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    Afmid arylformamidase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 688283, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Afmidprovided by RGD
    Official Full Name
    arylformamidaseprovided by RGD
    Primary source
    RGD:1591143
    See related
    Ensembl:ENSRNOG00000050205 AllianceGenome:RGD:1591143
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable hydrolase activity. Predicted to be involved in tryptophan catabolic process to kynurenine. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Orthologous to human AFMID (arylformamidase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 253.1), Kidney (RPKM 192.1) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    10q32.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (103544822..103560408)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (103046129..103061718)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (106828963..106844314)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene synaptogyrin 2 Neighboring gene thymidine kinase 1 Neighboring gene uncharacterized LOC102548046 Neighboring gene baculoviral IAP repeat-containing 5 Neighboring gene transmembrane protein 235

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Alternate activation of two divergently transcribed mouse genes from a bidirectional promoter is linked to changes in histone modification. Schuettengruber B, et al. J Biol Chem, 2003 Jan 17. PMID 12411446
    2. Effect of arylformamidase (kynurenine formamidase) gene inactivation in mice on enzymatic activity, kynurenine pathway metabolites and phenotype. Dobrovolsky VN, et al. Biochim Biophys Acta, 2005 Jun 20. PMID 15866519
    3. The kynurenine pathway and neurodegenerative disease. Maddison DC, et al. Semin Cell Dev Biol, 2015 Apr. PMID 25773161
    4. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables arylformamidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' NAD biosynthetic process from tryptophan IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tryptophan catabolic process to kynurenine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tryptophan catabolic process to kynurenine IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tryptophan catabolic process to kynurenine ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kynurenine formamidase
    NP_001104836.1
    XP_006247885.1
    XP_017453019.1
    XP_063125935.1
    XP_063125936.1
    XP_063125937.1
    XP_063125938.1
    XP_063125940.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111366.1 → NP_001104836.1  kynurenine formamidase

      See identical proteins and their annotated locations for NP_001104836.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A0A8I6GH15, A6HL34, M0RC77
      Related
      ENSRNOP00000067187.1, ENSRNOT00000073809.2
      Conserved Domains (2) summary
      COG0657
      Location:56 → 298
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      cl21494
      Location:90 → 280
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      103544822..103560408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597530.3 → XP_017453019.1  kynurenine formamidase isoform X2

      UniProtKB/TrEMBL
      A0A8I6GH15

    2. XM_006247823.5 → XP_006247885.1  kynurenine formamidase isoform X3

      UniProtKB/TrEMBL
      A0A8I6GH15
      Conserved Domains (2) summary
      COG0657
      Location:56 → 261
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      cl21494
      Location:90 → 261
      Abhydrolase; alpha/beta hydrolases

    3. XM_063269865.1 → XP_063125935.1  kynurenine formamidase isoform X1

    4. XM_063269867.1 → XP_063125937.1  kynurenine formamidase isoform X4

    5. XM_063269868.1 → XP_063125938.1  kynurenine formamidase isoform X5

    6. XM_063269870.1 → XP_063125940.1  kynurenine formamidase isoform X6

    7. XM_063269866.1 → XP_063125936.1  kynurenine formamidase isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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