Dnah17 dynein, axonemal, heavy chain 17 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dnah17provided by RGD
Official Full Name: dynein, axonemal, heavy chain 17provided by RGD
Primary source: RGD:1563805
See related: Ensembl:ENSRNOG00000003028 AllianceGenome:RGD:1563805
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dnahc11; Dnahc17
Summary: Predicted to enable several functions, including ATP binding activity; dynein intermediate chain binding activity; and dynein light intermediate chain binding activity. Predicted to be involved in outer dynein arm assembly. Predicted to be located in axoneme and sperm flagellum. Predicted to be part of outer dynein arm. Human ortholog(s) of this gene implicated in spermatogenic failure 39. Orthologous to human DNAH17 (dynein axonemal heavy chain 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 115.3), Adrenal (RPKM 7.1) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.2

Exon count:: 80

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (103748033..103862009, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (103244144..103364953, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (107028115..107161288, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DNAH17 is essential for rat spermatogenesis and fertility.
Title: DNAH17 is essential for rat spermatogenesis and fertility.
results suggested that the possibility of stress-induced depressive behavior associated with hippocampal neurodegeneration process is correlated with a low expression of kinesin and dynein, the two most important proteins in axonal transport.
Title: Axonal transport proteins and depressive like behavior, following Chronic Unpredictable Mild Stress in male rat.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH134362 (e-PCR)
- UniSTS:217644

RH133135 (e-PCR)
- UniSTS:216418

d10rat5 (e-PCR)
- UniSTS:120713

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in outer dynein arm assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axoneme	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
part_of outer dynein arm	ISO Inferred from Sequence Orthology more info
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dynein heavy chain 17, axonemal; dynein axonemal heavy chain 17

Names: beta heavy chain of outer-arm axonemal dynein ATPase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

103748033..103862009 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039087512.2 → XP_038943440.1 dynein axonemal heavy chain 17

UniProtKB/TrEMBL

D4A599

Conserved Domains (6) summary

COG5245
Location:1493 → 4124

DYN1; Dynein, heavy chain [Cytoskeleton]

pfam12777
Location:3040 → 3383

MT; Microtubule-binding stalk of dynein motor

pfam08385
Location:187 → 764

DHC_N1; Dynein heavy chain, N-terminal region 1

pfam08393
Location:1266 → 1672

DHC_N2; Dynein heavy chain, N-terminal region 2

pfam12774
Location:1806 → 2132

AAA_6; Hydrolytic ATP binding site of dynein motor region D1

pfam18199
Location:4162 → 4457

Dynein_C; Dynein heavy chain C-terminal domain