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    CDCA7L cell division cycle associated 7 like [ Homo sapiens (human) ]

    Gene ID: 55536, updated on 5-Mar-2024

    Summary

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    Official Symbol
    CDCA7Lprovided by HGNC
    Official Full Name
    cell division cycle associated 7 likeprovided by HGNC
    Primary source
    HGNC:HGNC:30777
    See related
    Ensembl:ENSG00000164649 MIM:609685; AllianceGenome:HGNC:30777
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    R1; JPO2; RAM2
    Summary
    Acts upstream of or within positive regulation of cell population proliferation. Located in cytosol; fibrillar center; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in thyroid (RPKM 17.0), bone marrow (RPKM 16.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    7p15.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (21900899..21945899, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (22037210..22082187, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (21940517..21985517, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene dynein axonemal heavy chain 11 Neighboring gene uncharacterized LOC124901599 Neighboring gene uncharacterized LOC107986775 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:21937780-21938979 Neighboring gene NANOG hESC enhancer GRCh37_chr7:21981192-21981812 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25702 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:21985471-21986181 Neighboring gene VISTA enhancer hs807 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 7:22097966 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 7:22117733 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 7:22118756 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 7:22119917 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 7:22121421 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 7:22123422 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 7:22141595 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17999 Neighboring gene NANOG hESC enhancer GRCh37_chr7:22218362-22218864 Neighboring gene Rap guanine nucleotide exchange factor 5 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr7:22224198-22225096 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:22281835-22282335 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:22369304-22369804 Neighboring gene RNA, 5S ribosomal pseudogene 227 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25704 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25705 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18001 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18002 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25706 Neighboring gene HNF4 motif-containing MPRA enhancer 142 Neighboring gene GATA motif-containing MPRA enhancer 55/56 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25707 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25708 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:22517166-22517666 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:22517667-22518167 Neighboring gene STEAP family member 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. CDCA7L promotes glioma proliferation by targeting CCND1 and predicts an unfavorable prognosis. Ji QK, et al. Mol Med Rep, 2019 Aug. PMID 31173217, Free PMC Article
    2. Cell division cycle associated 7 like predicts unfavorable prognosis and promotes invasion in glioma. Shen FZ, et al. Pathol Res Pract, 2019 Jan. PMID 30389317
    3. Multiple myeloma risk variant at 7p15.3 creates an IRF4-binding site and interferes with CDCA7L expression. Li N, et al. Nat Commun, 2016 Nov 24. PMID 27882933, Free PMC Article
    4. CDCA7L promotes hepatocellular carcinoma progression by regulating the cell cycle. Tian Y, et al. Int J Oncol, 2013 Dec. PMID 24141559
    5. The reduction of R1, a novel repressor protein for monoamine oxidase A, in major depressive disorder. Johnson S, et al. Neuropsychopharmacology, 2011 Sep. PMID 21654740, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results identified and confirmed to have downregulated gene expression of SFRP5 in sporadic nonfunctioning pancreatic neuroendocrine tumors (NFPanNETs) and CDCA7L and RBM47 in MEN1-related NFPanNETs.
      Title: Distinct genome-wide methylation patterns in sporadic and hereditary nonfunctioning pancreatic neuroendocrine tumors.
    2. CDCA7L is highly expressed in human glioma tissues and that a high CDCA7L expression predicts a poor prognosis of glioma patients. CDCA7L promotes glioma U87 cell growth through CCND1.
      Title: CDCA7L promotes glioma proliferation by targeting CCND1 and predicts an unfavorable prognosis.
    3. Study demonstrated the elevated expression of R1 in human prostate cancer tissue and cell lines at both protein and mRNA levels. Further results provide evidence that R1 is a novel regulator of prostate tumor growth by stabilizing c-Myc protein through transcriptional suppression of HUWE1.
      Title: R1 Regulates Prostate Tumor Growth and Progression By Transcriptional Suppression of the E3 Ligase HUWE1 to Stabilize c-Myc.
    4. CDCA7L is highly expressed in human glioma tissues and a high CDCA7L expression level predicts the dismal prognosis for glioma patients
      Title: Cell division cycle associated 7 like predicts unfavorable prognosis and promotes invasion in glioma.
    5. Suppression of CDCA7L limits multiple myeloma proliferation through apoptosis.
      Title: Multiple myeloma risk variant at 7p15.3 creates an IRF4-binding site and interferes with CDCA7L expression.
    6. We identify the Myc-interacting protein JPO2 and its partner binding protein LEDGF/p75 as critical modulators of PI3K/AKT signaling and metastasis in medulloblastoma
      Title: JPO2/CDCA7L and LEDGF/p75 Are Novel Mediators of PI3K/AKT Signaling and Aggressive Phenotypes in Medulloblastoma.
    7. common LEDGF/p75 interaction interface shared by JPO2, PogZ, MLL1, IWS1 and HIV IN
      Title: Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif.
    8. The data are consistent with the rs4487645-CDCA7L loci being responsible for the chromosome 7p11.2 association with multiple myeloma risk, probably exerting its effects through an extended pathway involving IRF4 and MYC.
      Title: The 7p15.3 (rs4487645) association for multiple myeloma shows strong allele-specific regulation of the MYC-interacting gene CDCA7L in malignant plasma cells.
    9. Data indicate that JPO2 and LEDGF/p75 interact directly and specifically in vivo through the specific interaction domain of JPO2 and the C-terminal domain of LEDGF/p75.
      Title: Dynamics of the ternary complex formed by c-Myc interactor JPO2, transcriptional co-activator LEDGF/p75, and chromatin.
    10. CDCA7L was able to activate the extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway and regulate the cell cycle, thus promoting HCC progression.
      Title: CDCA7L promotes hepatocellular carcinoma progression by regulating the cell cycle.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat downregulates the expression of cell division cycle associated 7-like (CDCA7L; JPO2) in human primary T cells PubMed
    tat HIV-1 Tat-mediated stimulation of the viral LTR is increased in the presence of JPO2 PubMed
    integrase gag-pol Both HIV-1 IN and JPO2 proteins are present as oligomers and co-localize in the nucleus of HeLa cells PubMed
    gag-pol The IN catalytic core domain has a higher binding affinity (Kd) for PSIP1 (LEDGF/p75) than the physiological binding partner, CDCA7L (JOP2) PubMed
    gag-pol The HIV-1 IN interaction site on the PSIP1 (LEDGF/p75) intergrase binding domain (IBD) overlaps with that of JPO2 PubMed
    gag-pol HIV-1 IN and JPO2 bind mutually exclusively to LEDGF/p75. Two LEDGF/p75 mutants (I365A and D366N) abrogate interaction between LEDGF/p75 and IN but interact with JPO2 to the same extent as wild-type LEDGF/p75 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp762L0311

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in fibrillar center IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cell division cycle-associated 7-like protein
    Names
    transcription factor RAM2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127370.3 → NP_001120842.1  cell division cycle-associated 7-like protein isoform 2

      See identical proteins and their annotated locations for NP_001120842.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate exon in the 5' UTR which results in the use of a downstream start codon, compared to variant 1. Isoform 2 has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AA922229, AK022955, AK095965, AL576822, BC009352, BU753973, DA041070
      Consensus CDS
      CCDS47559.1
      UniProtKB/TrEMBL
      A8K8X5
      Related
      ENSP00000348523.5, ENST00000356195.9
      Conserved Domains (1) summary
      pfam10497
      Location:311 → 409
      zf-4CXXC_R1; Zinc-finger domain of monoamine-oxidase A repressor R1

    2. NM_001127371.3 → NP_001120843.1  cell division cycle-associated 7-like protein isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame coding exon, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AA922229, AK022955, AK300781, AL576822, BU753973, BX422040, DC331792
      Consensus CDS
      CCDS47558.1
      UniProtKB/TrEMBL
      A8K8X5
      Related
      ENSP00000363045.4, ENST00000373934.4
      Conserved Domains (1) summary
      pfam10497
      Location:299 → 397
      zf-4CXXC_R1; Zinc-finger domain of monoamine-oxidase A repressor R1

    3. NM_018719.5 → NP_061189.2  cell division cycle-associated 7-like protein isoform 1

      See identical proteins and their annotated locations for NP_061189.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the predominant and longest protein (isoform 1).
      Source sequence(s)
      AA922229, AK022955, AK292490, AL576822, BC009352, BU753973
      Consensus CDS
      CCDS5374.1
      UniProtKB/Swiss-Prot
      A4D141, A6NF50, B3KTR5, B4DUT3, C9K0Y1, Q6PIL4, Q86YT0, Q8IXN5, Q96C70, Q96GN5, Q9H9A2, Q9NPV2
      UniProtKB/TrEMBL
      A8K8X5
      Related
      ENSP00000383986.3, ENST00000406877.8
      Conserved Domains (1) summary
      pfam10497
      Location:345 → 443
      zf-4CXXC_R1; Zinc-finger domain of monoamine-oxidase A repressor R1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      21900899..21945899 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      22037210..22082187 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96GN5.2 GenPept UniProtKB/Swiss-Prot:Q96GN5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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