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    Rasgrp2 RAS guanyl releasing protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361714, updated on 2-May-2024

    Summary

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    Official Symbol
    Rasgrp2provided by RGD
    Official Full Name
    RAS guanyl releasing protein 2provided by RGD
    Primary source
    RGD:1311630
    See related
    Ensembl:ENSRNOG00000021098 AllianceGenome:RGD:1311630
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in cellular response to calcium ion and positive regulation of GTPase activity. Predicted to be located in cytosol and plasma membrane. Human ortholog(s) of this gene implicated in platelet-type bleeding disorder 18. Orthologous to human RASGRP2 (RAS guanyl releasing protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 149.7), Thymus (RPKM 118.2) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rasgrp2 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (213135034..213152246)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (203705777..203722993)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (221771238..221788765)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483960 Neighboring gene U7 small nuclear RNA Neighboring gene splicing factor 1 Neighboring gene uncharacterized LOC120097407 Neighboring gene glycogen phosphorylase, muscle associated Neighboring gene neurexin 2 Neighboring gene solute carrier family 22 member 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleeding. Canault M, et al. J Exp Med, 2014 Jun 30. PMID 24958846, Free PMC Article
    2. Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor. Clyde-Smith J, et al. J Biol Chem, 2000 Oct 13. PMID 10918068
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to calcium ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RAS guanyl-releasing protein 2
    Names
    RAS guanyl releasing protein 2 (calcium and DAG-regulated)
    calDAG-GEFI
    calcium and DAG-regulated guanine nucleotide exchange factor I

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082977.2 → NP_001076446.2  RAS guanyl-releasing protein 2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P0C643
      UniProtKB/TrEMBL
      A6HZH1
      Related
      ENSRNOP00000028646.7, ENSRNOT00000028646.7
      Conserved Domains (4) summary
      smart00147
      Location:150 → 387
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:7 → 121
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00051
      Location:430 → 481
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd20861
      Location:496 → 551
      C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      213135034..213152246
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230854.5 → XP_006230916.1  RAS guanyl-releasing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006230916.1

      UniProtKB/Swiss-Prot
      P0C643
      UniProtKB/TrEMBL
      A6HZH1
      Conserved Domains (4) summary
      smart00147
      Location:150 → 387
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:7 → 121
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00051
      Location:430 → 481
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd20861
      Location:496 → 551
      C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

    2. XM_063268258.1 → XP_063124328.1  RAS guanyl-releasing protein 2 isoform X1

      UniProtKB/TrEMBL
      A6HZH1

    3. XM_063268277.1 → XP_063124347.1  RAS guanyl-releasing protein 2 isoform X1

      UniProtKB/TrEMBL
      A6HZH1

    4. XM_063268267.1 → XP_063124337.1  RAS guanyl-releasing protein 2 isoform X1

      UniProtKB/TrEMBL
      A6HZH1

    5. XM_063268269.1 → XP_063124339.1  RAS guanyl-releasing protein 2 isoform X1

      UniProtKB/TrEMBL
      A6HZH1

    6. XM_039083977.2 → XP_038939905.1  RAS guanyl-releasing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      P0C643
      UniProtKB/TrEMBL
      A6HZH1
      Conserved Domains (4) summary
      smart00147
      Location:150 → 387
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:7 → 121
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00051
      Location:430 → 481
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd20861
      Location:496 → 551
      C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

    7. XM_006230853.3 → XP_006230915.1  RAS guanyl-releasing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006230915.1

      UniProtKB/Swiss-Prot
      P0C643
      UniProtKB/TrEMBL
      A6HZH1
      Conserved Domains (4) summary
      smart00147
      Location:150 → 387
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:7 → 121
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00051
      Location:430 → 481
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd20861
      Location:496 → 551
      C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

    8. XM_039084004.1 → XP_038939932.1  RAS guanyl-releasing protein 2 isoform X3

      UniProtKB/TrEMBL
      A6HZH4
      Conserved Domains (1) summary
      smart00229
      Location:7 → 121
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

    9. XM_006230857.3 → XP_006230919.1  RAS guanyl-releasing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006230919.1

      UniProtKB/Swiss-Prot
      P0C643
      UniProtKB/TrEMBL
      A6HZH1
      Conserved Domains (4) summary
      smart00147
      Location:150 → 387
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:7 → 121
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00051
      Location:430 → 481
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd20861
      Location:496 → 551
      C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

    10. XM_063268263.1 → XP_063124333.1  RAS guanyl-releasing protein 2 isoform X1

      UniProtKB/TrEMBL
      A6HZH1

    11. XM_063268278.1 → XP_063124348.1  RAS guanyl-releasing protein 2 isoform X1

      UniProtKB/TrEMBL
      A6HZH1

    12. XM_006230855.5 → XP_006230917.1  RAS guanyl-releasing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006230917.1

      UniProtKB/Swiss-Prot
      P0C643
      UniProtKB/TrEMBL
      A6HZH1
      Conserved Domains (4) summary
      smart00147
      Location:150 → 387
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:7 → 121
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00051
      Location:430 → 481
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd20861
      Location:496 → 551
      C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins

    13. XM_063268264.1 → XP_063124334.1  RAS guanyl-releasing protein 2 isoform X1

      UniProtKB/TrEMBL
      A6HZH1

    14. XM_063268283.1 → XP_063124353.1  RAS guanyl-releasing protein 2 isoform X1

      UniProtKB/TrEMBL
      A6HZH1

    15. XM_039083991.2 → XP_038939919.1  RAS guanyl-releasing protein 2 isoform X2

      Conserved Domains (3) summary
      smart00147
      Location:5 → 242
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00051
      Location:285 → 336
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cd20861
      Location:351 → 406
      C1_RASGRP2; protein kinase C conserved region 1 (C1 domain) found in RAS guanyl-releasing protein 2 (RASGRP2) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C643.1 GenPept UniProtKB/Swiss-Prot:P0C643

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