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    Tll2 tolloid-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 24087, updated on 12-May-2024

    Summary

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    Official Symbol
    Tll2provided by MGI
    Official Full Name
    tolloid-like 2provided by MGI
    Primary source
    MGI:MGI:1346044
    See related
    Ensembl:ENSMUSG00000025013 AllianceGenome:MGI:1346044
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable calcium ion binding activity; metalloendopeptidase activity; and zinc ion binding activity. Acts upstream of or within negative regulation of skeletal muscle tissue growth. Predicted to be located in extracellular region. Is expressed in diencephalon floor plate; diencephalon lateral wall ventricular layer; and pituitary gland. Orthologous to human TLL2 (tolloid like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 C3; 19 34.39 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (41069379..41199287, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (41080940..41210848, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:41103805-41103914 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:41105621-41105774 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:41113653-41113854 Neighboring gene STARR-seq mESC enhancer starr_46143 Neighboring gene deoxynucleotidyltransferase, terminal Neighboring gene STARR-positive B cell enhancer mm9_chr19:41146037-41146338 Neighboring gene STARR-seq mESC enhancer starr_46144 Neighboring gene oligodendrocytic myelin paranodal and inner loop protein Neighboring gene STARR-seq mESC enhancer starr_46145 Neighboring gene transmembrane 9 superfamily member 3 Neighboring gene STARR-positive B cell enhancer ABC_E11676 Neighboring gene predicted gene, 54045 Neighboring gene phosphoinositide-3-kinase adaptor protein 1 Neighboring gene predicted gene, 52406

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures. Uzel MI, et al. J Biol Chem, 2001 Jun 22. PMID 11313359
    2. Mammalian tolloid proteinases: role in growth factor signalling. Troilo H, et al. FEBS Lett, 2016 Aug. PMID 27391803, Free PMC Article
    3. Genetic analysis of the role of proteolysis in the activation of latent myostatin. Lee SJ. PLoS One, 2008 Feb 20. PMID 18286185, Free PMC Article
    4. An oligodendrocyte enhancer in a phylogenetically conserved intron region of the mammalian myelin gene Opalin. Aruga J, et al. J Neurochem, 2007 Sep. PMID 17442045
    5. Assignment of TLL1 and TLL2, which encode human BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32-->q33 and 10q23-->q24 and assignment of murine Tll2 to chromosome 19. Scott IC, et al. Cytogenet Cell Genet, 1999. PMID 10516436

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. loss-of-function mutation in Tll2, has a small, but significant, effect on muscle mass
      Title: Genetic analysis of the role of proteolysis in the activation of latent myostatin.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dorsal/ventral pattern formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of skeletal muscle tissue growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tolloid-like protein 2
    NP_036034.1
    XP_006527155.1
    XP_006527158.1
    XP_017173690.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011904.4 → NP_036034.1  tolloid-like protein 2 precursor

      See identical proteins and their annotated locations for NP_036034.1

      Status: VALIDATED

      Source sequence(s)
      AC121873, AC133099
      Consensus CDS
      CCDS37986.1
      UniProtKB/Swiss-Prot
      A2RTK3, Q9WVM6
      UniProtKB/TrEMBL
      E9Q5B9
      Related
      ENSMUSP00000025986.8, ENSMUST00000025986.15
      Conserved Domains (4) summary
      cd04281
      Location:147 → 346
      ZnMc_BMP1_TLD; Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural proteins, ...
      pfam00431
      Location:461 → 570
      CUB; CUB domain
      pfam01400
      Location:154 → 347
      Astacin; Astacin (Peptidase family M12A)
      pfam14670
      Location:733 → 768
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      41069379..41199287 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527092.5 → XP_006527155.1  tolloid-like protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006527155.1

      UniProtKB/TrEMBL
      B7ZNA8, E9Q5B9
      Conserved Domains (3) summary
      cd04281
      Location:26 → 201
      ZnMc_BMP1_TLD; Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural proteins, ...
      pfam00431
      Location:316 → 425
      CUB; CUB domain
      pfam14670
      Location:588 → 623
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    2. XM_017318201.1 → XP_017173690.1  tolloid-like protein 2 isoform X3

      Conserved Domains (2) summary
      pfam00431
      Location:122 → 231
      CUB; CUB domain
      pfam14670
      Location:394 → 429
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    3. XM_006527095.3 → XP_006527158.1  tolloid-like protein 2 isoform X2

      Conserved Domains (3) summary
      cd04281
      Location:147 → 346
      ZnMc_BMP1_TLD; Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural proteins, ...
      pfam00431
      Location:461 → 570
      CUB; CUB domain
      pfam14670
      Location:581 → 613
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WVM6.1 GenPept UniProtKB/Swiss-Prot:Q9WVM6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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