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    Golim4 golgi integral membrane protein 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310526, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Golim4provided by RGD
    Official Full Name
    golgi integral membrane protein 4provided by RGD
    Primary source
    RGD:1310948
    See related
    Ensembl:ENSRNOG00000024213 AllianceGenome:RGD:1310948
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Golph4
    Summary
    Predicted to be located in Golgi cisterna membrane; Golgi membrane; and endosome membrane. Predicted to be active in Golgi apparatus. Predicted to be integral component of membrane. Orthologous to human GOLIM4 (golgi integral membrane protein 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 157.8), Lung (RPKM 135.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    2q32
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (162939429..163031901, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (160640837..160733475, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (174321303..174413847, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC108350036 Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 46 Neighboring gene uncharacterized LOC102547227 Neighboring gene follistatin-like 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Sequence and overexpression of GPP130/GIMPc: evidence for saturable pH-sensitive targeting of a type II early Golgi membrane protein. Linstedt AD, et al. Mol Biol Cell, 1997 Jun. PMID 9201717, Free PMC Article
    2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    Golgi integral membrane protein 4
    Names
    GIMPc
    golgi integral membrane protein, cis
    golgi phosphoprotein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399468.1 → NP_001386397.1  Golgi integral membrane protein 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      Related
      ENSRNOP00000073317.2, ENSRNOT00000089229.2
      Conserved Domains (2) summary
      pfam10186
      Location:108 → 248
      Atg14; Vacuolar sorting 38 and autophagy-related subunit 14
      NF012221
      Location:174 → 555
      MARTX_Nterm; MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region

    2. NM_001399469.1 → NP_001386398.1  Golgi integral membrane protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q5BJK8
      Related
      ENSRNOP00000035176.3, ENSRNOT00000037115.6
      Conserved Domains (2) summary
      COG1196
      Location:33 → 309
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      NF012221
      Location:243 → 527
      MARTX_Nterm; MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      162939429..163031901 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001191567.1: Suppressed sequence

      Description
      NM_001191567.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BJK8.2 GenPept UniProtKB/Swiss-Prot:Q5BJK8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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