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    Tie1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 89806, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Tie1provided by RGD
    Official Full Name
    tyrosine kinase with immunoglobulin-like and EGF-like domains 1provided by RGD
    Primary source
    RGD:621642
    See related
    Ensembl:ENSRNOG00000020173 AllianceGenome:RGD:621642
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable transmembrane receptor protein tyrosine kinase activity. Involved in vasculogenesis. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human TIE1 (tyrosine kinase with immunoglobulin like and EGF like domains 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 360.0), Heart (RPKM 236.5) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tie1 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (137285408..137305047, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (132000013..132019658, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (137294544..137321116, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103692460 Neighboring gene U6 spliceosomal RNA Neighboring gene MPL proto-oncogene, thrombopoietin receptor Neighboring gene uncharacterized LOC102554074 Neighboring gene transmembrane protein 258 like 2 Neighboring gene ribosomal protein S5, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of tie1 and tie2 proteins during reendothelialization in balloon-injured rat carotid artery. Fujikawa K, et al. J Vasc Res, 1999 Jul-Aug. PMID 10474040
    2. Stretch induces upregulation of key tyrosine kinase receptors in microvascular endothelial cells. Zheng W, et al. Am J Physiol Heart Circ Physiol, 2004 Dec. PMID 15548727
    3. Enhanced expression of angiopoietin-2 and the Tie2 receptor but not angiopoietin-1 or the Tie1 receptor in a rat model of myocardial infarction. Shyu KG, et al. J Biomed Sci, 2004 Mar-Apr. PMID 14966366
    4. A combinatorial role of angiopoietin-1 and orphan receptor TIE1 pathways in establishing vascular polarity during angiogenesis. Loughna S, et al. Mol Cell, 2001 Jan. PMID 11172728
    5. TIE1 and TIE2 receptor tyrosine kinases inversely regulate embryonic angiogenesis by the mechanism of intussusceptive microvascular growth. Patan S. Microvasc Res, 1998 Jul. PMID 9683559

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ang2 and Tie2 expressions significantly increased both spatial and temporal patterns after myocardial infarction in the rat ventricular myocardium, while Ang1 and Tie1 receptor expression did not.
      Title: Enhanced expression of angiopoietin-2 and the Tie2 receptor but not angiopoietin-1 or the Tie1 receptor in a rat model of myocardial infarction.
    2. Mechanical stretch induces upregulation of the key tyrosine kinase receptors Flk-1, Tie-2, and Tie-1 in vascular endothelial cells
      Title: Stretch induces upregulation of key tyrosine kinase receptors in microvascular endothelial cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in aortic valve morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within blood vessel development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in branching involved in lymph vessel morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lymphatic endothelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within plasma membrane fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of regulation of extracellular matrix assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to retinoic acid ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tissue remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vasculogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein kinase receptor Tie-1
    Names
    tyrosine kinase receptor 1
    NP_445997.1
    XP_006238782.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053545.1 → NP_445997.1  tyrosine-protein kinase receptor Tie-1 precursor

      See identical proteins and their annotated locations for NP_445997.1

      Status: PROVISIONAL

      Source sequence(s)
      BC169020
      UniProtKB/TrEMBL
      A6JZI8, B5DFD6
      Related
      ENSRNOP00000027414.5, ENSRNOT00000027414.8
      Conserved Domains (8) summary
      smart00219
      Location:838 → 1106
      TyrKc; Tyrosine kinase, catalytic domain
      smart00410
      Location:370 → 444
      IG_like; Immunoglobulin like
      cd00054
      Location:315 → 346
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:228 → 266
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00063
      Location:643 → 735
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05089
      Location:835 → 1131
      PTKc_Tie1; Catalytic domain of the Protein Tyrosine Kinase, Tie1
      pfam00041
      Location:549 → 631
      fn3; Fibronectin type III domain
      pfam00047
      Location:130 → 211
      ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      137285408..137305047 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238720.4 → XP_006238782.1  tyrosine-protein kinase receptor Tie-1 isoform X1

      UniProtKB/TrEMBL
      A6JZI8
      Conserved Domains (8) summary
      smart00219
      Location:836 → 1104
      TyrKc; Tyrosine kinase, catalytic domain
      smart00410
      Location:370 → 444
      IG_like; Immunoglobulin like
      cd00054
      Location:315 → 346
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00055
      Location:228 → 266
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00063
      Location:643 → 735
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05089
      Location:833 → 1129
      PTKc_Tie1; Catalytic domain of the Protein Tyrosine Kinase, Tie1
      pfam00041
      Location:549 → 631
      fn3; Fibronectin type III domain
      pfam00047
      Location:130 → 211
      ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version

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