Crym crystallin, mu [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Crymprovided by RGD
Official Full Name: crystallin, muprovided by RGD
Primary source: RGD:620943
See related: Ensembl:ENSRNOG00000061215 AllianceGenome:RGD:620943
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CDK108
Summary: Predicted to enable several functions, including protein homodimerization activity; thiomorpholine-carboxylate dehydrogenase activity; and thyroid hormone binding activity. Involved in mitochondrial transport; response to hormone; and response to vitamin D. Located in cytosol. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 40. Orthologous to human CRYM (crystallin mu). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 911.0), Brain (RPKM 435.1) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q36

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (183991752..184006923, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (174560423..174575660, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (189944895..189960069, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results suggest that mu-crystallin may play roles in development of cortical and hippocampal pyramidal cells in the early postnatal period, and in the later period, performs cell-specific functions in selected neuronal populations.
Title: Expression of CRYM in different rat organs during development and its decreased expression in degenerating pyramidal tracts in amyotrophic lateral sclerosis.
CRYM expression increases and sustains the T3 responsiveness of genes in cells, especially with alteration of the pericellular T3 concentration.
Title: Cytosolic T3-binding protein modulates dynamic alteration of T3-mediated gene expression in cells.
This is the first report linking hyperglycemia with thyroid hormone binding protein CRYM and suggests that the role of CRYM in diabetic complications should be further investigated.
Title: Hyperglycemia induces elevated expression of thyroid hormone binding protein in vivo in kidney and heart and in vitro in mesangial cells.
Crym protein was predominantly distributed in the fibrocytes in the spiral ligament, as well as the stria vascularis of cochlea in rats.
Title: The localization of proteins encoded by CRYM, KIAA1199, UBA52, COL9A3, and COL9A1, genes highly expressed in the cochlea.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NADP binding	ISO Inferred from Sequence Orthology more info
enables hormone binding	IEA Inferred from Electronic Annotation more info
enables hormone binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables thiomorpholine-carboxylate dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables thiomorpholine-carboxylate dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables thyroid hormone binding	IBA Inferred from Biological aspect of Ancestor more info
enables thyroid hormone binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in mitochondrial transport	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin D	IEP Inferred from Expression Pattern more info	PubMed
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in thyroid hormone metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in thyroid hormone metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within thyroid hormone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in thyroid hormone transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ketimine reductase mu-crystallin

Names: NADP-regulated thyroid-hormone-binding protein; mu-crystallin homolog; thiomorpholine-carboxylate dehydrogenase

NP_446407.1

EC 1.5.1.25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053955.2 → NP_446407.1 ketimine reductase mu-crystallin

See identical proteins and their annotated locations for NP_446407.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q9QYU4

UniProtKB/TrEMBL

A0A0G2K568, A6I8Q4

Related

ENSRNOP00000073313.2, ENSRNOT00000088482.2

Conserved Domains (2) summary

pfam02423
Location:5 → 312

OCD_Mu_crystall; Ornithine cyclodeaminase/mu-crystallin family

cl21454
Location:40 → 307

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins