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    Ppp1r42 protein phosphatase 1, regulatory subunit 42 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 683514, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Ppp1r42provided by RGD
    Official Full Name
    protein phosphatase 1, regulatory subunit 42provided by RGD
    Primary source
    RGD:1585679
    See related
    Ensembl:ENSRNOG00000006804 AllianceGenome:RGD:1585679
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin binding activity; dynein complex binding activity; and tubulin binding activity. Predicted to be involved in regulation of phosphatase activity. Predicted to be located in centrosome and manchette. Orthologous to human PPP1R42 (protein phosphatase 1 regulatory subunit 42). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 111.5), Lung (RPKM 10.6) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppp1r42 in Genome Data Viewer
    Location:
    5q11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (14009972..14057330)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (9227109..9274461)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (8911356..8956313)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene centrosome and spindle pole associated protein 1 Neighboring gene COP9 signalosome subunit 5 Neighboring gene RNA, U6 small nuclear 1297 Neighboring gene uncharacterized LOC102556004 Neighboring gene transcription factor 24 Neighboring gene minichromosome maintenance domain containing 2 Neighboring gene small nucleolar RNA, C/D box 87

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PP1 forms an active complex with TLRR (lrrc67), a putative PP1 regulatory subunit, during the early stages of spermiogenesis in mice. Wang R, et al. PLoS One, 2011. PMID 21738792, Free PMC Article
    2. Identification of a novel Leucine-rich repeat protein and candidate PP1 regulatory subunit expressed in developing spermatids. Wang R, et al. BMC Cell Biol, 2008 Jan 31. PMID 18237440, Free PMC Article
    3. TLRR (lrrc67) interacts with PP1 and is associated with a cytoskeletal complex in the testis. Wang R, et al. Biol Cell, 2010 Jan 13. PMID 19886865, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dynein complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in manchette ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule organizing center ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 1 regulatory subunit 42

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127569.2 → NP_001121041.1  protein phosphatase 1 regulatory subunit 42

      See identical proteins and their annotated locations for NP_001121041.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A9K3Y8A7, B1WBU1, E9PTW7
      Related
      ENSRNOP00000061242.2, ENSRNOT00000066395.3
      Conserved Domains (2) summary
      sd00033
      Location:30 → 51
      LRR_RI; leucine-rich repeat [structural motif]
      cd21340
      Location:27 → 246
      PPP1R42; protein phosphatase 1 regulatory subunit 42

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      14009972..14057330
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288419.1 → XP_063144489.1  protein phosphatase 1 regulatory subunit 42 isoform X1

    2. XM_039110784.2 → XP_038966712.1  protein phosphatase 1 regulatory subunit 42 isoform X2

      Conserved Domains (1) summary
      cd21340
      Location:2 → 81
      PPP1R42; protein phosphatase 1 regulatory subunit 42
    Nucleotide Protein Strain
    Heading Accession and Version

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