Vwf von Willebrand factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Vwfprovided by RGD
Official Full Name: von Willebrand factorprovided by RGD
Primary source: RGD:621759
See related: Ensembl:ENSRNOG00000019689 AllianceGenome:RGD:621759
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including chaperone binding activity; identical protein binding activity; and integrin binding activity. Involved in several processes, including liver regeneration; platelet activation; and response to L-ascorbic acid. Located in collagen-containing extracellular matrix; endoplasmic reticulum; and extracellular space. Used to study transient cerebral ischemia. Biomarker of hypertension; mesangial proliferative glomerulonephritis; myocardial infarction; pulmonary fibrosis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; Bernard-Soulier syndrome; end stage renal disease; essential thrombocythemia; and von Willebrand's disease (multiple). Orthologous to human VWF (von Willebrand factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 693.9), Heart (RPKM 222.5) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 53

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (160042900..160177757)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (158360152..158491539)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (158085059..158219525)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Von Willebrand Factor Gene Variants Associate with Herpes simplex Encephalitis
Title: Von Willebrand Factor Gene Variants Associate with Herpes simplex Encephalitis.
Radix et Rhizoma Rhodiolae Kirilowii may promote angiogenesis in myocardium of rats with AMI through elevating the expressions of HIF-1alpha, HIF-1beta, and VEGF.
Title: Effects of Radix et Rhizoma Rhodiolae Kirilowii on expressions of von Willebrand factor, hypoxia-inducible factor 1 and vascular endothelial growth factor in myocardium of rats with acute myocardial infarction.
certain inflammatory cytokines selectively inhibit ADAMTS13 synthesis without triggering release of its known substrate, vWF.
Title: Inflammatory cytokines inhibit ADAMTS13 synthesis in hepatic stellate cells and endothelial cells.
After partial hepatectomy, plasma vWf is increased, probably due to both acute-phase reaction and decreased degradation and increase in sinusoidal vWf immunostaining may suggest a role for this factor in tissue remodeling.
Title: Von Willebrand factor in plasma and in liver tissue after partial hepatectomy in the rat.
fibronectin assembly has a role in platelet thrombus formation in response to type I collagen and von Willebrand factor
Title: Impact of fibronectin assembly on platelet thrombus formation in response to type I collagen and von Willebrand factor.

Submit: New GeneRIF Correction

General gene information

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Markers

D4Wox36 (e-PCR)
- UniSTS:518663

Vwf (e-PCR), detects polymorphism
- UniSTS:144762

RH132777 (e-PCR)
- UniSTS:216060

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables collagen binding	IEA Inferred from Electronic Annotation more info
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables immunoglobulin binding	IEA Inferred from Electronic Annotation more info
enables immunoglobulin binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables protease binding	IEA Inferred from Electronic Annotation more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein-folding chaperone binding	IEA Inferred from Electronic Annotation more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within activation of blood coagulation via clotting cascade	ISO Inferred from Sequence Orthology more info
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-substrate adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cold	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within hemostasis	ISO Inferred from Sequence Orthology more info
involved_in hemostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within liver development	ISO Inferred from Sequence Orthology more info
involved_in liver regeneration	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within placenta development	ISO Inferred from Sequence Orthology more info
involved_in platelet activation	IEA Inferred from Electronic Annotation more info
NOT acts_upstream_of_or_within platelet activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within platelet activation	ISO Inferred from Sequence Orthology more info
involved_in platelet activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in response to L-ascorbic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to X-ray	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to immobilization stress	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in Weibel-Palade body	IEA Inferred from Electronic Annotation more info
located_in Weibel-Palade body	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: von Willebrand factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053889.1 → NP_446341.1 von Willebrand factor precursor

See identical proteins and their annotated locations for NP_446341.1

Status: VALIDATED

Source sequence(s)

BK007994

UniProtKB/TrEMBL

A0A8J8XVZ5, A6ILU6

Related

ENSRNOP00000026643.8, ENSRNOT00000026643.8

Conserved Domains (11) summary

smart00041
Location:2726 → 2807

CT; C-terminal cystine knot-like domain (CTCK)

smart00214
Location:2431 → 2494

VWC; von Willebrand factor (vWF) type C domain

smart00216
Location:377 → 540

VWD; von Willebrand factor (vWF) type D domain

smart00327
Location:1277 → 1449

VWA; von Willebrand factor (vWF) type A domain

smart00832
Location:1053 → 1127

C8; This domain contains 8 conserved cysteine residues

pfam00092
Location:1498 → 1658

VWA; von Willebrand factor type A domain

pfam00094
Location:35 → 179

VWD; von Willebrand factor type D domain

pfam01826
Location:652 → 707

TIL; Trypsin Inhibitor like cysteine rich domain

pfam08742
Location:2136 → 2199

C8; C8 domain

pfam16164
Location:1198 → 1276

VWA_N2; VWA N-terminal

cl17735
Location:2581 → 2643

VWC; von Willebrand factor type C domain