Klre1 killer cell lectin like receptor E1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Klre1provided by RGD
Official Full Name: killer cell lectin like receptor E1provided by RGD
Primary source: RGD:727903
See related: Ensembl:ENSRNOG00000058714 AllianceGenome:RGD:727903
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables identical protein binding activity and protein phosphatase binding activity. Involved in negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target. Located in cell surface. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 81.4), Lung (RPKM 45.1) and 6 other tissues See more
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Genomic context

Location:: 4q42

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (164719307..164727664)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (163033581..163041641)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (163346684..163355050)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KLRE-KLRI1 heterodimer is a functional inhibitory heterodimer in NK cells; KLRE1-KLRI2 heterodimer is a functional activating heterodimer in NK cells
Title: KLRE/I1 and KLRE/I2: a novel pair of heterodimeric receptors that inversely regulate NK cell cytotoxicity.
cloning and functional characterization of a novel natural killer (NK) cell receptor termed KLRE1
Title: The lectin-like receptor KLRE1 inhibits natural killer cell cytotoxicity.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of natural killer cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of natural killer cell mediated cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in stimulatory C-type lectin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: killer cell lectin-like receptor subfamily E member 1

Names: NK cell lectin-like receptor family E, member 1; killer cell lectin-like receptor, family E, member 1; killer cell lectin-like receptor, subfamily E, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418987.1 → NP_001405916.1 killer cell lectin-like receptor subfamily E member 1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

Related

ENSRNOP00000074069.2, ENSRNOT00000084823.2
NM_181372.3 → NP_852037.1 killer cell lectin-like receptor subfamily E member 1 isoform 1

See identical proteins and their annotated locations for NP_852037.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

Q80ST4, Q80ZC8

Conserved Domains (1) summary

cd03593
Location:113 → 226

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)