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    Ankrd50 ankyrin repeat domain 50 [ Mus musculus (house mouse) ]

    Gene ID: 99696, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Ankrd50provided by MGI
    Official Full Name
    ankyrin repeat domain 50provided by MGI
    Primary source
    MGI:MGI:2139777
    See related
    Ensembl:ENSMUSG00000044864 AllianceGenome:MGI:2139777
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1223; mKIAA3019; E430012K20Rik
    Summary
    Predicted to be involved in endocytic recycling. Orthologous to human ANKRD50 (ankyrin repeat domain 50). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lung adult (RPKM 12.5), thymus adult (RPKM 11.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ankrd50 in Genome Data Viewer
    Location:
    3 B; 3 18.49 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (38503408..38539005, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (38449259..38484862, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42213 Neighboring gene STARR-seq mESC enhancer starr_07447 Neighboring gene predicted gene, 36823 Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 22 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2663 Neighboring gene STARR-seq mESC enhancer starr_07448 Neighboring gene STARR-seq mESC enhancer starr_07449 Neighboring gene STARR-seq mESC enhancer starr_07450 Neighboring gene STARR-seq mESC enhancer starr_07451 Neighboring gene ferritin light chain 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_07452 Neighboring gene predicted gene, 29879

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    2. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1223

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 50
    Names
    ankrin repeat domain 50

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167883.1 → NP_001161355.1  ankyrin repeat domain-containing protein 50 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC127284
      Consensus CDS
      CCDS50897.1
      UniProtKB/TrEMBL
      D3Z643, Q6ZPE3
      Related
      ENSMUSP00000113349.2, ENSMUST00000120875.8
      Conserved Domains (1) summary
      pfam13191
      Location:23 → 195
      AAA_16; AAA ATPase domain

    2. NM_001373894.1 → NP_001360823.1  ankyrin repeat domain-containing protein 50 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC127284
      UniProtKB/TrEMBL
      F7BE84
      Conserved Domains (6) summary
      PHA02876
      Location:763 → 1102
      PHA02876; ankyrin repeat protein; Provisional
      PHA03095
      Location:625 → 907
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:676 → 707
      ANK; ANK repeat [structural motif]
      pfam15440
      Location:1225 → 1339
      THRAP3_BCLAF1; THRAP3/BCLAF1 family
      pfam13191
      Location:23 → 195
      AAA_16; AAA ATPase domain
      cl27783
      Location:251 → 352
      Cas9_REC; REC lobe of CRISPR-associated endonuclease Cas9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      38503408..38539005 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535582.5 → XP_006535645.1  ankyrin repeat domain-containing protein 50 isoform X1

      See identical proteins and their annotated locations for XP_006535645.1

      UniProtKB/TrEMBL
      F7BE84
      Related
      ENSMUSP00000122842.2, ENSMUST00000156038.2
      Conserved Domains (6) summary
      PHA02876
      Location:763 → 1102
      PHA02876; ankyrin repeat protein; Provisional
      PHA03095
      Location:625 → 907
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:676 → 707
      ANK; ANK repeat [structural motif]
      pfam15440
      Location:1225 → 1339
      THRAP3_BCLAF1; THRAP3/BCLAF1 family
      pfam13191
      Location:23 → 195
      AAA_16; AAA ATPase domain
      cl27783
      Location:251 → 352
      Cas9_REC; REC lobe of CRISPR-associated endonuclease Cas9

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033198.2: Suppressed sequence

      Description
      NM_001033198.2: This RefSeq was temporarily suppressed because the CDS was partial.
    Nucleotide Protein Strain
    Heading Accession and Version

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