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    PLAC9 placenta associated 9 [ Homo sapiens (human) ]

    Gene ID: 219348, updated on 5-Mar-2024

    Summary

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    Official Symbol
    PLAC9provided by HGNC
    Official Full Name
    placenta associated 9provided by HGNC
    Primary source
    HGNC:HGNC:19255
    See related
    Ensembl:ENSG00000189129 MIM:612857; AllianceGenome:HGNC:19255
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in fat (RPKM 55.2), prostate (RPKM 10.1) and 10 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PLAC9 in Genome Data Viewer
    Location:
    10q22.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (80131661..80145359)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (81000769..81014482)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (81891417..81905115)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene TMEM254 antisense RNA 1 Neighboring gene transmembrane protein 254 Neighboring gene ribosomal protein L22 pseudogene 18 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:81917938-81919137 Neighboring gene annexin A11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81928334-81928862 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2543 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:81931132-81932057 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81936179-81936680 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81936681-81937180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81937700-81938200 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:81945900-81946400 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3649 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81954116-81954792 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:81954793-81955468 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:81955517-81956716 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3650 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3651 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2544 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:81966703-81967902 Neighboring gene long intergenic non-protein coding RNA 857 Neighboring gene ribosomal protein S12 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Placenta-specific 9, a putative secretory protein, induces G2/M arrest and inhibits the proliferation of human embryonic hepatic cells. Ouyang C, et al. Biosci Rep, 2018 Dec 21. PMID 30291214, Free PMC Article
    2. Plac8 and Plac9, novel placental-enriched genes identified through microarray analysis. Galaviz-Hernandez C, et al. Gene, 2003 May 8. PMID 12758124
    3. The DNA sequence and comparative analysis of human chromosome 10. Deloukas P, et al. Nature, 2004 May 27. PMID 15164054
    4. Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins. Yang J, et al. Cell Rep, 2023 Feb 28. PMID 36724073
    5. Toward an understanding of the protein interaction network of the human liver. Wang J, et al. Mol Syst Biol, 2011 Oct 11. PMID 21988832, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC104710

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    placenta-specific protein 9
    Names
    placenta specific 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012973.3 → NP_001012991.1  placenta-specific protein 9 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001012991.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL356095
      Consensus CDS
      CCDS31232.1
      UniProtKB/Swiss-Prot
      Q5JTB6
      Related
      ENSP00000361337.3, ENST00000372263.4
      Conserved Domains (1) summary
      pfam15205
      Location:23 → 96
      PLAC9; Placenta-specific protein 9

    2. NM_001331125.2 → NP_001318054.1  placenta-specific protein 9 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AA460691, AL356095, BC066348, BU731023
      Consensus CDS
      CCDS86126.1
      UniProtKB/TrEMBL
      Q5JTB5
      Related
      ENSP00000361341.2, ENST00000372267.6

    RNA

    1. NR_138551.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' end compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AL356095, BU731023, EL950785

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      80131661..80145359
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      81000769..81014482
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364994.1 → XP_054220969.1  placenta-specific protein 9 isoform X1

      UniProtKB/Swiss-Prot
      Q5JTB6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5JTB6.1 GenPept UniProtKB/Swiss-Prot:Q5JTB6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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