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    INAFM2 InaF motif containing 2 [ Homo sapiens (human) ]

    Gene ID: 100505573, updated on 8-Mar-2024

    Summary

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    Official Symbol
    INAFM2provided by HGNC
    Official Full Name
    InaF motif containing 2provided by HGNC
    Primary source
    HGNC:HGNC:35165
    See related
    Ensembl:ENSG00000259330 AllianceGenome:HGNC:35165
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OGU1; LINC00984
    Summary
    Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thyroid (RPKM 12.3), brain (RPKM 7.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    15q15.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (40323692..40326715)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (38130541..38133587)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (40615893..40618916)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40583508-40584053 Neighboring gene phospholipase C beta 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40584054-40584598 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9239 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:40594309-40595118 Neighboring gene uncharacterized LOC112268152 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:40602266-40602469 Neighboring gene ribosomal protein lateral stalk subunit P0 pseudogene 10 Neighboring gene NANOG hESC enhancer GRCh37_chr15:40613053-40613570 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6323 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6324 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6325 Neighboring gene Sharpr-MPRA regulatory region 6286 Neighboring gene RNA, 5S ribosomal pseudogene 392 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40628805-40629323 Neighboring gene coiled-coil domain containing 9B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40632233-40633036 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40635981-40636480 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40636664-40637261 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40637262-40637858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:40646605-40647130 Neighboring gene proline, histidine and glycine rich 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Interactive associations of the INAFM2 rs67839313 variant and egg consumption with type 2 diabetes mellitus and fasting blood glucose in a Chinese population: A family-based study. Wang X, et al. Gene, 2021 Feb 20. PMID 33333222
    2. Transcripts of unknown function in multiple-signaling pathways involved in human stem cell differentiation. Kikuchi K, et al. Nucleic Acids Res, 2009 Aug. PMID 19531736, Free PMC Article
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interactive associations of the INAFM2 rs67839313 variant and egg consumption with type 2 diabetes mellitus and fasting blood glucose in a Chinese population: A family-based study.
      Title: Interactive associations of the INAFM2 rs67839313 variant and egg consumption with type 2 diabetes mellitus and fasting blood glucose in a Chinese population: A family-based study.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ41776, DKFZp762E1314

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative transmembrane protein INAFM2
    Names
    inaF-motif-containing protein 2
    osteogenesis up-regulated transcript 1
    osteogenesis upregulating transcript 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301268.2 → NP_001288197.1  putative transmembrane protein INAFM2

      See identical proteins and their annotated locations for NP_001288197.1

      Status: VALIDATED

      Source sequence(s)
      AC013356, AK123770, AL832909, BC036424, BE250750
      Consensus CDS
      CCDS86448.1
      UniProtKB/Swiss-Prot
      P0DMQ5
      Related
      ENSP00000492634.1, ENST00000638170.2
      Conserved Domains (1) summary
      pfam15018
      Location:31 → 63
      InaF-motif; TRP-interacting helix

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      40323692..40326715
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011521149.4 → XP_011519451.1  putative transmembrane protein INAFM2 isoform X1

      See identical proteins and their annotated locations for XP_011519451.1

      UniProtKB/Swiss-Prot
      P0DMQ5
      Conserved Domains (1) summary
      pfam15018
      Location:31 → 63
      InaF-motif; TRP-interacting helix

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      38130541..38133587
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377169.1 → XP_054233144.1  putative transmembrane protein INAFM2 isoform X1

      UniProtKB/Swiss-Prot
      P0DMQ5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0DMQ5.1 GenPept UniProtKB/Swiss-Prot:P0DMQ5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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