source sequence(s)

AL109810, AL137801

Consensus CDS

CCDS91173.1

UniProtKB/TrEMBL

F8W8C1

Related

ENSP00000412124.3, ENST00000444294.7