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    KIAA0319l KIAA0319 like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100294508, updated on 3-Apr-2024

    Summary

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    Official Symbol
    KIAA0319lprovided by RGD
    Official Full Name
    KIAA0319 likeprovided by RGD
    Primary source
    RGD:2306719
    See related
    Ensembl:ENSRNOG00000012204 AllianceGenome:RGD:2306719
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to act upstream of or within several processes, including flagellated sperm motility; proacrosomal vesicle fusion; and receptor-mediated endocytosis of virus by host cell. Predicted to be located in nucleolus and trans-Golgi network. Predicted to be active in cytoplasmic vesicle and plasma membrane. Orthologous to human KIAA0319L (KIAA0319 like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 190.9), Adrenal (RPKM 173.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See KIAA0319l in Genome Data Viewer
    Location:
    5q36
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (144332242..144425182)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (139047847..139140709)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (144779306..144872271)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene transcription factor AP-2 epsilon Neighboring gene neurochondrin Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134486992 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene zinc finger MYM-type containing 4 Neighboring gene ribosomal protein L35A, pseudogene 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. AU040320 deficiency leads to disruption of acrosome biogenesis and infertility in homozygous mutant mice. Guidi LG, et al. Sci Rep, 2018 Jul 10. PMID 29991750, Free PMC Article
    2. An essential receptor for adeno-associated virus infection. Pillay S, et al. Nature, 2016 Feb 4. PMID 26814968, Free PMC Article
    3. Dyslexia-associated kiaa0319-like protein interacts with axon guidance receptor nogo receptor 1. Poon MW, et al. Cell Mol Neurobiol, 2011 Jan. PMID 20697954
    4. Knockout Mice for Dyslexia Susceptibility Gene Homologs KIAA0319 and KIAA0319L have Unaffected Neuronal Migration but Display Abnormal Auditory Processing. Guidi LG, et al. Cereb Cortex, 2017 Dec 1. PMID 29045729, Free PMC Article
    5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within acrosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within proacrosomal vesicle fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within receptor-mediated endocytosis of virus by host cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to auditory stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dyslexia-associated protein KIAA0319-like protein homolog
    Names
    dyslexia susceptibility 2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159655.4 → NP_001153127.1  dyslexia-associated protein KIAA0319-like protein homolog

      See identical proteins and their annotated locations for NP_001153127.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6ISB7
      Related
      ENSRNOP00000016493.6, ENSRNOT00000016493.7
      Conserved Domains (4) summary
      smart00089
      Location:409 → 495
      PKD; Repeats in polycystic kidney disease 1 (PKD1) and other proteins
      pfam02010
      Location:629 → 807
      REJ; REJ domain
      pfam07974
      Location:891 → 911
      EGF_2; EGF-like domain
      pfam18911
      Location:583 → 672
      PKD_4; PKD domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      144332242..144425182
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287023.1 → XP_063143093.1  dyslexia-associated protein KIAA0319-like protein homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I6APE1

    2. XM_063287024.1 → XP_063143094.1  dyslexia-associated protein KIAA0319-like protein homolog isoform X2

      UniProtKB/TrEMBL
      F1M4J1

    3. XM_063287025.1 → XP_063143095.1  dyslexia-associated protein KIAA0319-like protein homolog isoform X2

      UniProtKB/TrEMBL
      F1M4J1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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