Trpv2 transient receptor potential cation channel, subfamily V, member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trpv2provided by RGD
Official Full Name: transient receptor potential cation channel, subfamily V, member 2provided by RGD
Primary source: RGD:3965
See related: Ensembl:ENSRNOG00000003104 AllianceGenome:RGD:3965
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Vrl1
Summary: Enables identical protein binding activity. Involved in negative regulation of cell population proliferation and response to heat. Located in several cellular components, including endomembrane system; lamellipodium; and plasma membrane. Orthologous to human TRPV2 (transient receptor potential cation channel subfamily V member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 104.8), Lung (RPKM 91.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q23

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (47772223..47797956)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (47265524..47294263)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (48903540..48925036)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of TRPV2 as a regulator on the osteoclast differentiation during orthodontic tooth movement in rats.
Title: The role of TRPV2 as a regulator on the osteoclast differentiation during orthodontic tooth movement in rats.
Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function.
Title: Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function.
Loss of TRPV2-mediated blood flow autoregulation recapitulates diabetic retinopathy in rats.
Title: Loss of TRPV2-mediated blood flow autoregulation recapitulates diabetic retinopathy in rats.
Tyrosine phosphorylation tunes chemical and thermal sensitivity of TRPV2 ion channel.
Title: Tyrosine phosphorylation tunes chemical and thermal sensitivity of TRPV2 ion channel.
Oxidative Stress-Induced TRPV2 Expression Increase Is Involved in Diabetic Cataracts and Apoptosis of Lens Epithelial Cells in a High-Glucose Environment.
Title: Oxidative Stress-Induced TRPV2 Expression Increase Is Involved in Diabetic Cataracts and Apoptosis of Lens Epithelial Cells in a High-Glucose Environment.
Identification of a helix-turn-helix motif for high temperature dependence of vanilloid receptor TRPV2.
Title: Identification of a helix-turn-helix motif for high temperature dependence of vanilloid receptor TRPV2.
Tetrandrine Ameliorates Myocardial Ischemia Reperfusion Injury through miR-202-5p/TRPV2.
Title: Tetrandrine Ameliorates Myocardial Ischemia Reperfusion Injury through miR-202-5p/TRPV2.
miR-202-5p protects rat against myocardial ischemia reperfusion injury by downregulating the expression of Trpv2 to attenuate the Ca (2+) overload in cardiomyocytes.
Title: miR-202-5p protects rat against myocardial ischemia reperfusion injury by downregulating the expression of Trpv2 to attenuate the Ca (2+) overload in cardiomyocytes.
the selectivity filters in TRPV1-3 channels do not function as activation gates
Title: The ion selectivity filter is not an activation gate in TRPV1-3 channels.
A methionine-dependent redox sensitivity of TRPV2 which may be an important endogenous mechanism for regulation of TRPV2 activity and account for its pivotal role for phagocytosis in macrophages.
Title: Oxidation of methionine residues activates the high-threshold heat-sensitive ion channel TRPV2.

Submit: New GeneRIF Correction See all GeneRIFs (47)

General gene information

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Markers

Trpv2 (e-PCR), detects polymorphism
- UniSTS:531255

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables calcium channel activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
NOT involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in calcium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon extension	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of axon extension	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion import	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in response to temperature stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to temperature stimulus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axonal growth cone	IEA Inferred from Electronic Annotation more info
located_in axonal growth cone	ISO Inferred from Sequence Orthology more info
located_in cell body	IEA Inferred from Electronic Annotation more info
located_in cell body	ISO Inferred from Sequence Orthology more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in endomembrane system	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone membrane	IEA Inferred from Electronic Annotation more info
located_in growth cone membrane	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in melanosome	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transient receptor potential cation channel subfamily V member 2

Names: OTRPC2; VRL-1; osm-9-like TRP channel 2; stretch-activated channel 2B; vanilloid receptor-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001270797.1 → NP_001257726.1 transient receptor potential cation channel subfamily V member 2

See identical proteins and their annotated locations for NP_001257726.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.

Source sequence(s)

BC089215, JAXUCZ010000010

UniProtKB/Swiss-Prot

Q5FWT3, Q9JMI8, Q9QYH8, Q9WUD2

UniProtKB/TrEMBL

A0A0G2JSH6

Conserved Domains (2) summary

sd00045
Location:164 → 194

ANK; ANK repeat [structural motif]

cd22197
Location:71 → 710

TRPV2; Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2
NM_001270798.1 → NP_001257727.1 transient receptor potential cation channel subfamily V member 2

See identical proteins and their annotated locations for NP_001257727.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.

Source sequence(s)

BC089215, JAXUCZ010000010

UniProtKB/Swiss-Prot

Q5FWT3, Q9JMI8, Q9QYH8, Q9WUD2

UniProtKB/TrEMBL

A0A0G2JSH6

Conserved Domains (2) summary

sd00045
Location:164 → 194

ANK; ANK repeat [structural motif]

cd22197
Location:71 → 710

TRPV2; Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2
NM_017207.3 → NP_058903.2 transient receptor potential cation channel subfamily V member 2

See identical proteins and their annotated locations for NP_058903.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.

Source sequence(s)

BC089215, JAXUCZ010000010

UniProtKB/Swiss-Prot

Q5FWT3, Q9JMI8, Q9QYH8, Q9WUD2

UniProtKB/TrEMBL

A0A0G2JSH6

Related

ENSRNOP00000004248.4, ENSRNOT00000004248.7

Conserved Domains (2) summary

sd00045
Location:164 → 194

ANK; ANK repeat [structural motif]

cd22197
Location:71 → 710

TRPV2; Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

47772223..47797956

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063268817.1 → XP_063124887.1 transient receptor potential cation channel subfamily V member 2 isoform X1

UniProtKB/TrEMBL

A0A0G2JSH6
XM_063268816.1 → XP_063124886.1 transient receptor potential cation channel subfamily V member 2 isoform X1

UniProtKB/TrEMBL

A0A0G2JSH6
XM_063268815.1 → XP_063124885.1 transient receptor potential cation channel subfamily V member 2 isoform X1

UniProtKB/TrEMBL

A0A0G2JSH6