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    Zfp386 zinc finger protein 386 (Kruppel-like) [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25165, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Zfp386provided by RGD
    Official Full Name
    zinc finger protein 386 (Kruppel-like)provided by RGD
    Primary source
    RGD:2985
    See related
    AllianceGenome:RGD:2985
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kzf1; Znf386
    Summary
    Enables DNA binding activity. Involved in negative regulation of transcription involved in meiotic cell cycle and spermatogenesis. Predicted to be active in nucleus. Orthologous to human ZNF519 (zinc finger protein 519). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 123.0), Adrenal (RPKM 121.7) and 9 other tissues See more
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    Genomic context

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    See Zfp386 in Genome Data Viewer
    Location:
    6q33
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (143109563..143124266)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (136966547..136984013)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (143901239..143915953)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene immunoglobulin heavy variable 2-70-like Neighboring gene Ig heavy chain V region 3-like Neighboring gene vasoactive intestinal peptide receptor 2 Neighboring gene chromatin target of PRMT1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Kzf1 - a novel KRAB zinc finger protein encoding gene expressed during rat spermatogenesis. Bellefroid EJ, et al. Biochim Biophys Acta, 1998 Jul 9. PMID 9655926
    2. Identification of potential nuclear reprogramming and differentiation factors by a novel selection method for cloning chromatin-binding proteins. Wang L, et al. Biochem Biophys Res Commun, 2004 Dec 3. PMID 15522233
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 386 (Kruppel-like)
    Names
    Kruppel associated box (KRAB) zinc finger 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019620.3 → NP_062566.3  zinc finger protein 386 (Kruppel-like)

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      Q6AYY1
      Conserved Domains (4) summary
      COG5048
      Location:424 → 584
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:456 → 476
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:6 → 45
      KRAB; KRAB box
      pfam13465
      Location:384 → 409
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      143109563..143124266
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111798.2 → XP_038967726.1  zinc finger protein 386 (Kruppel-like) isoform X3

      Conserved Domains (1) summary
      smart00349
      Location:6 → 47
      KRAB; krueppel associated box

    2. XM_039111799.2 → XP_038967727.1  zinc finger protein 386 (Kruppel-like) isoform X4

      Conserved Domains (1) summary
      smart00349
      Location:6 → 49
      KRAB; krueppel associated box

    3. XM_063261557.1 → XP_063117627.1  zinc finger protein 386 (Kruppel-like) isoform X1

    4. XM_063261558.1 → XP_063117628.1  zinc finger protein 386 (Kruppel-like) isoform X2

    5. XM_039111797.2 → XP_038967725.1  zinc finger protein 386 (Kruppel-like) isoform X2

      Conserved Domains (3) summary
      COG5048
      Location:327 → 487
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:359 → 379
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:287 → 312
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. XR_005505444.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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