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    Scamp3 secretory carrier membrane protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 24045, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Scamp3provided by MGI
    Official Full Name
    secretory carrier membrane protein 3provided by MGI
    Primary source
    MGI:MGI:1346346
    See related
    Ensembl:ENSMUSG00000028049 AllianceGenome:MGI:1346346
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sc3
    Summary
    Predicted to enable ubiquitin protein ligase binding activity. Acts upstream of or within response to retinoic acid. Located in Golgi membrane. Orthologous to human SCAMP3 (secretory carrier membrane protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 100.4), thymus adult (RPKM 60.9) and 28 other tissues See more
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    Genomic context

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    Location:
    3 F1; 3 39.01 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89084698..89090077)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89177391..89182770)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene pyruvate kinase liver and red blood cell Neighboring gene hyperpolarization-activated, cyclic nucleotide-gated K+ 3 Neighboring gene predicted gene, 45927 Neighboring gene CDC-like kinase 2 Neighboring gene STARR-positive B cell enhancer ABC_E2079 Neighboring gene predicted gene 16069 Neighboring gene endosomal transmembrane epsin interactor 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:88994426-88994609 Neighboring gene STARR-positive B cell enhancer ABC_E275 Neighboring gene STARR-positive B cell enhancer ABC_E10196 Neighboring gene predicted gene, 23269 Neighboring gene glucosylceramidase beta 1 Neighboring gene metaxin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Gene identification signature (GIS) analysis for transcriptome characterization and genome annotation. Ng P, et al. Nat Methods, 2005 Feb. PMID 15782207
    2. Three mammalian SCAMPs (secretory carrier membrane proteins) are highly related products of distinct genes having similar subcellular distributions. Singleton DR, et al. J Cell Sci, 1997 Sep. PMID 9378760
    3. Novel SCAMPs lacking NPF repeats: ubiquitous and synaptic vesicle-specific forms implicate SCAMPs in multiple membrane-trafficking functions. Fernández-Chacón R, et al. J Neurosci, 2000 Nov 1. PMID 11050114, Free PMC Article
    4. Detailed characterization of the mouse embryonic stem cell transcriptome reveals novel genes and intergenic splicing associated with pluripotency. Kunarso G, et al. BMC Genomics, 2008 Apr 9. PMID 18400104, Free PMC Article
    5. Munc18-1 stabilizes syntaxin 1, but is not essential for syntaxin 1 targeting and SNARE complex formation. Toonen RF, et al. J Neurochem, 2005 Jun. PMID 15935055

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough Gm45927

    Readthrough gene: Gm45927, Included gene: Clk2

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular protein transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to organic substance IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to retinoic acid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in recycling endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in trans-Golgi network membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    secretory carrier-associated membrane protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001309909.1 → NP_001296838.1  secretory carrier-associated membrane protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001296838.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AA939832, AC161600, AK135335, AK160549, AV092991
      Consensus CDS
      CCDS84640.1
      UniProtKB/TrEMBL
      Q3UK26, Q3UXS0
      Related
      ENSMUSP00000112846.2, ENSMUST00000120697.8
      Conserved Domains (1) summary
      pfam04144
      Location:135 → 310
      SCAMP; SCAMP family

    2. NM_001309910.1 → NP_001296839.1  secretory carrier-associated membrane protein 3 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region and lacks an in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AA939832, AC161600, AK160549, AV092991
      Consensus CDS
      CCDS84641.1
      UniProtKB/TrEMBL
      E9Q855, Q3TDM8
      Related
      ENSMUSP00000096540.5, ENSMUST00000098941.5
      Conserved Domains (1) summary
      pfam04144
      Location:134 → 275
      SCAMP; SCAMP family

    3. NM_011886.3 → NP_036016.2  secretory carrier-associated membrane protein 3 isoform 2

      See identical proteins and their annotated locations for NP_036016.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AA939832, AC161600, AK160549, AV092991
      Consensus CDS
      CCDS50959.1
      UniProtKB/Swiss-Prot
      O35609, Q3TUV6, Q99M48, Q9ERM9
      UniProtKB/TrEMBL
      Q3UK26
      Related
      ENSMUSP00000029684.9, ENSMUST00000029684.15
      Conserved Domains (1) summary
      pfam04144
      Location:134 → 309
      SCAMP; SCAMP family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      89084698..89090077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35609.3 GenPept UniProtKB/Swiss-Prot:O35609

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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